Primary effusion lymphoma: Difference between revisions

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{{SI}}
{{Primary effusion lymphoma}}
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{{CMG}}


{{SK}} Body cavity lymphoma
{{SK}} Body cavity lymphoma


==Overview==
==[[Primary effusion lymphoma overview|Overview]]==


'''Primary effusion lymphoma''' (PEL) is a malignancy of B cells that is caused by [[Kaposi's sarcoma-associated herpesvirus]] (KSHV), also known as human herpesvirus 8 (HHV-8)<ref>Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 1995;332(18):1186-91.</ref>. In about 80% of cases, the lymphoma cells are also infected with [[Epstein Barr virus]] (EBV).  PEL is unusual in that the majority of cases arise in body cavities, such as the pleural space or the pericardium<ref>Staudt MR, Kanan Y, Jeong JH, Papin JF, Hines-Boykin R, Dittmer DP. The tumor microenvironment controls primary effusion lymphoma growth in vivo. Cancer Res 2004;64(14):4790-9.</ref>.
==[[Primary effusion lymphoma historical perspective|Historical Perspective]]==


==Historical Perspective==
==[[Primary effusion lymphoma pathophysiology|Pathophysiology]]==
Primary effusion lymphoma was recognized as a unique type of lymphoma only after the discovery of KSHV in 1994.


==Causes==
==[[Primary effusion lymphoma causes|Causes]]==
PEL most commonly arises in patients with underlying immunodeficiency, such as [[AIDS]]<ref>Boshoff C, Weiss R. AIDS-related malignancies. Nat Rev Cancer 2002;2(5):373-82.</ref>. It is caused by [[Kaposi's sarcoma-associated herpesvirus]] (KSHV).


==Prognosis==
==[[Primary effusion lymphoma differential diagnosis|Differentiating Primary effusion lymphoma from other Diseases]]==
PEL carries a very poor prognosis.
 
==[[Primary effusion lymphoma epidemiology and demographics|Epidemiology and Demographics]]==
 
==[[Primary effusion lymphoma risk factors|Risk Factors]]==
 
==[[Primary effusion lymphoma natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
 
==Diagnosis==
 
[[Primary effusion lymphoma staging|Staging]] | [[Primary effusion lymphoma history and symptoms|History and Symptoms]] | [[Primary effusion lymphoma physical examination|Physical Examination]] | [[Primary effusion lymphoma laboratory findings|Laboratory Findings]] | [[Primary effusion lymphoma electrocardiogram|EKG]] | [[Primary effusion lymphoma chest x ray|Chest X ray]] | [[Primary effusion lymphoma CT|CT]] | [[Primary effusion lymphoma MRI|MRI]] | [[Primary effusion lymphoma echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Primary effusion lymphoma other imaging findings|Other Imaging Findings]] | [[Primary effusion lymphoma other diagnostic studies|Other Diagnostic Studies]]


==Treatment==
==Treatment==
Primary effusion lymphoma is generally resistant to cancer [[chemotherapy]] drugs that are active against other [[lymphomas]] <ref>Yarchoan R, Tosato G, Little RF. Therapy insight: AIDS-related malignancies - the influence of antiviral therapy on pathogenesis and management. Nature Clin Prac Oncology 2005;2(8):406-15.</ref>.


==References==
[[Primary effusion lymphoma medical therapy|Medical Therapy]]  | [[Primary effusion lymphoma primary prevention|Primary Prevention]] | [[Primary effusion lymphoma secondary prevention|Secondary Prevention]] | [[Primary effusion lymphoma cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Primary effusion lymphoma future or investigational therapies|Future or Investigational Therapies]]
{{Reflist|2}}
 
==Case Studies==
[[Primary effusion lymphoma case study one|Case #1]]
 
 
 
 


{{Hematological malignancy histology}}
{{Hematological malignancy histology}}

Revision as of 15:45, 21 September 2012

Primary effusion lymphoma
ICD-O: 9678/3
DiseasesDB 33904

Template:Primary effusion lymphoma Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Body cavity lymphoma

Overview

Historical Perspective

Pathophysiology

Causes

Differentiating Primary effusion lymphoma from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

Staging | History and Symptoms | Physical Examination | Laboratory Findings | EKG | Chest X ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1




Template:WikiDoc Sources

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