Multiple endocrine neoplasia type 1 natural history, complications and prognosis: Difference between revisions
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==Complications== | ==Complications== | ||
* Complications that can develop as a result of multiple endocrine neoplasia type 1 are as | * Complications that can develop as a result of multiple endocrine neoplasia type 1 are as below.<ref name="pmid19904212">{{cite journal| author=Falchetti A, Marini F, Luzi E, Giusti F, Cavalli L, Cavalli T et al.| title=Multiple endocrine neoplasia type 1 (MEN1): not only inherited endocrine tumors. | journal=Genet Med | year= 2009 | volume= 11 | issue= 12 | pages= 825-35 | pmid=19904212 | doi=10.1097/GIM.0b013e3181be5c97 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19904212 }} </ref> | ||
:* [[Necrolytic migratory erythema]] | |||
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:* [[Cushing's syndrome]] | :* [[Cushing's syndrome]] | ||
:* [[Gynecomastia]] | |||
:* [[Gigantism]] | |||
:* [[Acromegaly]] | |||
:* [[Paresis]] | |||
:* [[Ataxia]] | |||
:* [[Convulsions]] | |||
:* [[Infertility]] | :* [[Infertility]] | ||
:* [[Impotency]] | :* [[Impotency]] | ||
:* [[Kidney stone]]s | :* [[Kidney stone]]s | ||
:* [[ | :* [[Venous thrombosis]] | ||
:* [[ | :* [[Glossitis]] | ||
:* [[Anemia]] | |||
==Prognosis== | ==Prognosis== |
Revision as of 13:12, 9 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Natural History
The symptoms of multiple endocrine neoplasia type 1 usually develop in the first/ second/ third decade of life and the age at which MEN1 can begin to cause endocrine gland overactivity can differ strikingly from one family member to another. One person may have only mild hyperparathyroidism beginning at age 50, while a relative may develop complications from tumors of the parathyroid, pancreas, and pituitary by age 18. MEN1 cannot be cured, but regular testing can detect many of the problems caused by MEN1 tumors many years before serious complications develop. Even after treatment, residual tissue can grow back or different glands may become affected. Most people with MEN1 have a long and productive life.
Complications
- Complications that can develop as a result of multiple endocrine neoplasia type 1 are as below.[1]
Prognosis
- The prognosis of multiple endocrine neoplasia type 1 is good with treatment.
- Most people with MEN1 have a long and productive life.
- Although many tumors associated with MEN1 are benign, about half of people with MEN1 will eventually develop a cancerous tumor.
- The presence of pancreatic tumors is associated with a particularly poor prognosis among patients with multiple endocrine neoplasia type 1.
References
- ↑ Falchetti A, Marini F, Luzi E, Giusti F, Cavalli L, Cavalli T; et al. (2009). "Multiple endocrine neoplasia type 1 (MEN1): not only inherited endocrine tumors". Genet Med. 11 (12): 825–35. doi:10.1097/GIM.0b013e3181be5c97. PMID 19904212.