Retinoblastoma epidemiology and demographics: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
|||
| Line 7: | Line 7: | ||
Here are some highlights listed by the SEER (Surveillance, Epidemiology and End Results) about the incidence of retinoblastoma among children and adolescents.<ref> http://seer.cancer.gov/publications/childhood/retinoblastoma.pdf </ref> | Here are some highlights listed by the SEER (Surveillance, Epidemiology and End Results) about the incidence of retinoblastoma among children and adolescents.<ref> http://seer.cancer.gov/publications/childhood/retinoblastoma.pdf </ref> | ||
*Retinoblastoma accounted for approximately 11% of cancers developing in the first year of life,but for only 3% of the cancers developing among children younger than 15 years of age. | * Retinoblastoma accounted for approximately 11% of cancers developing in the first year of life,but for only 3% of the cancers developing among children younger than 15 years of age. | ||
*In the US, approximately 300 children and adolescents younger than 20 years of age are diagnosed with retinoblastomas each year. | * In the US, approximately 300 children and adolescents younger than 20 years of age are diagnosed with retinoblastomas each year. | ||
*The vast majority of cases of retinoblastoma occur among young children with almost two-thirds(63%) of retinoblastomas occuring before the age of two years and 95% occuring before the age of 5 years. | * The vast majority of cases of retinoblastoma occur among young children with almost two-thirds(63%) of retinoblastomas occuring before the age of two years and 95% occuring before the age of 5 years. | ||
*The incidence of bilateral tumors was strongly age dependent with 42% of the retinoblastomas occuring in children less than one year of age being bilateral compared to 21% of those among children aged one year, and only 9% among older children. | * The incidence of bilateral tumors was strongly age dependent with 42% of the retinoblastomas occuring in children less than one year of age being bilateral compared to 21% of those among children aged one year, and only 9% among older children. | ||
*Rates of retinoblastoma were the same among males (3.7 per million) and females (4.0 per million) and also among whites (3.7 per million) and blacks (4.0 per million). | * Rates of retinoblastoma were the same among males (3.7 per million) and females (4.0 per million) and also among whites (3.7 per million) and blacks (4.0 per million). | ||
*There was no subsantial change in the retinoblastoma incidence during the 21 year period, 1975-95. | * There was no subsantial change in the retinoblastoma incidence during the 21 year period, 1975-95. | ||
*It is estimated that 38.2% of patients with hereditary retinoblastoma will develop a secondary malignancy with an associated long-term mortality rate of 26%. | * It is estimated that 38.2% of patients with hereditary retinoblastoma will develop a secondary malignancy with an associated long-term mortality rate of 26%. | ||
* Retinoblastoma presents with cumulative lifetime incidence rate of 1 case of retinoblastoma per 18000 to 30000 live births worldwide. A higher incidence is noted in developing countries, this has been implicated to lower socioeconomic status and the presence of human papilloma virus sequences in the retinoblastoma tissue. | |||
* Almost 80% of children with retinoblastoma are diagnosed before 3 years of age and diagnosis in children above 6 years of age is extremely rare. In the UK, bilateral cases usually present within 14–16 months, while diagnosis of unilateral cases peaks between 24 and 30 months. | |||
==References== | ==References== | ||
Revision as of 18:23, 4 September 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
|
Retinoblastoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Retinoblastoma epidemiology and demographics On the Web |
|
American Roentgen Ray Society Images of Retinoblastoma epidemiology and demographics |
|
Risk calculators and risk factors for Retinoblastoma epidemiology and demographics |
Overview
Incidence and Prevalence
Here are some highlights listed by the SEER (Surveillance, Epidemiology and End Results) about the incidence of retinoblastoma among children and adolescents.[1]
- Retinoblastoma accounted for approximately 11% of cancers developing in the first year of life,but for only 3% of the cancers developing among children younger than 15 years of age.
- In the US, approximately 300 children and adolescents younger than 20 years of age are diagnosed with retinoblastomas each year.
- The vast majority of cases of retinoblastoma occur among young children with almost two-thirds(63%) of retinoblastomas occuring before the age of two years and 95% occuring before the age of 5 years.
- The incidence of bilateral tumors was strongly age dependent with 42% of the retinoblastomas occuring in children less than one year of age being bilateral compared to 21% of those among children aged one year, and only 9% among older children.
- Rates of retinoblastoma were the same among males (3.7 per million) and females (4.0 per million) and also among whites (3.7 per million) and blacks (4.0 per million).
- There was no subsantial change in the retinoblastoma incidence during the 21 year period, 1975-95.
- It is estimated that 38.2% of patients with hereditary retinoblastoma will develop a secondary malignancy with an associated long-term mortality rate of 26%.
- Retinoblastoma presents with cumulative lifetime incidence rate of 1 case of retinoblastoma per 18000 to 30000 live births worldwide. A higher incidence is noted in developing countries, this has been implicated to lower socioeconomic status and the presence of human papilloma virus sequences in the retinoblastoma tissue.
- Almost 80% of children with retinoblastoma are diagnosed before 3 years of age and diagnosis in children above 6 years of age is extremely rare. In the UK, bilateral cases usually present within 14–16 months, while diagnosis of unilateral cases peaks between 24 and 30 months.