Anti-actin antibodies

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schematic representation of antibody.

Anti-actin antibodies. Anti-actin antibodies are found at increased frequency in certain autoimmune diseases and may be of some diagnostic value.

In coeliac disease anti-actin antibodies correlated with the level of intestinal damage. [1][2]

In autoimmune hepatitis anti-actin antibodies correlate with patterns of immune recognition[3], the pattern of recognition was specific to a small percentage of auto-immune hepatitis type 1 or cryptogenic hepatitis patients.[4]

in gastric cancer anti-actin antibodies were elevated, along with other antibodies in severe disease with poor outcomes.[5]


  1. Pedreira S, Sugai E, Moreno ML; et al. (2005). "Significance of smooth muscle/anti-actin autoantibodies in celiac disease". Acta Gastroenterol. Latinoam. 35 (2): 83–93. PMID 16127984.
  2. Carroccio A, Brusca I, Iacono G; et al. (2007). "IgA anti-actin antibodies ELISA in coeliac disease: A multicentre study". doi:10.1016/j.dld.2007.06.004. PMID 17652043.
  3. Muratori P, Muratori L, Agostinelli D; et al. (2002). "Smooth muscle antibodies and type 1 autoimmune hepatitis". Autoimmunity. 35 (8): 497–500. PMID 12765475.
  4. Ballot E, Homberg JC, Johanet C (2000). "Antibodies to soluble liver antigen: an additional marker in type 1 auto-immune hepatitis". J. Hepatol. 33 (2): 208–15. PMID 10952238.
  5. Konstandoulakis MM, Syrigos KN, Leandros M, Charalabopoulos A, Manouras A, Golematis BC (1998). "Autoantibodies in the serum of patients with gastric cancer: their prognostic importance". Hybridoma. 17 (5): 431–5. PMID 9873988.