Meningioma classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Meningioma may be classified according to the histological criteria of the WHO into 3 groups: benign classic meningioma (WHO grade 1), atypical meningioma (WHO grade 2), and anaplastic malignant meningioma (WHO grade 3). Meningioma may also be classified according to the tumor location into 2 main subtypes: intradural and extradural meningioma.[1][2]
Classification
- WHO has classified meningiomas into 15 histo- and cytomorphological variants. Nine variants correspond to WHO grade I which are the benign classic meningiomas, three correspond to WHO grade II which are atypical meningiomas, the other three are in WHO grade III and are anaplastic malignant meningiomas.[3]
- WHO grade I: They are low-grade tumors that grow very slowly and rarely invade the surrounding tissues.
- WHO grade II: These are not clearly malignant, but grow faster than benign meningiomas. They have increased mitosis and can invade the brain. They could possess increased cellularity, small cells with high nuclear-to-cytoplasmic ratio, prominent nucleoli, sheeting, foci of spontaneous necrosis (at least three of these features).
- WHO grade III: Markedly increased mitosis with and overtly malignant cytology.
- The table below lists the subtypes of meningioma according to the WHO grades:[3]
| WHO grade | Subtypes |
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Benign classic meningioma |
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Atypical meningioma |
Chordoid, clear cell, and atypical meningioma. clear cell meningioma |
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Anaplastic malignant meningioma |
Rhabdoid, papillary, and anaplastic meningioma |
- Meningioma may also be classified according to the tumor location into 2 main subtypes: intradural and extradural meningioma.[1][2]
References
- ↑ 1.0 1.1 Meningioma diagnosis. Wikipedia (2015) https://en.wikipedia.org/wiki/Meningioma#History_and_nomenclature Accessed on September, 25 2015
- ↑ 2.0 2.1 Meningioma. Liberpathology(2015) http://librepathology.org/wiki/index.php/Meningioma#Quick_overview Accessed on September, 25 2015
- ↑ 3.0 3.1 Harter, Patrick N.; Braun, Yannick; Plate, Karl H. (2017). "Classification of meningiomas—advances and controversies". Chinese Clinical Oncology. 6 (S1): S2–S2. doi:10.21037/cco.2017.05.02. ISSN 2304-3865.