Spondyloarthropathy risk factors: Difference between revisions
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The risk of developing spondyloarthropathies in individuals with HLA-B27 gene is 1-2%, however, it can increase to 15-20% if he/she have a first-degree relative with positive HLA-B27 gene and developed spondyloarthropathy. | The risk of developing spondyloarthropathies in individuals with HLA-B27 gene is 1-2%, however, it can increase to 15-20% if he/she have a first-degree relative with positive HLA-B27 gene and developed spondyloarthropathy. | ||
There some genes that are suspicious for their association in SpA | There some genes that are suspicious for their association in SpA, which are included: | ||
* HLA-B27 | |||
** HLA-B*2702 (Association with AS) | |||
** HLA-B*2704 (Association with SpA) | |||
** HLA-B*2705 (Strong association with AS) | |||
** HLA-B*2706 (Very weak association with SpA) | |||
** HLA-B*2709 (AS sparing) | |||
* ERAP1 | |||
* IL23R | |||
* TNFRSF1A | |||
* TRADD | |||
* TNFSF15 | |||
* IL1A | |||
* IL1R2 | |||
* CARD9 | |||
* ANTXR2 | |||
Revision as of 09:31, 29 August 2018
Spondyloarthropathy risk factors
Since the role of genetic in the presence of spondyloarthropathies have been known since several years ago, genetically predisposing individuals are who have HLA-B27 gene, are at risk of developing spondyloarthropathies.
The risk of developing spondyloarthropathies in individuals with HLA-B27 gene is 1-2%, however, it can increase to 15-20% if he/she have a first-degree relative with positive HLA-B27 gene and developed spondyloarthropathy.
There some genes that are suspicious for their association in SpA, which are included:
- HLA-B27
- HLA-B*2702 (Association with AS)
- HLA-B*2704 (Association with SpA)
- HLA-B*2705 (Strong association with AS)
- HLA-B*2706 (Very weak association with SpA)
- HLA-B*2709 (AS sparing)
- ERAP1
- IL23R
- TNFRSF1A
- TRADD
- TNFSF15
- IL1A
- IL1R2
- CARD9
- ANTXR2