Retinoblastoma risk factors: Difference between revisions
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===Advanced paternal age=== | ===Advanced paternal age=== | ||
There is evidence suggesting that the mutations of RB1 are more common during spermatogenesis than oogenesis. | There is evidence suggesting that the mutations of RB1 are more common during spermatogenesis than oogenesis.<ref name="DryjaMukai1989">{{cite journal|last1=Dryja|first1=Thaddeus P.|last2=Mukai|first2=Shizuo|last3=Petersen|first3=Robert|last4=Rapaport|first4=Joyce M.|last5=Walton|first5=David|last6=Yandell|first6=David W.|title=Parental origin of mutations of the retinoblastoma gene|journal=Nature|volume=339|issue=6225|year=1989|pages=556–558|issn=0028-0836|doi=10.1038/339556a0}}</ref> | ||
==See also== | ==See also== |
Revision as of 16:39, 11 October 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
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Overview
Common risk factors in the development of retinoblastoma are, advanced paternal age, positive family history, and viral exposure.
Common Risk Factors
Family History
Approximately 10% of patients with retinoblastoma have a previously established family history of the disease.
Viral exposure
The presence of HPV sequences in retinoblastoma tumor tissue may play a role in the development of sporadic retinoblastoma.
Advanced paternal age
There is evidence suggesting that the mutations of RB1 are more common during spermatogenesis than oogenesis.[1]
See also
References
- ↑ Dryja, Thaddeus P.; Mukai, Shizuo; Petersen, Robert; Rapaport, Joyce M.; Walton, David; Yandell, David W. (1989). "Parental origin of mutations of the retinoblastoma gene". Nature. 339 (6225): 556–558. doi:10.1038/339556a0. ISSN 0028-0836.