Nasopharyngeal carcinoma natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
==Prognosis== | ==Prognosis== | ||
The five-year survival rate of nonkeratinizing and undifferentiated nasopharyngeal carcinomas, with appropriate treatment, is about 65% overall. Cure is highly possible, even when disease has spread to the regional lymph nodes. The prognosis of keratinizing NPC is significantly worse, due to its greater resistance to radiation.<ref name="Weidner's">{{cite book |author=Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor) |title=Modern Surgical Pathology (2 Volume Set) |publisher=W B Saunders |location=London |year= |pages= |isbn=0-7216-7253-1 |oclc= |doi=}}</ref> | The five-year survival rate of [[nonkeratinizing]] and undifferentiated nasopharyngeal carcinomas, with appropriate treatment, is about 65% overall. Cure is highly possible, even when disease has spread to the regional [[lymph]] nodes. The prognosis of keratinizing NPC is significantly worse, due to its greater resistance to radiation.<ref name="Weidner's">{{cite book |author=Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor) |title=Modern Surgical Pathology (2 Volume Set) |publisher=W B Saunders |location=London |year= |pages= |isbn=0-7216-7253-1 |oclc= |doi=}}</ref> | ||
Prognosis is influenced both by stage and tumour type. | Prognosis is influenced both by stage and tumour type. | ||
*type I: keratinizing [[squamous]] cell carcinoma - 42% 5-year survival | |||
*type I: keratinizing squamous cell carcinoma - 42% 5-year survival | *type II: non-keratinizing squamous cell [[carcinoma]] - 65% 5-year survival | ||
*type II: non-keratinizing squamous cell carcinoma - 65% 5-year survival | |||
*type III: undifferentiated carcinoma - 14% 5-year survival<ref>http://radiopaedia.org/articles/nasopharyngeal-carcinoma</ref> | *type III: undifferentiated carcinoma - 14% 5-year survival<ref>http://radiopaedia.org/articles/nasopharyngeal-carcinoma</ref> | ||
Revision as of 20:32, 8 September 2015
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Differentiating Nasopharyngeal carcinoma from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Prognosis
The five-year survival rate of nonkeratinizing and undifferentiated nasopharyngeal carcinomas, with appropriate treatment, is about 65% overall. Cure is highly possible, even when disease has spread to the regional lymph nodes. The prognosis of keratinizing NPC is significantly worse, due to its greater resistance to radiation.[1]
Prognosis is influenced both by stage and tumour type.
- type I: keratinizing squamous cell carcinoma - 42% 5-year survival
- type II: non-keratinizing squamous cell carcinoma - 65% 5-year survival
- type III: undifferentiated carcinoma - 14% 5-year survival[2]
Complications
- Airway obstruction
- Difficulty swallowing
- Disfigurement of the neck or face
- Hardening of the skin of the neck
- Loss of voice and speaking ability
- Spread of the cancer to other body areas (metastasis)
References
- ↑ Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor). Modern Surgical Pathology (2 Volume Set). London: W B Saunders. ISBN 0-7216-7253-1.
- ↑ http://radiopaedia.org/articles/nasopharyngeal-carcinoma