Anaphylaxis epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Epidemiology and Demographics

Developed Countries

An estimated 1.24% to 16.8% of the population of the United States is considered "at risk" for having an anaphylactic reaction if they are exposed to one or more allergens, especially penicillin and insect stings. Most of these people successfully avoid their allergens and will never experience anaphylaxis. Of those people who actually experience anaphylaxis, up to 1% may die as a result.[1] Anaphylaxis results in fewer than 1,000 deaths per year in the U.S. (compared to 2.4 million deaths from all causes each year in the U.S.[2]). The most common presentation includes sudden cardiovascular collapse (88% of reported cases of severe anaphylaxis).


  1. Neugut, Alfred, Anita Ghatak and Rachel Miller. "Anaphylaxis in the United States: An Investigation Into Its Epidemiology." Arch Intern Med. 161.108 January 2001 15-21. 29 January 2007 <>.
  2. "FASTSTATS - Deaths and Mortality". Retrieved 2013-02-13.