Anti-LKM antibody

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Anti-Liver Kidney Microsomal Antibodies (Anti-LKM antibody) are detected in serum of patients with different types of acute or chronic liver disease. These antibodies are targeted against cytochrome-P450 antigens. Three kind of Anti LKM is studied extensively-

Microsomal Antibodies	Antigen	Disease
Anti-LKM 1	Cytochrome P450 2D6	Autoimmune Hepatitis type II and Chronic Hepatitis C(10%)
Anti-LKM 2	Cytochrome P450 2C9	Drug Induced Hepatitis(Tienilic acid induced)
Anti-LKM 3	Cytochrome P450 1A2	Chronic Hepatitis D