Jump to: navigation, search
Monoclonal antibody
SourceTemplate:Infobox drug/mab source
Targetovarian cancer cells expressing CA-125
Clinical data
  • N/A
Routes of
ATC code
Legal status
Legal status
  • under clinical development
Pharmacokinetic data
Bioavailabilitynot available (N/A)
Elimination half-lifeN/A
CAS Number
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Molar massN/A

WikiDoc Resources for Abagovomab


Most recent articles on Abagovomab

Most cited articles on Abagovomab

Review articles on Abagovomab

Articles on Abagovomab in N Eng J Med, Lancet, BMJ


Powerpoint slides on Abagovomab

Images of Abagovomab

Photos of Abagovomab

Podcasts & MP3s on Abagovomab

Videos on Abagovomab

Evidence Based Medicine

Cochrane Collaboration on Abagovomab

Bandolier on Abagovomab

TRIP on Abagovomab

Clinical Trials

Ongoing Trials on Abagovomab at Clinical Trials.gov

Trial results on Abagovomab

Clinical Trials on Abagovomab at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Abagovomab

NICE Guidance on Abagovomab


FDA on Abagovomab

CDC on Abagovomab


Books on Abagovomab


Abagovomab in the news

Be alerted to news on Abagovomab

News trends on Abagovomab


Blogs on Abagovomab


Definitions of Abagovomab

Patient Resources / Community

Patient resources on Abagovomab

Discussion groups on Abagovomab

Patient Handouts on Abagovomab

Directions to Hospitals Treating Abagovomab

Risk calculators and risk factors for Abagovomab

Healthcare Provider Resources

Symptoms of Abagovomab

Causes & Risk Factors for Abagovomab

Diagnostic studies for Abagovomab

Treatment of Abagovomab

Continuing Medical Education (CME)

CME Programs on Abagovomab


Abagovomab en Espanol

Abagovomab en Francais


Abagovomab in the Marketplace

Patents on Abagovomab

Experimental / Informatics

List of terms related to Abagovomab


Abagovomab is a mouse anti-idiotype monoclonal antibody whose variable epitope mirrors a tumour antigen (CA-125) highly expressed in the epithelial ovarian cancer. Abagovomab does not bind directly to CA-125, but it works as a "surrogate" antigen, enabling the immune system to identify and attack tumour cells displaying the CA 125 protein. Through this, it is hoped that the body's immune system may be able to combat any remaining individual tumour cells and thus prevent recurrence of the disease.

Curent Status

Abagovomab is currently under clinical development in patients with advanced ovarian cancer, as consolidation of the remission status obtained following surgery and standard platinum and taxane first line chemotherapy.

Phase II

In a Phase II study on 119 patients with advanced ovarian cancer in which the standard therapies had already been ineffective, treatment with abagovomab led to a prolongation of survival time (23.4 months compared to 4.9 months) in those patients who responded to the vaccination, i.e. those in whom the formation of antibodies against the tumour was proven (almost 70 % of patients). The vaccine showed hardly any side effects in preliminary studies.

Ovarian Cancer

Ovarian cancer is the most malignant tumour of the female reproductive organs. After endometrial cancer, it is the second most common genital tumour in women with approximately 9,000 women newly affected each year and, because of its aggressiveness, it has the highest mortality rate. This is due in part to the fact that there is no screening examination for early detection, and that the disease is therefore usually only discovered at an advanced stage, and in part to the tumour's tendency, although responding well to initial treatment, to recur again later.

In spite of initially successful treatment with surgery and chemotherapy, which forces back the tumour "completely", i.e. into no longer visible residues, there is a relapse of the disease (recurrence) in more than half the women affected. Today, no further therapy would be conducted in this situation as long as the disease did not occur again, i.e. clinical monitoring of the symptom-free patients as part of follow-up care is the current standard procedure. In this time-window of the patient’s hystory so called ‘watch and wait’ abagovomab is potentially capable of deferring or even preventing the occurrence of the relapse.


Abagovomab has been developed by the pharmaceutical company Menarini. A multicenter clinical trial, internationally known as MIMOSA (Monoclonal antibody Immunotherapy for Malignancies of the Ovary by Subcutaneous Abagovomab), in which Abagovomab will be administered as maintenance therapy (after first line therapy with surgery and chemotherapy), is ongoing in patients with ovarian cancer. Nine hundred women in whom the ovarian tumour was removed by surgery and standard chemotherapy with paclitaxel und carboplatin can be enrolled in the MIMOSA study, involving eight countries throughout the world (Germany, USA, Italy, Poland, Czech Republic, Spain, Hungary and Belgium) in more than 120 experienced clinical sites.

Further reading

  • Wagner U, Kohler S, Reinartz S, Giffels P, Huober J, Renke K, Schlebusch H, Biersack HJ, Mobus V, Kreienberg R, Bauknecht T, Krebs D, Wallwiener D. Immunological consolidation of ovarian carcinoma recurrences with monoclonal anti-idiotype antibody ACA125: immune responses and survival in palliative treatment. Clin Cancer Res. 2001;7(5):1154-62. http://clincancerres.aacrjournals.org/cgi/content/full/7/5/1154
  • Reinartz S, Kohler S, Schlebusch H, Krista K, Giffels P, Renke K, Huober J, Mobus V, Kreienberg R, DuBois A, Sabbatini P, Wagner U. Vaccination of patients with advanced ovarian carcinoma with the anti-idiotype ACA125: immunological response and survival (phase Ib/II). Clin Cancer Res. 2004;10(5):1580-7. http://clincancerres.aacrjournals.org/cgi/content/full/10/5/1580
  • Pfisterer J, du Bois A, Sehouli J, Loibl S, Reinartz S, Reuß A, Canzler U, Belau A, Jackisch C, Kimmig R, Wollschlaeger K, Heilmann V, Hilpert F. The anti-idiotypic antibody abagovomab in patients with recurrent ovarian cancer. A phase I trial of the AGO-OVAR. Ann Oncol. 2006;17(10):1568-77. http://annonc.oxfordjournals.org/cgi/content/abstract/17/10/1568
  • Sabbatini P, Dupont J, Aghajanian C, Derosa F, Poynor E, Anderson S, Hensley M, Livingston P, Iosonos A, Spriggs D, McGuire W, Reinartz S, Schneider S, Grande C, Lele S, Rodabaugh K, Kepner J, Ferrone S, Odunsi K. Phase I study of abagovomab in patients with epithelial ovarian, fallopian tube, or primary peritoneal cancer. Clin Cancer Res. 2006;12(18):5503-10. http://clincancerres.aacrjournals.org/cgi/content/abstract/12/18/5503

External links