Multiple endocrine neoplasia type 1 natural history, complications and prognosis: Difference between revisions
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{{CMG}}; {{AE}} {{Ammu}} | {{CMG}}; {{AE}} {{Ammu}} | ||
==Overview== | ==Overview== | ||
Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good. | Depending on the extent of the [[tumor]] at the time of [[diagnosis]], the [[prognosis]] may vary. However, the [[prognosis]] is generally regarded as good. | ||
==Natural History== | ==Natural History== | ||
The | The [[symptom]]s of multiple endocrine neoplasia type 1 usually develop in the first/ second/ third decade of life and the age at which multiple endocrine neoplasia type 1 can begin to cause [[endocrine gland]] overactivity can differ strikingly from one family member to another. One person may have only mild [[hyperparathyroidism]] beginning at age 50, while a relative may develop complications from [[tumor]]s of the [[parathyroid]], [[pancreas]], and [[pituitary]] by age 18. Multiple endocrine neoplasia type 1 cannot be cured, but regular testing can detect many of the problems caused by multiple endocrine neoplasia type 1 tumors many years before serious complications develop. Even after treatment, residual tissue can grow back or different [[gland]]s may become affected. Most people with multiple endocrine neoplasia type 1 have a long and productive life. | ||
==Complications== | ==Complications== | ||
* Complications that can develop as a result of multiple endocrine neoplasia type 1 are as below.<ref name="pmid19904212">{{cite journal| author=Falchetti A, Marini F, Luzi E, Giusti F, Cavalli L, Cavalli T et al.| title=Multiple endocrine neoplasia type 1 (MEN1): not only inherited endocrine tumors. | journal=Genet Med | year= 2009 | volume= 11 | issue= 12 | pages= 825-35 | pmid=19904212 | doi=10.1097/GIM.0b013e3181be5c97 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19904212 }} </ref> | * Complications that can develop as a result of multiple endocrine neoplasia type 1 are as below.<ref name="pmid19904212">{{cite journal| author=Falchetti A, Marini F, Luzi E, Giusti F, Cavalli L, Cavalli T et al.| title=Multiple endocrine neoplasia type 1 (MEN1): not only inherited endocrine tumors. | journal=Genet Med | year= 2009 | volume= 11 | issue= 12 | pages= 825-35 | pmid=19904212 | doi=10.1097/GIM.0b013e3181be5c97 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19904212 }} </ref> | ||
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==Prognosis== | ==Prognosis== | ||
* The prognosis of multiple endocrine neoplasia type 1 is good with treatment. | * The [[prognosis]] of multiple endocrine neoplasia type 1 is good with treatment. | ||
* Most people with | * Most people with multiple endocrine neoplasia type 1 have a long and productive life. | ||
* Early death can occur due to the effect of | * Early death can occur due to the effect of [[hormone]]s produced by these [[tumor]]s. | ||
* Although many | * Although many [[tumor]]s associated with multiple endocrine neoplasia type 1 are [[benign]], about half of people with multiple endocrine neoplasia type 1 will eventually develop a cancerous [[tumor]]. | ||
* The presence of [[pancreatic tumor]]s is associated with a particularly poor prognosis among patients with multiple endocrine neoplasia type 1. | * The presence of [[pancreatic tumor]]s is associated with a particularly poor [[prognosis]] among patients with multiple endocrine neoplasia type 1. | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Hereditary cancers]] | [[Category:Hereditary cancers]] | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good.
Natural History
The symptoms of multiple endocrine neoplasia type 1 usually develop in the first/ second/ third decade of life and the age at which multiple endocrine neoplasia type 1 can begin to cause endocrine gland overactivity can differ strikingly from one family member to another. One person may have only mild hyperparathyroidism beginning at age 50, while a relative may develop complications from tumors of the parathyroid, pancreas, and pituitary by age 18. Multiple endocrine neoplasia type 1 cannot be cured, but regular testing can detect many of the problems caused by multiple endocrine neoplasia type 1 tumors many years before serious complications develop. Even after treatment, residual tissue can grow back or different glands may become affected. Most people with multiple endocrine neoplasia type 1 have a long and productive life.
Complications
- Complications that can develop as a result of multiple endocrine neoplasia type 1 are as below.[1]
Prognosis
- The prognosis of multiple endocrine neoplasia type 1 is good with treatment.
- Most people with multiple endocrine neoplasia type 1 have a long and productive life.
- Early death can occur due to the effect of hormones produced by these tumors.
- Although many tumors associated with multiple endocrine neoplasia type 1 are benign, about half of people with multiple endocrine neoplasia type 1 will eventually develop a cancerous tumor.
- The presence of pancreatic tumors is associated with a particularly poor prognosis among patients with multiple endocrine neoplasia type 1.
References
- ↑ Falchetti A, Marini F, Luzi E, Giusti F, Cavalli L, Cavalli T; et al. (2009). "Multiple endocrine neoplasia type 1 (MEN1): not only inherited endocrine tumors". Genet Med. 11 (12): 825–35. doi:10.1097/GIM.0b013e3181be5c97. PMID 19904212.