Non-alcoholic fatty liver disease epidemiology and demographics
|
Non-Alcoholic Fatty Liver Disease Microchapters |
|
Differentiating Non-Alcoholic Fatty Liver Disease from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case studies |
|
Non-alcoholic fatty liver disease epidemiology and demographics On the Web |
|
American Roentgen Ray Society Images of Non-alcoholic fatty liver disease epidemiology and demographics |
|
FDA on Non-alcoholic fatty liver disease epidemiology and demographics |
|
CDC on Non-alcoholic fatty liver disease epidemiology and demographics |
|
Non-alcoholic fatty liver disease epidemiology and demographics in the news |
|
Blogs on Non-alcoholic fatty liver disease epidemiology and demographics |
|
Directions to Hospitals Treating Non-alcoholic fatty liver disease |
Editor in Chief: Elliot Tapper, M.D., Beth Israel Deaconess Medical Center, C. Michael Gibson, M.S., M.D. [1]
Overview
Estimates are that between 30 - 90 million Americans have some degree of NAFLD and 5-6% have NASH. [1]In the third National Health and Nutrition Examination Survey (NHANES III), the peak prevalence of NAFLD in men occurred in the fourth decade and in the sixth decade for women.[2][3]
Epidemiology and Demographics
Prevalance
A Japanese study estimates the prevalence of NAFLD in that country at 3,100 per 100,000 and found an incidence of approximately 10% - 308 new cases of NAFLD in a group of 3,147 patients followed over 414 days.[4] Some have suggested a genetic or sociocultural component to NAFLD spectrum disease.[5]
Ethinicity
As a part of the Dallas Heart Study,[6] 2,240 patients - 1,105 african-americans, 401 hispanics and 734 caucasians - received abdominal MRI's from which we can infer the presence of steatosis. Hepatic steatosis was found in 45% of hispanics (both men and women), 33% of caucasians (42% of men, 24% of women) and 24% of african-american (23% of men, 24% of women). This pattern may hold true in children as well. In a San Diego study of 742 consecutive autopsies of children victims of trauma over 10 years, fatty liver was found in 9.6% of all children, 38% of the obese, 12% of hispanics, 10% of asians, 8.6% of caucasians and 1.5% of african-americans.[7]
References
- ↑ McCullough, AJ. Thiazolidinediones for NASH. NEJM 2006;355(22):2361-2363.
- ↑ Ong JP et al. Epidemiology and Natural History of NAFLD and NASH. Clin Liver Dis 11 (2007) 1–16
- ↑ Ruhl CE, Everhart JE. Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the united states. Gastroenterology 2003;124(1):71–9.
- ↑ Hamaguchi M, Kojima T, Takeda N, et al. The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann Intern Med 2005;143(10):722–8
- ↑ Caldwell et al. Has natural selection in human populations produced two types of metabolic syndrome (with and without fatty liver). J of Gastroenterology and Hepatology 2007;22(S1):S11-S19
- ↑ Browning et al. Prevalence of Hepatic Steatosis in an Urban Population in the United States: Impact of Ethnicity. Hepatology 2004;40:1387-1395.
- ↑ Schwimmer et al. Prevalence of fatty liver in children and adolescents. Pediatrics 2006;118;1388-93.