40S ribosomal protein S4, Y isoform 2

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ribosomal protein S4, Y-linked 2
Alt. symbolsRPS4Y2P
Other data
LocusChr. Y q11.223

Ribosomal protein S4, Y-linked 2 also known as RPS4Y2 is a protein which in humans is encoded by the RPS4Y2 gene which resides on the Y chromosome.[1][2]


Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene, RPS4Y1 and the ribosomal protein S4, X-linked (RPS4X). The 3 isoforms encoded by these genes are not identical, but appear to be functionally equivalent.[3] Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial.[4]


  1. Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (June 2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. doi:10.1038/nature01722. PMID 12815422.
  2. "Entrez Gene: RPS4Y2 ribosomal protein S4, Y-linked 2".
  3. Andrés O, Kellermann T, López-Giráldez F, Rozas J, Domingo-Roura X, Bosch M (2008). "RPS4Y gene family evolution in primates". BMC Evol. Biol. 8: 142. doi:10.1186/1471-2148-8-142. PMC 2397393. PMID 18477388.
  4. "Entrez Gene: RPS4Y1 ribosomal protein S4, Y-linked 1".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.