2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

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In enzymology, a 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC is an enzyme that catalyzes the chemical reaction

CTP + 2-C-methyl-D-erythritol 4-phosphate diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Thus, the two substrates of this enzyme are CTP and 2-C-methyl-D-erythritol 4-phosphate, whereas its two products are diphosphate and 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase. This enzyme is also called MEP cytidylyltransferase. This enzyme participates in biosynthesis of steroids.

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1H3M, 1VGT, 1VGU, 1VGZ, 1VPA, 1W55, 1W57, 1W77, and 2PX7.


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  • K, Eisenreich W, Bacher A, Zenk MH (1999). "Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol". Proc. Natl. Acad. Sci. U. S. A. 96: 11758&ndash, 63. PMID 10518523.
  • Kuzuyama T, Takagi M, Kaneda K, Dairi T and Seto H (2000). "Formation of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol from 2-C-methyl-D-erythritol 4-phosphate by 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, a new enzyme in the nonmevalonate pathway". Tetrahedron Lett. 41: 703&ndash, 706.

External links

Gene Ontology (GO) codes