Myeloproliferative neoplasm differential diagnosis: Difference between revisions
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* Transfusion support | * Transfusion support | ||
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Age-related changes in the bone marrow contribute to myelodysplastic syndrome | * Age-related changes in the bone marrow contribute to myelodysplastic syndrome | ||
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|Acute myeloid leukemia | |Acute myeloid leukemia | ||
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* Sanctuary sites include the central nervous system (CNS) and testes<ref name="pmid23523389">{{cite journal| author=Inaba H, Greaves M, Mullighan CG| title=Acute lymphoblastic leukaemia. | journal=Lancet | year= 2013 | volume= 381 | issue= 9881 | pages= 1943-55 | pmid=23523389 | doi=10.1016/S0140-6736(12)62187-4 | pmc=3816716 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23523389 }} </ref> | * Sanctuary sites include the central nervous system (CNS) and testes<ref name="pmid23523389">{{cite journal| author=Inaba H, Greaves M, Mullighan CG| title=Acute lymphoblastic leukaemia. | journal=Lancet | year= 2013 | volume= 381 | issue= 9881 | pages= 1943-55 | pmid=23523389 | doi=10.1016/S0140-6736(12)62187-4 | pmc=3816716 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23523389 }} </ref> | ||
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| | |Waldenstrom's macroglobulinemia | ||
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* | * ''MYD88'' mutation | ||
* | * Lymphoplasmacytic cell proliferation | ||
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* Elevated [[ | * Elevated [[immunoglobulin M]] (IgM) [[paraprotein]] | ||
* Presence of M-spike on protein electrophoresis | |||
* Presence of | * Elevated serum free light chains (''kappa'' and ''lambda'') | ||
* Increased serum viscosity | |||
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* Hepatomegaly | |||
* Splenomegaly | * Splenomegaly | ||
* | * Retinal vascular dilation and thrombosis | ||
* | * Decreased visual acuity | ||
* | * Headache | ||
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* [[ | * [[Rituximab]] | ||
* [[ | * [[Ibrutinib]] | ||
* [[ | * [[Plasmapheresis]] | ||
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* | * ''MYD88'' mutation testing is standard-of-care | ||
* | * Plasmapheresis should be initiated if symptoms of hyperviscosity are present | ||
* Typically does not require [[stem cell transplant]] | * Typically does not require [[stem cell transplant]] | ||
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|[[ | |[[Lymphoproliferative disorder]]<ref name="pmid28102226">{{cite journal| author=Kipps TJ, Stevenson FK, Wu CJ, Croce CM, Packham G, Wierda WG et al.| title=Chronic lymphocytic leukaemia. | journal=Nat Rev Dis Primers | year= 2017 | volume= 3 | issue= | pages= 16096 | pmid=28102226 | doi=10.1038/nrdp.2016.96 | pmc=5336551 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28102226 }} </ref> | ||
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* [[Epstein-Barr virus]] (EBV) | |||
* [[Human immunodeficiency virus]] (HIV) | |||
* [[Human T cell lymphotrophic virus-1]] (HTLV-1) | |||
* Post-transplant status ([[post-transplant lymphoproliferative disorder]] (PTLD)) | |||
* Chromosomal instability | * Chromosomal instability | ||
* Sporadic mutations | * Sporadic mutations | ||
* | * Rheumatologic disease | ||
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* Elevated | * Elevated lymphocyte count with presence of clonality | ||
* Anemia | |||
* Anemia | * Thrombocytopenia | ||
* Thrombocytopenia | * Neutropenia | ||
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* [[Lymph node enlargement]] | * [[Lymph node enlargement]] | ||
* [[Splenomegaly]] | * [[Splenomegaly]] | ||
* [[Hepatomegaly | * [[Hepatomegaly]] | ||
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* | * Variable based on the etiology | ||
* | * Cytotoxic chemotherapy | ||
* | * Antiviral agents | ||
* | * Biologic therapy with anti-CD20 monoclonal antibodies | ||
* | * Tapering immunosuppressive medications (for post-transplant lymphoproliferative disorder) | ||
| | | | ||
* | * Can be due to a variety of causes | ||
* | * Variable prognosis | ||
|} | |} | ||
Revision as of 03:49, 10 June 2018
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Myeloproliferative Neoplasm Microchapters |
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Differentiating myeloproliferative neoplasm from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Myeloproliferative neoplasm differential diagnosis On the Web |
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American Roentgen Ray Society Images of Myeloproliferative neoplasm differential diagnosis |
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Myeloproliferative neoplasm differential diagnosis in the news |
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Directions to Hospitals Treating Myeloproliferative neoplasm |
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Risk calculators and risk factors for Myeloproliferative neoplasm differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2] Shyam Patel [3]
Overview
Myeloproliferative neoplasm must be differentiated from acute lymphoblastic leukemia, acute myelogenous leukemia, chronic myelogenous leukemia, essential thrombocytosis, hypereosinophilic syndrome, non-Hodgkin lymphoma, primary myelofibrosis, secondary thrombocytosis, splenomegaly, systemic mastocytosis, and waldenstrom macroglobulinemia.
Differentiating Myeloproliferative neoplasm from other Diseases
| Characteristic | Causes | Laboratory abnormalities | Physical examination | Therapy | Other associations |
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| Myelodysplastic syndrome |
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| Acute myeloid leukemia |
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| Acute lymphoblastic leukemia |
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| Waldenstrom's macroglobulinemia |
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| Lymphoproliferative disorder[4] |
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References
- ↑ Döhner H, Estey E, Grimwade D, Amadori S, Appelbaum FR, Büchner T; et al. (2017). "Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel". Blood. 129 (4): 424–447. doi:10.1182/blood-2016-08-733196. PMC 5291965. PMID 27895058.
- ↑ Terwilliger T, Abdul-Hay M (2017). "Acute lymphoblastic leukemia: a comprehensive review and 2017 update". Blood Cancer J. 7 (6): e577. doi:10.1038/bcj.2017.53. PMC 5520400. PMID 28665419.
- ↑ Inaba H, Greaves M, Mullighan CG (2013). "Acute lymphoblastic leukaemia". Lancet. 381 (9881): 1943–55. doi:10.1016/S0140-6736(12)62187-4. PMC 3816716. PMID 23523389.
- ↑ Kipps TJ, Stevenson FK, Wu CJ, Croce CM, Packham G, Wierda WG; et al. (2017). "Chronic lymphocytic leukaemia". Nat Rev Dis Primers. 3: 16096. doi:10.1038/nrdp.2016.96. PMC 5336551. PMID 28102226.