(-)-endo-fenchol synthase

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In enzymology, a (-)-endo-fenchol synthase (EC is an enzyme that catalyzes the chemical reaction

geranyl diphosphate + H2O (-)-endo-fenchol + diphosphate

Thus, the two substrates of this enzyme are geranyl diphosphate and H2O, whereas its two products are (-)-endo-fenchol and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming]. Other names in common use include (-)-endo-fenchol cyclase, and geranyl pyrophosphate:(-)-endo-fenchol cyclase. This enzyme participates in monoterpenoid biosynthesis.


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  • BRENDA references for (Recommended.)
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  • Croteau R, Miyazaki JH, Wheeler CJ (1989). "Monoterpene biosynthesis: mechanistic evaluation of the geranyl pyrophosphate:(-)-endo-fenchol cyclase from fennel (Foeniculum vulgare)". Arch. Biochem. Biophys. 269: 507&ndash, 16. PMID 2919880.
  • Croteau R, Satterwhite DM, Wheeler CJ, Felton NM (1988). "Biosynthesis of monoterpenes. Stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (-)-endo-fenchol". J. Biol. Chem. 263: 15449&ndash, 53. PMID 3170591.

External links

The CAS registry number for this enzyme class is 117758-41-5.

Gene Ontology (GO) codes