1,5-anhydro-D-fructose reductase

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In enzymology, a 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) is an enzyme that catalyzes the chemical reaction

1,5-anhydro-D-glucitol + NADP+ 1,5-anhydro-D-fructose + NADPH + H+

Thus, the two substrates of this enzyme are 1,5-anhydro-D-glucitol and NADP+, whereas its 3 products are 1,5-anhydro-D-fructose, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 1,5-anhydro-D-glucitol:NADP+ oxidoreductase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GLX.

References

  • IUBMB entry for 1.1.1.263
  • BRENDA references for 1.1.1.263 (Recommended.)
  • PubMed references for 1.1.1.263
  • PubMed Central references for 1.1.1.263
  • Google Scholar references for 1.1.1.263
  • Sakuma M, Kametani S and Akanuma H (Tokyo). "Purification and some properties of a hepatic NADPH-dependent reductase that specifically acts on 1,5-anhydro-D-fructose". J. Biochem.: 189&ndash, 193. Check date values in: |date= (help)

External links

Gene Ontology (GO) codes


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