2-acylglycerophosphocholine O-acyltransferase

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In enzymology, a 2-acylglycerophosphocholine O-acyltransferase (EC is an enzyme that catalyzes the chemical reaction

acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine CoA + phosphatidylcholine

Thus, the two substrates of this enzyme are acyl-CoA and 2-acyl-sn-glycero-3-phosphocholine, whereas its two products are CoA and phosphatidylcholine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase. Other names in common use include 2-acylglycerol-3-phosphorylcholine acyltransferase, and 2-acylglycerophosphocholine acyltransferase. This enzyme participates in glycerophospholipid metabolism.


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  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Lands WEM and Hart P (1965). "Metabolism of glycerolipids. VI. Specificities of acyl coenzyme A:phospholipid acyltransferases". J. Biol. Chem. 240: 1905&ndash, 1911.
  • Van Den Bosch H, Van Golde MG, Slotboom AJ, Van Deenen LL (1968). "The acylation of isomeric monoacyl phosphatidylcholines". Biochim. Biophys. Acta. 152: 694&ndash, 703. PMID 5660084.

External links

The CAS registry number for this enzyme class is 64295-73-4.

Gene Ontology (GO) codes