16alpha-hydroxysteroid dehydrogenase

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In enzymology, a 16alpha-hydroxysteroid dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

a 16alpha-hydroxysteroid + NAD(P)+ a 16-oxosteroid + NAD(P)H + H+

The 3 substrates of this enzyme are 16alpha-hydroxysteroid, NAD+, and NADP+, whereas its 4 products are 16-oxosteroid, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 16alpha-hydroxysteroid:NAD(P)+ 16-oxidoreductase. This enzyme is also called 16alpha-hydroxy steroid dehydrogenase.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Google Scholar references for
  • Meigs RA, Ryan KJ (1966). "16-alpha-hydroxysteroid dehydrogenase of rat kidney. Purification, assay, and properties". J. Biol. Chem. 241: 4011&ndash, 5. PMID 4380686.

External links

The CAS registry number for this enzyme class is 37250-74-1.

Gene Ontology (GO) codes