(2,3-dihydroxybenzoyl)adenylate synthase

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In enzymology, a (2,3-dihydroxybenzoyl)adenylate synthase (EC is an enzyme that catalyzes the chemical reaction

ATP + 2,3-dihydroxybenzoate diphosphate + (2,3-dihydroxybenzoyl)adenylate

Thus, the two substrates of this enzyme are ATP and 2,3-dihydroxybenzoate, whereas its two products are diphosphate and (2,3-dihydroxybenzoyl)adenylate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:2,3-dihydroxybenzoate adenylyltransferase. This enzyme is also called 2,3-dihydroxybenzoate-AMP ligase. This enzyme participates in biosynthesis of siderophore group nonribosomal and [[]].


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  • Rusnak F, Faraci WS, Walsh CT (1989). "Subcloning, expression, and purification of the enterobactin biosynthetic enzyme 2,3-dihydroxybenzoate-AMP ligase: demonstration of enzyme-bound (2,3-dihydroxybenzoyl)adenylate product". Biochemistry. 28: 6827&ndash, 35. PMID 2531000.

External links

The CAS registry number for this enzyme class is 122332-73-4.

Gene Ontology (GO) codes