Mumps natural history, complications and prognosis: Difference between revisions

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==Complications==
==Complications==
*While symptoms are generally not severe in children, the symptoms in teenagers and adults can be more severe and complications such as [[infertility]] or [[subfertility]] are relatively common, although still rare in absolute terms.<ref>{{cite journal | author=Preveden T, Jovanovic J, Ristic D | title=Fertility in men after mumps infection without manifestations of orchitis] | journal=Med Pregl | year=1996 | pages=99-102 | volume=49 | issue=3-4 | id={{PMID|8692089}} }}</ref><sup> </sup><ref>{{cite journal | author=Shakhov EV, Krupin VN | title=[The clinico-statistical characteristics of the testicular generative function in male subfertility following mumps] | journal=Urol Nefrol (Mosk) | year=1990 | pages=46-50 | volume= | issue=2 | id={{PMID|2368216}} }}</ref><sup> </sup><ref>{{cite journal | author=Tsvetkov D | title=[Spermatological disorders in patients with postmumps orchitis] | journal=Akush Ginekol (Sofiia) | year=1990 | pages=46-9 | volume=29 | issue=6 | id={{PMID|2100952}} }}</ref>
*Symptoms in teenagers and adults may be more severe.
*Complications may occur even if the patient does not have [[salivary gland enlargement|swollen salivary glands]] ([[parotitis]]) and are more common in people who have reached puberty.
*Complications are relatively rare but may occur in asymptomatic patients and are more common in people who have reached puberty.
*Rare complications of mumps include:
*The most common complication is [[orchitis]] in post-pubertal males.<ref name="CDCMumps">Mumps. Centers for Disease Control and Prevention (May 29, 2015). http://www.cdc.gov/mumps/index.html Accessed March 09, 2016.</ref>
:*Profound (91 dB or more) but rare [[sensorineural hearing loss]] which may be either unilateral or bilateral
:*Occurs in approximately 20% of cases in this sub-population
:*Mild forms of [[meningitis]] (~40% of cases occur without parotid swelling)
:*Orchitis is typically unilateral and atrophy may occur
:*[[Encephalitis]] (very rare, rarely fatal)
:*[[Infertility]] or [[subfertility]] is rare but may occur<ref>{{cite journal | author=Preveden T, Jovanovic J, Ristic D | title=Fertility in men after mumps infection without manifestations of orchitis | journal=Med Pregl | year=1996 | pages=99-102 | volume=49 | issue=3-4 | id={{PMID|8692089}} }}</ref><sup> </sup><ref>{{cite journal | author=Shakhov EV, Krupin VN | title=The clinico-statistical characteristics of the testicular generative function in male subfertility following mumps | journal=Urol Nefrol (Mosk) | year=1990 | pages=46-50 | volume= | issue=2 | id={{PMID|2368216}} }}</ref><sup> </sup><ref>{{cite journal | author=Tsvetkov D | title=Spermatological disorders in patients with postmumps orchitis | journal=Akush Ginekol (Sofiia) | year=1990 | pages=46-9 | volume=29 | issue=6 | id={{PMID|2100952}} }}</ref>
:*Mumps viral infections in adolescent and adult males carry an up to 30% risk that the testes may become infected ([[orchitis]] or [[epididymitis]]), which can be quite painful; about half of these infections result in [[testicular atrophy]], and in rare cases sterility can follow.
*Other complications of mumps include:<ref name="pmid10063655">{{cite journal| author=Galazka AM, Robertson SE, Kraigher A| title=Mumps and mumps vaccine: a global review. | journal=Bull World Health Organ | year= 1999 | volume= 77 | issue= 1 | pages= 3-14 | pmid=10063655 | doi= | pmc=PMC2557572 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10063655  }} </ref><ref name="Gupta2005">{{cite journal|last1=Gupta|first1=R. K|title=Mumps and the UK epidemic 2005|journal=BMJ|volume=330|issue=7500|year=2005|pages=1132–1135|issn=0959-8138|doi=10.1136/bmj.330.7500.1132}}</ref>
:*[[Oophoritis]] and/or [[mastitis]] in approximately 5% of post-pubertal females
:*Unilateral or less common bilateral transient [[sensorineural hearing loss]] - permanent deafness has occurred but is rare<ref name="pmid19209100">{{cite journal| author=Hashimoto H, Fujioka M, Kinumaki H, Kinki Ambulatory Pediatrics Study Group| title=An office-based prospective study of deafness in mumps. | journal=Pediatr Infect Dis J | year= 2009 | volume= 28 | issue= 3 | pages= 173-5 | pmid=19209100 | doi=10.1097/INF.0b013e31818a8ca8 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19209100  }} </ref>
:*[[Meningitis]]
:*[[Encephalitis]]
:*Spontaneous abortion in about 27% of cases during the first trimester of pregnancy.
:*Spontaneous abortion in about 27% of cases during the first trimester of pregnancy.
:*[[Pancreatitis]] in about 4% of cases, manifesting as abdominal pain and [[vomiting]]
:*[[Pancreatitis]] in about 5% of cases<ref name="pmid8582424">{{cite journal| author=Nussinovitch M, Volovitz B, Varsano I| title=Complications of mumps requiring hospitalization in children. | journal=Eur J Pediatr | year= 1995 | volume= 154 | issue= 9 | pages= 732-4 | pmid=8582424 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8582424  }} </ref>
:*[[Oophoritis]] and/or [[mastitis]] in females who have reached puberty


==Prognosis==
==Prognosis==

Revision as of 18:45, 10 March 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Lakshmi Gopalakrishnan, M.B.B.S. [2]; Nate Michalak, B.A.

Overview

A majority of the patients infected with mumps usually recover completely. However, mumps can occasionally cause complications, and some of them can be serious. Complications may occur even if the patient does not have swollen salivary glands (parotitis) and are more common in people who have reached puberty.

Natural History

Complications

  • Symptoms in teenagers and adults may be more severe.
  • Complications are relatively rare but may occur in asymptomatic patients and are more common in people who have reached puberty.
  • The most common complication is orchitis in post-pubertal males.[1]
  • Occurs in approximately 20% of cases in this sub-population
  • Orchitis is typically unilateral and atrophy may occur
  • Infertility or subfertility is rare but may occur[2] [3] [4]
  • Other complications of mumps include:[5][6]

Prognosis

The disease is self-limiting, and the prognosis is generally good, even if other organs are involved. After the illness, life-long immunity to mumps generally occurs. Sterility in men secondary to testicular involvement and death are very rare occurrences.

Resources

CDC: Mumps Complications

References

  1. Mumps. Centers for Disease Control and Prevention (May 29, 2015). http://www.cdc.gov/mumps/index.html Accessed March 09, 2016.
  2. Preveden T, Jovanovic J, Ristic D (1996). "Fertility in men after mumps infection without manifestations of orchitis". Med Pregl. 49 (3–4): 99–102. PMID 8692089.
  3. Shakhov EV, Krupin VN (1990). "The clinico-statistical characteristics of the testicular generative function in male subfertility following mumps". Urol Nefrol (Mosk) (2): 46–50. PMID 2368216.
  4. Tsvetkov D (1990). "Spermatological disorders in patients with postmumps orchitis". Akush Ginekol (Sofiia). 29 (6): 46–9. PMID 2100952.
  5. Galazka AM, Robertson SE, Kraigher A (1999). "Mumps and mumps vaccine: a global review". Bull World Health Organ. 77 (1): 3–14. PMC 2557572. PMID 10063655.
  6. Gupta, R. K (2005). "Mumps and the UK epidemic 2005". BMJ. 330 (7500): 1132–1135. doi:10.1136/bmj.330.7500.1132. ISSN 0959-8138.
  7. Hashimoto H, Fujioka M, Kinumaki H, Kinki Ambulatory Pediatrics Study Group (2009). "An office-based prospective study of deafness in mumps". Pediatr Infect Dis J. 28 (3): 173–5. doi:10.1097/INF.0b013e31818a8ca8. PMID 19209100.
  8. Nussinovitch M, Volovitz B, Varsano I (1995). "Complications of mumps requiring hospitalization in children". Eur J Pediatr. 154 (9): 732–4. PMID 8582424.


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