Rh disease medical therapy

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Rh disease Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Medical Therapy

Antenatal

  • Ultrasound - to detect and monitor hydrops fetalis
  • Quantitative analysis of maternal anti-RhD antibodies - an increasing level is a sign of fetal Rh disease[1]
  • Intrauterine blood transfusion
    • Intraperitoneal transfusion - blood transfused into fetal abdomen
    • Intravascular transfusion - blood transfused into fetal umbilical vein - This is more modern and more effective than intraperitoneal transfusion. A sample of fetal blood can be taken from the umbilical vein prior to the transfusion.
  • Early delivery (usually after about 36 wks gestation)

Postnatal

  • Phototherapy for neonatal jaundice in mild disease
  • Exchange transfusion if the neonate has moderate or severe disease (the blood for transfusion must be less than a week old, Rh negative, ABO compatible with both the fetus and the mother, and be cross matched against the mothers serum)

References

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