Amlodipine/benazepril

Synonyms / Brand Names: Amlodipine Benzenesulfonate, Amlodipine Besilate, Amlodipine Free Base, Amlodipino, Amlodipinum,Amlocard, Amlodis, Amvaz, Coroval, Lipinox, Lotrel, benazepril, Benazepril HCl, Benazepril Hydrochloride, Benazeprilum, Briem, Cibacen, Cibacene

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Dosing and Administration

Treatment of hypertension
Amlodipine is an effective treatment of hypertension in once-daily doses of 2.5-10 mg while benazepril is effective in doses of 10-80 mg. In clinical trials of amlodipine/benazepril combination therapy using amlodipine doses of 2.5-10 mg and benazepril doses of 10-20 mg, the antihypertensive effects increased with increasing dose of amlodipine in all patient groups, and the effects increased with increasing dose of benazepril in nonblack groups. All patient groups benefited from the reduction in amlodipine-induced edema

Dose Titration Guided by Clinical Effect
A patient whose blood pressure is not adequately controlled with amlodipine (or another dihydropyridine) alone or with benazepril (or another ACE inhibitor) alone may be switched to combination therapy with Lotrel. The addition of benazepril to a regimen of amlodipine should not be expected to provide additional antihypertensive effect in African-Americans. However, all patient groups benefit from the reduction in amlodipine-induced edema. Dosage must be guided by clinical response; steady-state levels of benazepril and amlodipine will be reached after approximately 2 and 7 days of dosing, respectively.

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