Calcidiol

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Calcidiol
IUPAC name (6R)-6-[(1R,3aR,4E,7aR)-4-[(2Z)-2-[(5S)-5-
Hydroxy-2-methylidene-cyclohexylidene]
ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-
1H-inden-1-yl]-2-methyl-heptan-2-ol
Other names 25-Hydroxyvitamin D3
25-Hydroxycholecalciferol
Calcifediol
Identifiers
3D model (JSmol)
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MeSH Calcidiol
Properties
C27H44O2
Molar mass 400.637 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Calcidiol, calcifediol, 25-hydroxycholecalciferol, or 25–hydroxy–vitamin D, is a prehormone which is produced by the metabolism of vitamin D3 (cholecalciferol) and which is converted by the kidneys (via 25-Hydroxyvitamin D3 1-alpha-Hydroxylase) into calcitriol (1,25-vitamin D), a steroid hormone.

Clinical significance

In medicine, bloodstream concentration of calcidiol is commonly used to measure overall vitamin D levels. Calcifediol promotes the mineralization of bones and teeth and is used to treat diseases caused by vitamin D deficiency such as rickets and osteomalacia. It is effective even in azotemic patients.[citation needed]

References

  • Dietary Reference intakes for Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. Institute of Medicine, 1997
  • Vitamin D Pharmacology at VitaminDCouncil.com

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