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| == Differential Diagnosis ==
| | __NOTOC__ |
| Different causes of the bleeding disorders can be differentiated based on their clinical manifestation and laboratory findings.
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|
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| These features have discussed in the below table:
| | [[Sandbox: wdx]] |
| {| | | |
| ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Category
| | [[Xyz]] |
| ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Subcategory
| | |
| ! colspan="2" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Disease
| | [[Abc]] |
| ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |History
| | # [[Sandbox:Preeti]] |
| ! colspan="6" align="center" style="background:#4479BA; color: #FFFFFF;" + |Clinical manifestation
| | # [[Lymphoma]] |
| ! colspan="5" align="center" style="background:#4479BA; color: #FFFFFF;" + |Laboratory testing
| | # [[Breast lumps differential diagnosis]] |
| ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Comments
| | # [[Neck masses differential diagnosis]] |
| | # [[Leukemia]] |
| | {| class="wikitable" |
| | |+ |
| | |- |
| | | colspan="2" |[[:Category:Risk calculator]] |
| | [[Category:Risk calculator]] |
| | |- |
| | | colspan="2" |[[Deep vein thrombosis assessment of clinical probability and risk scores]] |
| | |- |
| | | colspan="2" |[[Pulmonary embolism assessment of clinical probability and risk scores]] |
| | |- |
| | |[[Padua prediction score]] |
| | |[[widget:PaduaVTEscore]] |
| | |- |
| | |[[IMPROVE risk score calculator]] |
| | |[[Widget:IMPROVEScore]] |
| | |- |
| | |[[IMPROVEDD risk score calculator]] |
| | |[[Widget:IMPROVEDDScore]] |
| | |- |
| | |[[Caprini score calculator]] |
| | |[[Widget:CapCal]] |
| | |- |
| | |[[Wells score calculator for DVT]] |
| | |[[Widget:DVT Wells score calculator]] |
| | |- |
| | |[[Modified Wells score calculator for DVT]] |
| | |[[Widget:DVT Modified Wells score calculator]] |
| | |- |
| | |[[Pulmonary embolism Wells score calculator]] |
| | |[[widget:PE_calculator]] |
| | |- |
| | |[[Pulmonary embolism modified Wells score calculator]] |
| | |[[Widget:PE Modified Wells score calculator]] |
| | |- |
| | |[[AMUSE score calculator]] |
| | |[[Widget:AMUSE_score_calculator]] |
| | |- |
| | |[[HAMILTON score calculator]] |
| | |[[Widget:HAMILTON_score_calculator]] |
| |- | | |- |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Mucosal bleeding
| | |[[Geneva score calculator]] |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Petechia
| | |[[Widget:Geneva_score_calculator]] |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Ecchymoses
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Menorrhagia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hematoma
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hemarthrosis
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Plt
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |BT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PTT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |TT
| |
| |- | | |- |
| ! rowspan="16" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Platelet disorders
| | |[[Revised Geneva score calculator]] |
| ! rowspan="7" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Thrombocytopenia]]
| | |[[Widget:Revised_Geneva_score_calculator]] |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Infection]]-Induced [[thrombocytopenia]]<span name="harr_c115s002s001s002p001"></span><span name="9100754"></span>
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * History of prior infection
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| |- | | |- |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Medication|Medications]]-Induced [[Thrombocytopenia|thrombocy]]<span name="harr_c115s002s001s003p001"></span><span name="9100757"></span>[[Thrombocytopenia|topenia]]
| | |[[Simplified Geneva Score calculator]] |
| | align="left" style="background:#F5F5F5;" | | | |[[Widget:Simplified_Geneva_score_calculator]] |
| *History of [[Medication|medications]] such as:
| |
| ** [[Furosemide]]
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| ** [[Non-steroidal anti-inflammatory drug|Nonsteroidal anti-inflammatory drugs]] ([[Non-steroidal anti-inflammatory drug|NSAIDs]])
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| ** [[Penicillin]]
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| ** [[Quinidine]]
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| ** [[Quinine]]
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| ** [[Ranitidine]]
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| ** [[Sulfonamide (medicine)|Sulfonamides]]
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| ** [[Linezolid]]
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Most important part of treatment is discontinuing of the medication.
| |
| |- | | |- |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Heparin-Induced Thrombocytopenia|Heparin-Induced thrombocytopenia]]<span name="harr_c115s002s001s004p001"></span><span name="9100761"></span>
| | |[[TIMI Risk Score for Unstable Angina or NSTEMI]] |
| | align="left" style="background:#F5F5F5;" | | | |[[Widget:TIMI_UA_NSTEMI]] |
| * [[Thrombosis]]
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| * Unexplained [[thrombocytopenia]] up to 3 weeks after the end of [[heparin]] therapy
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | For more information click here: [[Heparin-induced thrombocytopenia]].
| |
| |- | | |- |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Idiopathic thrombocytopenic purpura|Immune Thrombocytopenic Purpura]] ([[Idiopathic thrombocytopenic purpura|ITP]])<span name="harr_c115s002s001s005p001"></span><span name="9100771"></span>
| | |[[TIMI Risk Score for STEMI]] |
| | align="left" style="background:#F5F5F5;" | | | |[[Widget:TIMI_STEMI]] |
| * History of prior [[infection]] or no history
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| |- | | |- |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |Inherited [[Thrombocytopenia]]<span name="harr_c115s002s001s006p001"></span><span name="9100783"></span>
| | |[[Tygerberg score]] |
| | align="left" style="background:#F5F5F5;" | | | |[[widget:Tygerberg_score]] |
| * Positive family history
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| |- | | |- |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Thrombotic thrombocytopenic purpura|Thrombotic Thrombocytopenic Purpura]] ([[Thrombotic thrombocytopenic purpura|TTP]])<span name="harr_c115s002s002s001p001"></span><span name="9100787"></span>
| | |[[CHA2DS2-VASc Score]] |
| | align="left" style="background:#F5F5F5;" | History of: | | |[[Widget:CHA2DS2VASc]] |
| *[[Cancer]]
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| *[[Bone marrow transplantation]]
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| *[[Pregnancy]]
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| *[[Medication]]
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| **[[Platelet]] aggregation inhibitors ([[ticlopidine]] and [[clopidogrel]])
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| **Immunosuppressants ([[cyclosporine]], [[mitomycin]], [[tacrolimus]]/FK506, [[interferon|interferon-α]])
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| *[[HIV-1]] infection
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| |- | | |- |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Hemolytic-uremic syndrome|Hemolytic Uremic Syndrome]]<span name="harr_c115s002s002s002p001"></span><span name="9100796"></span>
| | |[[CHADS2 score]] |
| | align="left" style="background:#F5F5F5;" |History of: | | |[[Widget:CHADS2score]] |
| * [[Infections]]
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| * [[Malignancy]], [[chemotherapy]], and [[ionizing radiation]]
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| * [[Calcineurin inhibitor]]s and [[transplantation]]
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| * [[Pregnancy]], [[HELLP syndrome]], and [[oral contraceptive pill]]
| |
| * [[Systemic lupus erythematosis]]
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| * [[Antiphospholipid syndrome|Antiphospholipid antibody syndrome]]
| |
| * [[Glomerulopathy]]
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| |- | | |- |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Subcategory
| | |[[HAS-BLED score]] |
| ! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Disease
| | |[[Widget:HASBLEDscore]] |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |History
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Mucosal bleeding
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Petechia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Ecchymoses
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Menorrhagia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hematoma
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hemarthrosis
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Plt
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |BT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PTT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |TT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Comments
| |
| |- | | |- |
| ! align="center" style="padding: 5px 5px; background: #DCDCDC;" |Thromobcytosis
| | |[[The GRACE risk score]] |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Iron deficiency anemia|Iron deficiency anemia]]
| | |[[Widget:GRACEscore]] |
| Inflammatory diseases
| | |- |
| | | | |
| [[Splenectomy]] | | | |
| | | |- |
| [[Essential thrombocytosis|Essential thrombocytosis]]
| | |[[Ranson criteria]] |
| | align="left" style="background:#F5F5F5;" | | | [[Acute pancreatitis diagnostic criteria]] |
| * Digital [[pain]]
| | |[[Widget:RansonScore]] |
| * [[Gangrene]]
| | |- |
| * [[Erythromelalgia]]
| | |[[Apgar score]] |
| * H[[eadache]]
| | |[[Widget:Apgarscore]] |
| * [[Paresthesia|Paresthesias]]
| |
| * [[Transient ischemic attack|Transient ischemic attacks]]
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl or ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| |- | | |- |
| ! rowspan="6" align="center" style="padding: 5px 5px; background: #DCDCDC;" |Qualitative Disorders of [[Platelet]] Function<span name="harr_c115s002s004s001p001"></span><span name="9100803"></span>
| | |[[Glasgow coma scale]] |
| ! rowspan="4" align="center" style="padding: 5px 5px; background: #DCDCDC;" |Inherited Disorders of [[Platelet]] Function<span name="harr_c115s002s004s001p001"></span><span name="9100803"></span>
| | |[[Widget:Adult_GCS]] |
| ! align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Glanzmann's thrombasthenia|Glanzmann’s thrombasthenia]]
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Positive family history
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | Rare
| |
| | align="center" style="background:#F5F5F5;" | Nl or ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * AR inheritance
| |
| * Absence of the platelet Gp IIb/IIIa receptor
| |
| * Diminished for GP 2B-3A on [[Flow cytometry|flow cytometry]]
| |
| |- | | |- |
| ! align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Bernard-Soulier syndrome]]
| | |[[Pediatric Glasgow Coma Scale]] |
| | align="left" style="background:#F5F5F5;" | | | |[[Widget:PGCS]] |
| * Positive family history
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | Nl or ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * AR inheritance
| |
| * Absence of the platelet Gp Ib-IX-V receptor
| |
| * On PBS: giant platelets
| |
| * Ristocetin - no aggregation
| |
| |- | | |- |
| ! align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Wiskott-Aldrich syndrome]]
| | |[[Cincinnati stroke scale]] |
| | align="left" style="background:#F5F5F5;" | | | |[[Widget:Cincinnati_Stroke_Scale]] |
| * Positive family history
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | Nl or ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Anti-WASP antibody can be used to detect presence or absence of WAS protein
| |
| * In Wiskott–Aldrich syndrome, the [[Platelet|platelets]] are small and do not function properly. They are removed by the [[spleen]], which leads to low [[platelet]] counts.
| |
| |- | | |- |
| ! align="left" style="padding: 5px 5px; background: #DCDCDC;" |Platelet storage pool disorder:
| | |[[DIPSS Plus Score]] |
| *[[Hermansky-Pudlak syndrome]]
| | |[[Widget:DIPSS_Plus_Score]] |
| *[[Chediak-Higashi syndrome]]
| |
| *[[Gray platelet syndrome]]
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Positive family history
| |
| * [[Hairy cell leukemia]]
| |
| * [[Cardiovascular bypass]]
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | Nl or ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * AD inheritance
| |
| * AbNlities of platelet granule formation
| |
| |- | | |- |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |Acquired Disorders of [[Platelet]] Function<span name="harr_c115s002s004s002p001"></span><span name="9100808"></span>
| | | colspan="2" |[[ICU scoring systems]] |
| | align="left" style="background:#F5F5F5 " |
| |
| * [[Chronic renal failure pathophysiology|Uremia]]
| |
| * [[Cardiopulmonary bypass]]
| |
| * Hematologic disorders such as: [[Myeloproliferative disease|myeloproliferative]] and [[Myelodysplastic syndrome|myelodysplastic syndromes]]
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" | Nl or ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| |- | | |- |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Von Willebrand disease|Von Willebrand Disease]]<span name="harr_c115s002s005p001"></span><span name="9100810"></span>
| | |[[APACHE II]] |
| | align="left" style="background:#F5F5F5;" | | | |[[Widget:APACHEII]] |
| * Easy bruising
| |
| * [[Epistaxis]]
| |
| * Oral cavity bleeding
| |
| * Bleeding after dental extraction/surgery
| |
| * [[Menorrhagia]]
| |
| * [[Postpartum hemorrhage]]
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | See the table below for the details about different types.
| |
| |- | | |- |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Subcategory
| | |[[SAPS II]] |
| ! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Disease
| | |[[Widget:SAPSII]] |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |History
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Mucosal bleeding
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Petechia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Ecchymoses
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Menorrhagia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hematoma
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hemarthrosis
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Plt
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |BT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PTT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |TT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Comments
| |
| |- | | |- |
| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Vessel wall disorders
| | |[[SAPS III]] |
| ! align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Metabolism|Metabolic]] and [[Inflammation|Inflammatory]] Disorders
| | |[[Widget:SAPSIII]] |
| ! colspan="2" align="left" style="padding: 5px 5px; background: #DCDCDC;" |
| |
| * Acute febrile illnesses
| |
| * [[Cryoglobulinemia|Mixed cryoglobulinemia]]
| |
| * [[Monoclonal gammopathy|Monoclonal gammopathies]]
| |
| * [[Rocky Mountain spotted fever]]
| |
| * [[Vitamin C deficiency]]
| |
| * [[Cushing's syndrome|Cushing’s syndrome]]
| |
| * Chronic [[glucocorticoid]] therapy
| |
| * [[Vasculitis]] such as Henoch-Schönlein Purpura
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * History of the underlying disease
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl or ↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| |- | | |- |
| ! align="center" style="padding: 5px 5px; background: #DCDCDC;" |Inherited Disorders of the [[Vessel wall|Vessel Wall]]
| | |[[PIM2]] |
| ! colspan="2" align="left" style="background:#DCDCDC;" |
| | | |
| * [[Marfan's syndrome|Marfan’s syndrome]]
| | |} |
| * [[Ehlers-Danlos syndrome]]
| | ==Table== |
| * [[Pseudoxanthoma elasticum]]
| | {| |
| * [[Hereditary hemorrhagic telangiectasia]] ([[Hereditary hemorrhagic telangiectasia|HHT]], or [[Osler-Weber-Rendu|Osler-Weber-Rendu disease]])
| | ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Complications |
| | align="left" style="background:#F5F5F5;" |
| | ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Polymyositis |
| * Positive family history
| | ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Dermatomyositis |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |± | |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl or ↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| |- | | |- |
| ! rowspan="15" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Coagulation factor disorders
| | ! align="center" style="background:#DCDCDC;" + |[[Cancer|Malignancy]] |
| <ref name="pmid28966616" />
| | | align="left" style="background:#F5F5F5;" + | |
| ! align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Fibrinogen]] deficiency | | *[[Lung]] |
| ! colspan="2" align="left" style="padding: 5px 5px; background: #DCDCDC;" |
| | | align="left" style="background:#F5F5F5;" + | |
| Different types of the [[fibrinogen]] disorders:
| | *[[Lung]] |
| * [[Fibrinogen#Congenital afibrinogenemia|Congenital afibrinogenemia]]
| | |} |
| * [[Fibrinogen#Congenital hypofibrinogenemia|Congenital hypofibrinogenemia]]
| | <br> |
| * [[Fibrinogen#Fibrinogen storage disease|Fibrinogen storage disease]]
| | ===Calculation of the Padua Prediction Score=== |
| * [[Fibrinogen#Congenital dysfibrinogenemia|Congenital dysfibrinogenemia]]
| | Shown below is a calculator using the predictive score for VTE among hospitalized medical patients. Check all boxes that apply to your patient: |
| * [[Fibrinogen#Hereditary fibrinogen A.CE.B1-Chain amyloidosis|Hereditary fibrinogen Aα-Chain amyloidosis]]
| | |
| * [[Fibrinogen#Acquired dysfibrinogenemia|Acquired dysfibrinogenemia]] | | {| style="border: 0; float: left; width: 45%; position: float; background: #104E8B; border-radius: 10px 10px 10px 10px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5); margin: 0 0 0 0; padding: 5px 5px; font-weight: bold;" |
| | align="left" style="background:#F5F5F5;" | | | | colspan="2" style="text-align: center; color: #FFFFFF; font-size: 120%;" | IMPROVE Bleeding Risk Score |
| * [[Epistaxis]] | |
| * Easy [[Bruise|bruising]]
| |
| * [[Menorrhagia]]
| |
| * [[Muscle]] bleeds
| |
| * [[Hemarthrosis]]
| |
| * [[Bleeding]] from the [[umbilical cord]] stump after birth
| |
| * Bleeding after [[dental surgery]] or tooth extraction
| |
| * AbNl bleeding during or after injury, surgery, or childbirth
| |
| * [[Gastrointestinal tract|Gastrointestinal]] [[hemorrhage]]
| |
| * [[Cerebral hemorrhage]]
| |
| * [[Thrombosis]]
| |
| | align="center" style="background:#F5F5F5;" |− | |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |↑ | |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Impaired fibrin cross-linking or clot dissolution
| |
| * Mild or severe bleeding idepend on levels of functional fibrinogen
| |
| * Variable age of onset
| |
| |- | | |- |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Subcategory | | ! style=" text-align: left; color: #4479BA; background: #FFFFFF; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Variable |
| ! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Disease
| | ! style=" text-align: center; color: #4479BA; background: #FFFFFF; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Score |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |History
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Mucosal bleeding
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Petechia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Ecchymoses
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Menorrhagia | |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hematoma
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hemarthrosis
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Plt
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |BT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PTT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |TT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Comments
| |
| |- | | |- |
| ! colspan="3" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Prothrombin deficiency]] | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Active gastric or duodenal ulcer |
| | align="left" style="background:#F5F5F5;" |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |4.5 |
| * [[Epistaxis]]
| |
| * Soft-tissue hemorrhage
| |
| * Excessive postoperative bleeding
| |
| * [[Menorrhagia]]
| |
| * Muscle [[Hematoma|hematomas]]
| |
| * [[Hemarthrosis]]
| |
| * [[Intracranial hemorrhage|Intracranial]] bleeding
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | + | |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| |- | | |- |
| ! colspan="3" rowspan="1" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Factor V deficiency]] | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Prior bleeding within the last 3 months |
| | align="left" style="background:#F5F5F5;" |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |4 |
| * Excessive bruising with minor injuries
| |
| * [[Epistaxis]]
| |
| * [[Hemarthrosis]]
| |
| * [[Menorrhagia]]
| |
| * [[Intracerebral hemorrhage|Intracerebral hemorrhages]]
| |
| * [[Pulmonary hemorrhage]]
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | + | |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |
| |
| * The severity of bleeding related to the degree of factor V deficiency
| |
| |- | | |- |
| ! colspan="3" rowspan="1" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Factor VII deficiency]] | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Thrombocytopenia (<50x10<sup>9</sup>/L) |
| | align="left" style="background:#F5F5F5;" |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |4 |
| * Easy [[Bruise|bruising]]
| |
| * Mucosal bleeding
| |
| * Postoperative bleeding
| |
| * [[Menorrhagia]]
| |
| * Soft tissue hematomas
| |
| * [[Thrombosis]]
| |
| | align="center" style="background:#F5F5F5;" |
| |
| | align="center" style="background:#F5F5F5;" |
| |
| | align="center" style="background:#F5F5F5;" |
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | + | |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Thrombosis in inherited factor VII deficiency
| |
| * Treatment with the administration of factor VII replacement therapy
| |
| |- | | |- |
| ! colspan="3" rowspan="1" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Factor X deficiency]] | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Age ≥ 85 years |
| | align="left" style="background:#F5F5F5;" |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |3.5 |
| * Prolonged bleeding following circumcision
| |
| * Easy [[Bruise|bruising]]
| |
| * [[Hematuria]]
| |
| * [[Menorrhagia]]
| |
| * Abortion
| |
| * Postpartum hemorrhage
| |
| * Epistaxis
| |
| * Pseudotumors
| |
| * Intracranial bleeding
| |
| * Hemarthroses
| |
| | align="center" style="background:#F5F5F5;" |
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | + | |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| |- | | |- |
| ! colspan="3" rowspan="1" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Factor XII|Factor XII deficiency]] | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Liver failure (INR>1.5) |
| | align="left" style="background:#F5F5F5;" |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |2.5 |
| * Asymptomatic
| |
| * Recurrent miscarriages
| |
| * Painful leg ulcers
| |
| | align="center" style="background:#F5F5F5;" |
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |− | |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |
| |
| |- | | |- |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Subcategory | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Severe kidney failure (GFR< 30 mL/min/m<sup>2</sup>) |
| ! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Disease
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |2.5 |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |History
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Mucosal bleeding
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Petechia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Ecchymoses
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Menorrhagia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hematoma
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hemarthrosis
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Plt
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |BT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PTT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |TT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Comments
| |
| |- | | |- |
| ! colspan="3" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[High-molecular-weight kininogen|High molecular weight kininogen (HMWK)]] deficiency | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Admission to ICU or CCU |
| | align="left" style="background:#F5F5F5;" |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |2.5 |
| * Positive family history of bleeding
| |
| | align="center" style="background:#F5F5F5;" |
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |− | |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |
| |
| |- | | |- |
| ! colspan="3" rowspan="1" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Prekallikrein]] deficiency | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Central venous catheter |
| | align="left" style="background:#F5F5F5;" |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |2 |
| * Positive family history of bleeding
| |
| | align="center" style="background:#F5F5F5;" |
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |− | |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |
| |
| |- | | |- |
| ! rowspan="1" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Factor XIII deficiency]] | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Rheumatic disease |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |2 |
| * Sub unit A mutation disease (more common)
| |
| * Sub unit B mutation disease
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Positive family history of bleeding
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" |± | |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl or ↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Impaired fibrin cross-linking or clot dissolution
| |
| * The severity of factor XIII deficiency bleeds can be different in different patients
| |
| |- | | |- |
| ! rowspan="3" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Hemophilia]] | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Active malignancy |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |Type A deficiency
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |2 |
| | align="left" style="background:#F5F5F5;" |
| |
| * Eeasy [[Bruise|bruising]]
| |
| * Inadequate clotting in [[trauma]] or mild injury
| |
| * Spontaneous hemorrhage
| |
| * [[Hemarthrosis]]
| |
| * [[Epistaxis]]
| |
| * [[Gingival bleeding]]
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |+ | |
| | align="center" style="background:#F5F5F5;" |+
| |
| | align="center" style="background:#F5F5F5;" |+
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| |- | | |- |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |Type B deficiency | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Age: 40-84 years |
| | align="left" style="background:#F5F5F5;" |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |1.5 |
| * Neonatal bleeding
| |
| * Trauma-related soft tissue hemorrhage
| |
| * [[Hemarthrosis]]
| |
| * [[Hematoma|Hematomas]]
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |+ | |
| | align="center" style="background:#F5F5F5;" |+
| |
| | align="center" style="background:#F5F5F5;" |+
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| |- | | |- |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |Type C deficiency | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Male |
| | align="left" style="background:#F5F5F5;" |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |1 |
| * Positive family history
| |
| * Bleeding after surgery or injury
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |+
| |
| | align="center" style="background:#F5F5F5;" |Rare | |
| | align="center" style="background:#F5F5F5;" |Rare
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| |- | | |- |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Subcategory | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Moderate kidney failure (GFR: 30-59 mL/min/m<sup>2</sup>) |
| ! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Disease
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |1 |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |History
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Mucosal bleeding
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Petechia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Ecchymoses
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Menorrhagia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hematoma
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hemarthrosis
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Plt
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |BT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PTT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |TT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Comments
| |
| |- | | |- |
| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Rare diseases | | ! colspan="2" style=" text-align: left; color: #4479BA; background: #FFFFFF; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Result: |
| ! colspan="3" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Disseminated intravascular coagulation|Disseminated Intravascular Coagulation]]
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * [[Trauma]]
| |
| * [[Burn]]
| |
| * [[Crush injury]]
| |
| * [[Sepsis]]
| |
| * [[Malignancy]]
| |
| * Obstetric complication: abruption, amniotic fluid embolism
| |
| * [[Hemolytic anemia]]
| |
| | align="center" style="background:#F5F5F5;" |+
| |
| | align="center" style="background:#F5F5F5;" |+
| |
| | align="center" style="background:#F5F5F5;" |+
| |
| | align="center" style="background:#F5F5F5;" |+
| |
| | align="center" style="background:#F5F5F5;" |+
| |
| | align="center" style="background:#F5F5F5;" |+
| |
| | align="center" style="background:#F5F5F5;" |↓
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| |- | | |- |
| ! colspan="3" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Vitamin K Deficiency]] | | ! colspan="2" style=" text-align: left; color: #4479BA; background: #FFFFFF; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Interpretation: |
| | align="left" style="background:#F5F5F5;" |
| |
| * Bleeding after trauma
| |
| * [[Epistaxis]]
| |
| * [[Hematoma]]
| |
| * Gastrointestinal bleeding
| |
| * [[Menorrhagia]]
| |
| * [[Hematuria]]
| |
| * Gum bleeding
| |
| * Oozing from venipuncture sites
| |
| * Easy [[Bruise|bruisability]]
| |
| | align="center" style="background:#F5F5F5;" |+
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |+
| |
| | align="center" style="background:#F5F5F5;" |+
| |
| | align="center" style="background:#F5F5F5;" |+
| |
| | align="center" style="background:#F5F5F5;" |+
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl or mildly prolonged
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| |} | | |} |
| | <br style="clear:left" /> |
| | |
| | ===Calculation of the test Prediction Score=== |
| | Shown below is a calculator using the predictive score for VTE among hospitalized medical patients. Check all boxes that apply to your patient: |
|
| |
|
| ==Different types of Von-Willebrand diseases== | | {| style="border: 0; float: left; width: 45%; position: float; background: #104E8B; border-radius: 10px 10px 10px 10px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5); margin: 0 0 0 0; padding: 5px 5px; font-weight: bold;" |
| {|
| | | colspan="2" style="text-align: center; color: #FFFFFF; font-size: 120%;" | IMPROVE Bleeding Risk Score |
| ! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Type of VWD | | |- |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Type of factor deficiency | | ! style=" text-align: left; color: #4479BA; background: #FFFFFF; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Variable |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Prevalence
| | ! style=" text-align: center; color: #4479BA; background: #FFFFFF; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Score |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Inheritance pattern | | |- |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Clinical manifestations
| | ! rowspan="2" style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Gender |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |VWF activity | | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Female |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |RIPA | | |- |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Factor VIII | | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Male |
| | |- |
| | ! rowspan="4" style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Age |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |0-70 |
| | |- |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |71-80 |
| | |- |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |81-90 |
| | |- |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |>90 |
| | |- |
| | ! rowspan="5" style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Hgb ('''g/dL)''' |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |>17 '''g/dL''' |
| | |- |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |15.5-17 '''g/dL''' |
| | |- |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |12.5-15.5 '''g/dL''' |
| | |- |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |12.5-11 '''g/dL''' |
| | |- |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |<11 '''g/dL''' |
| | |- |
| | ! rowspan="2" style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |CrCl (mL/min) |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |30-60 mL/min |
| | |- |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |15-30 mL/min |
| | |- |
| | ! rowspan="2" style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Albumin |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |>3.5 g/dL |
| | |- |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |≤3.5 g/dL |
| | |- |
| | ! rowspan="2" style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |D-dimer |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |≥1 µg/mL |
| |- | | |- |
| ! colspan="2" align="center" style="background:#DCDCDC;" |Type 1
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |<1 µg/mL |
| | align="center" style="background:#F5F5F5;" | Quantitative/ partial
| |
| | align="center" style="background:#F5F5F5;" | 60-70%
| |
| | align="center" style="background:#F5F5F5;" | AD
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Bleeding severity mild to severe
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| |- | | |- |
| ! rowspan="4" align="center" style="background:#DCDCDC;" |Type 2 | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |ICU admission |
| ! align="center" style="background:#DCDCDC;" |2A
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" | |
| | align="center" style="background:#F5F5F5;" | Qualitative | |
| | align="center" style="background:#F5F5F5;" | 10%
| |
| | align="center" style="background:#F5F5F5;" | AD/AR
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Moderate to severe [[bleeding]]
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | N or ↓
| |
| |- | | |- |
| ! align="center" style="background:#DCDCDC;" |2B | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Acute stroke on hospitalization |
| | align="center" style="background:#F5F5F5;" | Qualitative
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" | |
| | align="center" style="background:#F5F5F5;" | 5%
| |
| | align="center" style="background:#F5F5F5;" | AD
| |
| | align="left" style="background:#F5F5F5;" | | |
| * [[Thrombocytopenia]]
| |
| * Moderate to severe [[bleeding]]
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | N or ↓
| |
| |- | | |- |
| ! align="center" style="background:#DCDCDC;" |2M | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |History of VTE |
| | align="center" style="background:#F5F5F5;" | Qualitative
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" | |
| | align="center" style="background:#F5F5F5;" | <1% | |
| | align="center" style="background:#F5F5F5;" | AD/AR
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Moderate to severe [[bleeding]]
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | N or ↓
| |
| |- | | |- |
| ! align="center" style="background:#DCDCDC;" |2N | | ! colspan="2" style=" text-align: left; color: #4479BA; background: #FFFFFF; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Result: |
| | align="center" style="background:#F5F5F5;" | Qualitative
| |
| | align="center" style="background:#F5F5F5;" | <1%
| |
| | align="center" style="background:#F5F5F5;" | AR
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Clinically similar to [[hemophilia A]] with [[joint]], [[soft tissue]], [[urinary]] [[bleeding]]
| |
| | align="center" style="background:#F5F5F5;" | N
| |
| | align="center" style="background:#F5F5F5;" | N
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| |- | | |- |
| ! colspan="2" align="center" style="background:#DCDCDC;" |Type 3 | | ! colspan="2" style=" text-align: left; color: #4479BA; background: #FFFFFF; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Interpretation: |
| | align="center" style="background:#F5F5F5;" | Complete deficiency
| |
| | align="center" style="background:#F5F5F5;" | 1-2%
| |
| | align="center" style="background:#F5F5F5;" | AR
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Clinically similar to [[hemophilia A]] with [[joint]] and [[soft tissue]] [[bleeding]]
| |
| * Severe [[mucosal bleeding]]
| |
| | align="center" style="background:#F5F5F5;" | Absent
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | Low, 1-10%
| |
| |} | | |} |
| For more information on Von Willebrand disease, click [[ von willebrand disease | here]].
| | <br style="clear:left" /> |
| | |
| | ===Interpretation of the Padua Prediction Score=== |
| | The interpretation of the score is as follows: |
| | * Score ≥ 4: High risk for VTE |
| | * Score < 4: Low risk for VTE |
| | ==References== |
| <references /> | | <references /> |