2-dehydropantoate aldolase

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In enzymology, a 2-dehydropantoate aldolase (EC is an enzyme that catalyzes the chemical reaction

2-dehydropantoate 3-methyl-2-oxobutanoate + formaldehyde

Hence, this enzyme has one substrate, 2-dehydropantoate, and two products, 3-methyl-2-oxobutanoate and formaldehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-dehydropantoate formaldehyde-lyase (3-methyl-2-oxobutanoate-forming). Other names in common use include ketopantoaldolase, and 2-dehydropantoate formaldehyde-lyase.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • McIntosh EN, Purko M and Wood WA (1957). "Ketopantoate formation by a hydroxymethylation enzyme from Escherichia coli". J. Biol. Chem. 228: 499&ndash, 510.

External links

The CAS registry number for this enzyme class is 9024-51-5.

Gene Ontology (GO) codes