1,4,6-Androstatrien-3,17-dione

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1,4,6-Androstatrien-3,17-dione
File:1,4,6-androstatrien-3,17-dione1.png
Clinical data
Pregnancy
category
  • US: X (Contraindicated)
Routes of
administration
Parenteral
Legal status
Legal status
  • US: Supplement
Pharmacokinetic data
MetabolismHepatic
Elimination half-lifeMinutes
Identifiers
CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaC19H22O2
Molar mass282.38 g·mol−1

1,4,6-Androstatrien-3,17-dione (ATD) is a potent irreversible aromatase inhibitor that inhibits estrogen biosynthesis by permanently binding and inactivating aromatase in adipose and peripheral tissue.[1] It is used to control estrogen synthesis.[2]

ATD is present in some over-the-counter bodybuilding supplements such as Rebound XT, Novedex XT and Inhibit-E. While not banned, ADT may cause positive urinanalysis results leading to disqualification from competitive sports due to its similar properties to banned substances.[3]

A related agent is exemestane (Aromasin).

References

  1. Covey DF, Hood WF. (1981). "Enzyme-generated intermediates derived from 4-androstene-3,6,17-trione and 1,4,6-androstatriene-3,17-dione cause a time-dependent decrease in human placental aromatase activity". Endocrinology 108 (4): 1597-9. PMID 7472286.
  2. Adkins-Regan, Elizabeth (2006-07-06). "Sex steroids modulate changes in social and sexual preference during juvenile development in zebra finches". Hormones and Behaviour. Elsevier Inc. 50 (5): 772–778. Retrieved 2007-10-07. Unknown parameter |coauthors= ignored (help)
  3. "DRUG TESTING" (HTML). Organization of Competitive Bodybuilders. Retrieved 2007-10-07.

Further Reading

  1. ^ Covey DF, Hood WF. (1981). "Enzyme-generated intermediates derived from 4-androstene-3,6,17-trione and 1,4,6-androstatriene-3,17-dione cause a time-dependent decrease in human placental aromatase activity". Endocrinology 108 (4): 1597-9. PMID 7472286.
  2. Ellinwood WE, Hess DL, Roselli CE, Spies HG, Resko JA (1984). "Inhibition of aromatization stimulates luteinizing hormone and testosterone secretion in adult male rhesus monkeys". J. Clin. Endocrinol. Metab. 59 (6): 1088–96. PMID 6541658.

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