2-oxo-acid reductase

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In enzymology, a 2-oxo-acid reductase (EC is an enzyme that catalyzes the chemical reaction

a (2R)-hydroxy-carboxylate + acceptor a 2-oxo-carboxylate + reduced acceptor

Thus, the two substrates of this enzyme are (2R)-hydroxy-carboxylate and acceptor, whereas its two products are 2-oxo-carboxylate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (2R)-hydroxy-carboxylate:acceptor oxidoreductase. Other names in common use include (2R)-hydroxycarboxylate-viologen-oxidoreductase, HVOR, and 2-oxoacid reductase.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Trautwein T, Krauss F, Lottspeich F, Simon H (1994). "The (2R)-hydroxycarboxylate-viologen-oxidoreductase from Proteus vulgaris is a molybdenum-containing iron-sulphur protein". Eur. J. Biochem. 222: 1025&ndash, 32. PMID 8026480.
  • Neumann S and Simon H (1985). "On a non-pyridine nucleotide-dependent 2-oxoacid reductase of broad specificity from two Proteus species". FEBS Lett. 167: 29&ndash, 32.

External links

The CAS registry number for this enzyme class is 115299-99-5.