Uveal melanoma history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
A positive history of pre-existing iris nevus which increased in size, eye pain, visual loss, blurred vision, floaters, age between 50_70 years old, male gender, white race, pregnancy, | A positive [[History and Physical examination|history]] of pre-existing [[iris]] [[nevus]] which increased in size, [[eye pain]], [[Vision loss|visual loss]], [[blurred vision]], [[Floater|floaters]], age between 50_70 years old, [[male]] gender, white [[race]], [[pregnancy]], [[Immune system disorder|impaired immune system]], light colored-irides, [[sunlight]] exposure, [[trauma]], and [[Fluorescence|fluorescent]] lighting exposure is suggestive of uveal melanoma. The most common [[Symptom|symptoms]] of name] include ,[[eye pain]], [[blurred vision]], [[eye]] redness, loss of [[peripheral vision]], poor or [[blurry vision]] in one [[eye]], a dark spot on the [[iris]], seeing flashing lights, and [[Floater|floaters]]. | ||
==History and Symptoms== | ==History and Symptoms== | ||
* Symptoms of uveal melanoma include eye pain, blurred vision, eye redness, loss of [[peripheral vision]], poor or [[blurry vision]] in one [[eye]], a dark spot on the [[iris]], seeing flashing lights, and floaters. | *[[Symptoms]] of uveal melanoma include [[eye pain]], [[blurred vision]], [[eye]] redness, loss of [[peripheral vision]], poor or [[blurry vision]] in one [[eye]], a dark spot on the [[iris]], seeing flashing lights, and [[floaters]]. | ||
=== History === | === History === | ||
Patients with uveal melanoma may have a positive history of:<ref name="EganSeddon1988">{{cite journal|last1=Egan|first1=Kathleen M.|last2=Seddon|first2=Johanna M.|last3=Glynn|first3=Robert J.|last4=Gragoudas|first4=Evangelos S.|last5=Albert|first5=Daniel M.|title=Epidemiologic aspects of uveal melanoma|journal=Survey of Ophthalmology|volume=32|issue=4|year=1988|pages=239–251|issn=00396257|doi=10.1016/0039-6257(88)90173-7}}</ref><ref name="NCI">Uveal melanoma. National Cancer Institute(2015) http://www.cancer.gov/types/eye/hp/intraocular-melanoma-treatment-pdq Accessed on October 24 2015</ref><ref name="vanKoopmans2013">{{cite journal|last1=van|first1=J.G.M.|last2=Koopmans|first2=A.E.|last3=Verdijk|first3=R.M.|last4=Naus|first4=N.C.|last5=de|first5=A.|last6=Kilic|first6=E.|title=Diagnosis, Histopathologic and Genetic Classification of Uveal Melanoma|year=2013|doi=10.5772/53631}}</ref><ref name="Reese1944">{{cite journal|last1=Reese|first1=Algernon B.|title=Pigment Freckles of the Iris (Benign Melanomas): Their Significance in Relation to Malignant Melanoma of the Uvea⋆|journal=American Journal of Ophthalmology|volume=27|issue=3|year=1944|pages=217–226|issn=00029394|doi=10.1016/S0002-9394(44)91382-6}}</ref><ref name="Siegel1963">{{cite journal|last1=Siegel|first1=Ralph|title=Malignant Ocular Melanoma During Pregnancy|journal=JAMA: The Journal of the American Medical Association|volume=185|issue=6|year=1963|pages=542|issn=0098-7484|doi=10.1001/jama.1963.03060060140028}}</ref><ref name="FisherKripke1982">{{cite journal|last1=Fisher|first1=M.|last2=Kripke|first2=M.|title=Suppressor T lymphocytes control the development of primary skin cancers in ultraviolet-irradiated mice|journal=Science|volume=216|issue=4550|year=1982|pages=1133–1134|issn=0036-8075|doi=10.1126/science.6210958}}</ref><ref>{{cite journal|title=Risk Factors for Ocular Melanoma: Western Canada Melanoma Study<xref ref-type="fn" rid="FN1">2</xref><xref ref-type="fn" rid="FN2">3</xref>|journal=JNCI: Journal of the National Cancer Institute|year=1985|issn=1460-2105|doi=10.1093/jnci/74.4.775}}</ref><ref name="TuckerShields1985">{{cite journal|last1=Tucker|first1=Margaret A.|last2=Shields|first2=Jerry A.|last3=Hartge|first3=Patricia|last4=Augsburger|first4=James|last5=Hoover|first5=Robert N.|last6=Fraumeni|first6=Joseph F.|title=Sunlight Exposure as Risk Factor for Intraocular Malignant Melanoma|journal=New England Journal of Medicine|volume=313|issue=13|year=1985|pages=789–792|issn=0028-4793|doi=10.1056/NEJM198509263131305}}</ref><ref name="BabaBlumenkranz1986">{{cite journal|last1=Baba|first1=F. E.|last2=Blumenkranz|first2=M.|title=Malignant Melanoma at the Site of Penetrating Ocular Trauma|journal=Archives of Ophthalmology|volume=104|issue=3|year=1986|pages=405–409|issn=0003-9950|doi=10.1001/archopht.1986.01050150105038}}</ref><ref name="BeralShaw1982">{{cite journal|last1=Beral|first1=Valerie|last2=Shaw|first2=Helen|last3=Evans|first3=Susan|last4=Milton|first4=Gerald|title=MALIGNANT MELANOMA AND EXPOSURE TO FLUORESCENT LIGHTING AT WORK|journal=The Lancet|volume=320|issue=8293|year=1982|pages=290–293|issn=01406736|doi=10.1016/S0140-6736(82)90270-7}}</ref> | Patients with uveal melanoma may have a positive history of:<ref name="EganSeddon1988">{{cite journal|last1=Egan|first1=Kathleen M.|last2=Seddon|first2=Johanna M.|last3=Glynn|first3=Robert J.|last4=Gragoudas|first4=Evangelos S.|last5=Albert|first5=Daniel M.|title=Epidemiologic aspects of uveal melanoma|journal=Survey of Ophthalmology|volume=32|issue=4|year=1988|pages=239–251|issn=00396257|doi=10.1016/0039-6257(88)90173-7}}</ref><ref name="NCI">Uveal melanoma. National Cancer Institute(2015) http://www.cancer.gov/types/eye/hp/intraocular-melanoma-treatment-pdq Accessed on October 24 2015</ref><ref name="vanKoopmans2013">{{cite journal|last1=van|first1=J.G.M.|last2=Koopmans|first2=A.E.|last3=Verdijk|first3=R.M.|last4=Naus|first4=N.C.|last5=de|first5=A.|last6=Kilic|first6=E.|title=Diagnosis, Histopathologic and Genetic Classification of Uveal Melanoma|year=2013|doi=10.5772/53631}}</ref><ref name="Reese1944">{{cite journal|last1=Reese|first1=Algernon B.|title=Pigment Freckles of the Iris (Benign Melanomas): Their Significance in Relation to Malignant Melanoma of the Uvea⋆|journal=American Journal of Ophthalmology|volume=27|issue=3|year=1944|pages=217–226|issn=00029394|doi=10.1016/S0002-9394(44)91382-6}}</ref><ref name="Siegel1963">{{cite journal|last1=Siegel|first1=Ralph|title=Malignant Ocular Melanoma During Pregnancy|journal=JAMA: The Journal of the American Medical Association|volume=185|issue=6|year=1963|pages=542|issn=0098-7484|doi=10.1001/jama.1963.03060060140028}}</ref><ref name="FisherKripke1982">{{cite journal|last1=Fisher|first1=M.|last2=Kripke|first2=M.|title=Suppressor T lymphocytes control the development of primary skin cancers in ultraviolet-irradiated mice|journal=Science|volume=216|issue=4550|year=1982|pages=1133–1134|issn=0036-8075|doi=10.1126/science.6210958}}</ref><ref>{{cite journal|title=Risk Factors for Ocular Melanoma: Western Canada Melanoma Study<xref ref-type="fn" rid="FN1">2</xref><xref ref-type="fn" rid="FN2">3</xref>|journal=JNCI: Journal of the National Cancer Institute|year=1985|issn=1460-2105|doi=10.1093/jnci/74.4.775}}</ref><ref name="TuckerShields1985">{{cite journal|last1=Tucker|first1=Margaret A.|last2=Shields|first2=Jerry A.|last3=Hartge|first3=Patricia|last4=Augsburger|first4=James|last5=Hoover|first5=Robert N.|last6=Fraumeni|first6=Joseph F.|title=Sunlight Exposure as Risk Factor for Intraocular Malignant Melanoma|journal=New England Journal of Medicine|volume=313|issue=13|year=1985|pages=789–792|issn=0028-4793|doi=10.1056/NEJM198509263131305}}</ref><ref name="BabaBlumenkranz1986">{{cite journal|last1=Baba|first1=F. E.|last2=Blumenkranz|first2=M.|title=Malignant Melanoma at the Site of Penetrating Ocular Trauma|journal=Archives of Ophthalmology|volume=104|issue=3|year=1986|pages=405–409|issn=0003-9950|doi=10.1001/archopht.1986.01050150105038}}</ref><ref name="BeralShaw1982">{{cite journal|last1=Beral|first1=Valerie|last2=Shaw|first2=Helen|last3=Evans|first3=Susan|last4=Milton|first4=Gerald|title=MALIGNANT MELANOMA AND EXPOSURE TO FLUORESCENT LIGHTING AT WORK|journal=The Lancet|volume=320|issue=8293|year=1982|pages=290–293|issn=01406736|doi=10.1016/S0140-6736(82)90270-7}}</ref> | ||
* Pre-existing iris nevus which increased in size | * Pre-existing [[iris]] [[nevus]] which increased in size | ||
* Eye pain | *[[Eye pain]] | ||
* Visual loss | *[[Vision loss|Visual loss]] | ||
* Blurred vision | *[[Blurred vision]] | ||
* Floaters | *[[Floaters]] | ||
* Age between 50_70 years old | *[[Ageing|Age]] between 50_70 years old | ||
* Male gender | *[[Male]] gender | ||
* white race | * white [[Race for Life|race]] | ||
* Pregnancy | *[[Pregnancy]] | ||
* Impaired immune system | *[[Immune system disorder|Impaired immune system]] | ||
* light colored-irides | * light colored-irides | ||
* Sunlight exposure | *[[Sunlight]] exposure | ||
* Trauma | *[[Trauma]] | ||
* Fluorescent lighting exposure | *[[Fluorescent]] lighting exposure | ||
===Common Symptoms=== | ===Common Symptoms=== | ||
Common symptoms of uveal melanoma include:<ref name="radio">Retinoblastoma. Radiopedia(2015) http://radiopaedia.org/articles/primary-uveal-malignant-melanoma Accessed on October 21, 2015</ref> <ref name="pmid23826405">{{cite journal| author=Jovanovic P, Mihajlovic M, Djordjevic-Jocic J, Vlajkovic S, Cekic S, Stefanovic V| title=Ocular melanoma: an overview of the current status. | journal=Int J Clin Exp Pathol | year= 2013 | volume= 6 | issue= 7 | pages= 1230-44 | pmid=23826405 | doi= | pmc=PMC3693189 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23826405 }} </ref> | Common [[Symptom|symptoms]] of uveal melanoma include:<ref name="radio">Retinoblastoma. Radiopedia(2015) http://radiopaedia.org/articles/primary-uveal-malignant-melanoma Accessed on October 21, 2015</ref> <ref name="pmid23826405">{{cite journal| author=Jovanovic P, Mihajlovic M, Djordjevic-Jocic J, Vlajkovic S, Cekic S, Stefanovic V| title=Ocular melanoma: an overview of the current status. | journal=Int J Clin Exp Pathol | year= 2013 | volume= 6 | issue= 7 | pages= 1230-44 | pmid=23826405 | doi= | pmc=PMC3693189 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23826405 }} </ref> | ||
*[[Eye pain]] | *[[Eye pain]] | ||
*[[Blurred vision]] | *[[Blurred vision]] | ||
*Eye redness | *[[Eye]] redness | ||
*Loss of [[peripheral vision]] | *Loss of [[peripheral vision]] | ||
*Poor or [[blurry vision]] in one [[eye]] | *Poor or [[blurry vision]] in one [[eye]] | ||
*A dark spot on | *A dark spot on the [[iris]] | ||
*Seeing flashing lights | *Seeing flashing lights | ||
*[[Floaters]] | *[[Floaters]] | ||
=== Less Common Symptoms === | === Less Common Symptoms === | ||
Less common symptoms of uveal melanoma include: | Less common [[Symptoms and Signs|symptoms]] of uveal melanoma include: | ||
*Severe [[headache]] | *Severe [[headache]] | ||
Revision as of 15:30, 13 August 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
A positive history of pre-existing iris nevus which increased in size, eye pain, visual loss, blurred vision, floaters, age between 50_70 years old, male gender, white race, pregnancy, impaired immune system, light colored-irides, sunlight exposure, trauma, and fluorescent lighting exposure is suggestive of uveal melanoma. The most common symptoms of name] include ,eye pain, blurred vision, eye redness, loss of peripheral vision, poor or blurry vision in one eye, a dark spot on the iris, seeing flashing lights, and floaters.
History and Symptoms
- Symptoms of uveal melanoma include eye pain, blurred vision, eye redness, loss of peripheral vision, poor or blurry vision in one eye, a dark spot on the iris, seeing flashing lights, and floaters.
History
Patients with uveal melanoma may have a positive history of:[1][2][3][4][5][6][7][8][9][10]
- Pre-existing iris nevus which increased in size
- Eye pain
- Visual loss
- Blurred vision
- Floaters
- Age between 50_70 years old
- Male gender
- white race
- Pregnancy
- Impaired immune system
- light colored-irides
- Sunlight exposure
- Trauma
- Fluorescent lighting exposure
Common Symptoms
Common symptoms of uveal melanoma include:[11] [12]
- Eye pain
- Blurred vision
- Eye redness
- Loss of peripheral vision
- Poor or blurry vision in one eye
- A dark spot on the iris
- Seeing flashing lights
- Floaters
Less Common Symptoms
Less common symptoms of uveal melanoma include:
References
- ↑ Egan, Kathleen M.; Seddon, Johanna M.; Glynn, Robert J.; Gragoudas, Evangelos S.; Albert, Daniel M. (1988). "Epidemiologic aspects of uveal melanoma". Survey of Ophthalmology. 32 (4): 239–251. doi:10.1016/0039-6257(88)90173-7. ISSN 0039-6257.
- ↑ Uveal melanoma. National Cancer Institute(2015) http://www.cancer.gov/types/eye/hp/intraocular-melanoma-treatment-pdq Accessed on October 24 2015
- ↑ van, J.G.M.; Koopmans, A.E.; Verdijk, R.M.; Naus, N.C.; de, A.; Kilic, E. (2013). "Diagnosis, Histopathologic and Genetic Classification of Uveal Melanoma". doi:10.5772/53631.
- ↑ Reese, Algernon B. (1944). "Pigment Freckles of the Iris (Benign Melanomas): Their Significance in Relation to Malignant Melanoma of the Uvea⋆". American Journal of Ophthalmology. 27 (3): 217–226. doi:10.1016/S0002-9394(44)91382-6. ISSN 0002-9394.
- ↑ Siegel, Ralph (1963). "Malignant Ocular Melanoma During Pregnancy". JAMA: The Journal of the American Medical Association. 185 (6): 542. doi:10.1001/jama.1963.03060060140028. ISSN 0098-7484.
- ↑ Fisher, M.; Kripke, M. (1982). "Suppressor T lymphocytes control the development of primary skin cancers in ultraviolet-irradiated mice". Science. 216 (4550): 1133–1134. doi:10.1126/science.6210958. ISSN 0036-8075.
- ↑ "Risk Factors for Ocular Melanoma: Western Canada Melanoma Study<xref ref-type="fn" rid="FN1">2</xref><xref ref-type="fn" rid="FN2">3</xref>". JNCI: Journal of the National Cancer Institute. 1985. doi:10.1093/jnci/74.4.775. ISSN 1460-2105.
- ↑ Tucker, Margaret A.; Shields, Jerry A.; Hartge, Patricia; Augsburger, James; Hoover, Robert N.; Fraumeni, Joseph F. (1985). "Sunlight Exposure as Risk Factor for Intraocular Malignant Melanoma". New England Journal of Medicine. 313 (13): 789–792. doi:10.1056/NEJM198509263131305. ISSN 0028-4793.
- ↑ Baba, F. E.; Blumenkranz, M. (1986). "Malignant Melanoma at the Site of Penetrating Ocular Trauma". Archives of Ophthalmology. 104 (3): 405–409. doi:10.1001/archopht.1986.01050150105038. ISSN 0003-9950.
- ↑ Beral, Valerie; Shaw, Helen; Evans, Susan; Milton, Gerald (1982). "MALIGNANT MELANOMA AND EXPOSURE TO FLUORESCENT LIGHTING AT WORK". The Lancet. 320 (8293): 290–293. doi:10.1016/S0140-6736(82)90270-7. ISSN 0140-6736.
- ↑ Retinoblastoma. Radiopedia(2015) http://radiopaedia.org/articles/primary-uveal-malignant-melanoma Accessed on October 21, 2015
- ↑ Jovanovic P, Mihajlovic M, Djordjevic-Jocic J, Vlajkovic S, Cekic S, Stefanovic V (2013). "Ocular melanoma: an overview of the current status". Int J Clin Exp Pathol. 6 (7): 1230–44. PMC 3693189. PMID 23826405.