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Abetimus is an immunosuppressant.[1] It is a synthetic biological called a tolerogen. It is made of four double-stranded oligodeoxyribonucleotides that are attached to a carrier platform and are designed to block specific B-cell anti double stranded DNA antibodies.[2] It may also complex anti dsDNA antibodies together, therefore disabling them. This way Abetimus is supposed to help treat Systemic Lupus Erythematosus and specifically nephritis.


  1. (not listed) (2003). "Abetimus: Abetimus sodium, LJP 394". BioDrugs. Adis. 17 (3): 212&ndash, 215. doi:10.2165/00063030-200317030-00009. ISSN 1173-8804. PMID 12749759.
  2. Wallace, Daniel J. (January 2001), "Clinical and pharmacological experience with LJP-394", Expert Opinion on Investigational Drugs, Informa, 10 (1), pp. 111&ndash, 117, doi:10.1517/13543784.10.1.111, ISSN 1354-3784, PMID 11116284, retrieved 2 April 2011