2-methylacyl-CoA dehydrogenase

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In enzymology, a 2-methylacyl-CoA dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

2-methylbutanoyl-CoA + acceptor 2-methylbut-2-enoyl-CoA + reduced acceptor

Thus, the two substrates of this enzyme are 2-methylbutanoyl-CoA and acceptor, whereas its two products are 2-methylbut-2-enoyl-CoA and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is 2-methylbutanoyl-CoA:acceptor oxidoreductase. Other names in common use include branched-chain acyl-CoA dehydrogenase, 2-methyl branched chain acyl-CoA dehydrogenase, and 2-methylbutanoyl-CoA:(acceptor) oxidoreductase. This enzyme participates in valine, leucine and isoleucine degradation.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
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  • Ikeda Y, Dabrowski C, Tanaka K (1983). "Separation and properties of five distinct acyl-CoA dehydrogenases from rat liver mitochondria. Identification of a new 2-methyl branched chain acyl-CoA dehydrogenase". J. Biol. Chem. 258: 1066&ndash, 76. PMID 6401712.

External links

The CAS registry number for this enzyme class is 85130-32-1.

Gene Ontology (GO) codes