ADAM protein

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Adam protein (A Disintegrin and Metalloproteinase Protein) is a family of peptidase proteins[1]. ADAMs are also known as the Adamalysin family. ADAMs are classified as Sheddases because they cut off or shed extracellular portions of transmembrane proteins. For example, ADAM 10 can cut off part of the HER2 receptor, activating it[2] and ADAM 17 can cut off part of the EGFR once it has bound its ligand, freeing the ligand to go and stimulate another cell[3]. Therapeutic ADAM inhibitors can potentiate anti-cancer therapy[citation needed].

It is categorized under EC 3.4.24.46.

Types include:

References

  1. Wolfsberg TG, Straight PD, Gerena RL; et al. (1995). "ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain". Dev. Biol. 169 (1): 378–383. doi:10.1006/dbio.1995.1152. PMID 7750654.
  2. Liu, P.C. (2006). "Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells". Cancer Biology and Therapy. 6: 657–664. Unknown parameter |coauthors= ignored (help)
  3. Lautrette, A (2005). "Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach". Nature Medicine. 8: 867–874. Unknown parameter |coauthors= ignored (help)

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