(S)-6-hydroxynicotine oxidase

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In enzymology, a (S)-6-hydroxynicotine oxidase (EC is an enzyme that catalyzes the chemical reaction

(S)-6-hydroxynicotine + H2O + O2 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O2

The 3 substrates of this enzyme are (S)-6-hydroxynicotine, H2O, and O2, whereas its two products are 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is (S)-6-hydroxynicotine:oxygen oxidoreductase. Other names in common use include L-6-hydroxynicotine oxidase, 6-hydroxy-L-nicotine oxidase, and 6-hydroxy-L-nicotine:oxygen oxidoreductase. It employs one cofactor, FAD.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Google Scholar references for
  • Dai VD, Decker K, Sund H (1968). "Purification and properties of L-6-hydroxynicotine oxidase". Eur. J. Biochem. 4: 95&ndash, 102. PMID 5646150.
  • Decker K, Bleeg H (1965). "Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans". Biochim. Biophys. Acta. 105: 313&ndash, 24. PMID 5849820.

External links

The CAS registry number for this enzyme class is 37256-29-4.

Gene Ontology (GO) codes