Acidic leucine-rich nuclear phosphoprotein 32 family member E is a protein that in humans is encoded by the ANP32Egene.[1][2] The ANP32E gene is located on chromosome 1q22.[1] In mammalian cells, ANP32E has been shown to be an H2A.Z chaperone capable of promoting the removal of H2A.Z from chromatin.[3] In brain tissue, ANP32E together with Cpd1 regulate protein phosphatase 2A activity at synapses during synaptogenesis[4] and has been observed to form a complex with ANP32A and SET that stabilizes short-lived mRNAs containing AU-rich elements, as well as having acetyltransferase inhibitory activity (in a complex with SET) and having a role in chromatin remodeling and transcriptional regulation.[5]
↑ 1.01.1Jiang M, Ma Y, Ni X, Cao G, Ji C, Cheng H, Tang R, Xie Y, Mao Y (Nov 2002). "Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain". Cytogenet Genome Res. 97 (1–2): 68–71. doi:10.1159/000064058. PMID12438741.
↑Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C, Hamiche A (2014). "ANP32E is a histone chaperone that removes H2A.Z from chromatin". Nature. 505 (7485): 648–53. doi:10.1038/nature12922. PMID24463511.
↑Costanzo RV, Vilá-Ortíz GJ, Perandones C, Carminatti H, Matilla A, Radrizzani M (2006). "Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis". Eur. J. Neurosci. 23 (2): 309–24. doi:10.1111/j.1460-9568.2005.04555.x. PMID16420440.
Matilla A, Radrizzani M (2005). "The Anp32 family of proteins containing leucine-rich repeats". Cerebellum. 4 (1): 7–18. doi:10.1080/14734220410019020. PMID15895553.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
