T-SPOT.TB: Difference between revisions
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==T-Spot Assay== | ==T-Spot Assay== | ||
'''T Spot Assay''TB''''' is a type of [[ELISPOT]] assay used for [[tuberculosis]] diagnosis in Europe. It counts the number of effector [[T cells]], [[white blood cell]]s that produce [[gamma interferon]], in a sample of blood. This gives an overall measurement of the [[antigen]] load on the immune system, which can reveal the presence of subclinical disease. Because this does not rely on production of a reliable [[antibody]] response or recoverable pathogen, the technique can be used to detect conditions such as [[latent tuberculosis]].<ref name="Santin-2012">{{Cite journal | last1 = Santin | first1 = M. | last2 = Muñoz | first2 = L. | last3 = Rigau | first3 = D. | title = Interferon-γ release assays for the diagnosis of tuberculosis and tuberculosis infection in HIV-infected adults: a systematic review and meta-analysis. | journal = PLoS One | volume = 7 | issue = 3 | pages = e32482 | month = | year = 2012 | doi = 10.1371/journal.pone.0032482 | PMID = 22403663 }}</ref> | '''T Spot Assay''TB''''' is a type of [[ELISPOT]] assay used for [[tuberculosis]] diagnosis in Europe. It counts the number of effector [[T cells]], [[white blood cell]]s that produce [[gamma interferon]], in a sample of blood. This gives an overall measurement of the [[antigen]] load on the immune system, which can reveal the presence of subclinical disease. Because this does not rely on production of a reliable [[antibody]] response or recoverable pathogen, the technique can be used to detect conditions such as [[latent tuberculosis]].<ref name="Santin-2012">{{Cite journal | last1 = Santin | first1 = M. | last2 = Muñoz | first2 = L. | last3 = Rigau | first3 = D. | title = Interferon-γ release assays for the diagnosis of tuberculosis and tuberculosis infection in HIV-infected adults: a systematic review and meta-analysis. | journal = PLoS One | volume = 7 | issue = 3 | pages = e32482 | month = | year = 2012 | doi = 10.1371/journal.pone.0032482 | PMID = 22403663 }}</ref> | ||
== References == | == References == | ||
Latest revision as of 20:42, 25 January 2014
T-Spot Assay
T Spot AssayTB is a type of ELISPOT assay used for tuberculosis diagnosis in Europe. It counts the number of effector T cells, white blood cells that produce gamma interferon, in a sample of blood. This gives an overall measurement of the antigen load on the immune system, which can reveal the presence of subclinical disease. Because this does not rely on production of a reliable antibody response or recoverable pathogen, the technique can be used to detect conditions such as latent tuberculosis.[1]
References
- ↑ Santin, M.; Muñoz, L.; Rigau, D. (2012). "Interferon-γ release assays for the diagnosis of tuberculosis and tuberculosis infection in HIV-infected adults: a systematic review and meta-analysis". PLoS One. 7 (3): e32482. doi:10.1371/journal.pone.0032482. PMID 22403663.