Angiopoietin Receptors: Tie-1 & Tie-2

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tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Identifiers
SymbolTIE1
Alt. symbolsTIE, JTK14
Entrez7075
HUGO11809
OMIM600222
RefSeqNM_005424
UniProtP35590
Other data
EC number2.7.1.112
LocusChr. 1 p34-p33
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)
Identifiers
SymbolTEK
Alt. symbolsVMCM, TIE2, TIE-2, VMCM1, CD202b
Entrez7010
HUGO11724
OMIM600221
RefSeqNM_000459
UniProtQ02763
Other data
LocusChr. 9 p21

Tie-1 and Tie-2 comprise the cell-surface receptors which bind and are activated by the angiopoietins, (Ang1, Ang2, Ang3, Ang4). The angiopoietins are protein growth factors required for the formation of blood vessels (angiogenesis).

Angiopoietins

The angiopoietins are protein growth factors that promote angiogenesis, the formation of blood vessels. There are now four identified angiopoietins: Ang1, Ang2, Ang3, Ang4. They function by binding their physiologic receptors, Tie-1 and Tie-2. These are receptor tyrosine kinases, so named because they mediate cell signals by inducing the phosphorylation of key tyrosines, thus initiating cell signalling. It is somewhat controversial which of the Tie receptors mediate functional signals downstream of Ang stimulation - but it is clear that at least Tie-2 is capable of physiologic activation as a result of binding the angiopoietins

Tie Receptor Signaling

External links


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