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E number{{#property:P628}}
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Chemical and physical data
Molar mass260.13 g/mol

2C-F, or 4-fluoro-2,5-dimethoxyphenethylamine, is a lesser-known psychedelic drug of the 2C family. It was first synthesized by Alexander Shulgin. In his book PIHKAL (Phenethylamines I Have Known and Loved), the minimum dosage is listed as 250 mg. 2C-F may be found as a brownish freebase oil, or as a white crystalline hydrochloride salt.

Dosage and Effects

Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-F. At a dose of 250 milligrams, 2C-F produces modest closed-eye visuals accompanied by lethargy [1]. The amphetamine analogue DOF is likely to be more active than the phenethylamine derivative 2C-F, and in animal trials DOF was found to be 1/6th the dosage of the potent hallucinogen DOI, which would make an active dose of DOF likely to be in the 6-18 milligram range, although it is not known to have been tested in humans.


  1. Shulgin, Alexander (1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. Unknown parameter |month= ignored (help); Unknown parameter |coauthors= ignored (help)

External link