Medullary thyroid cancer staging
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
According to the American Joint Committee on Cancer (AJCC)[1] there are 4 stages of medullary thyroid cancer based on the clinical features and findings on imaging. Each stage is assigned a letter and a number that designate the tumor size, number of involved lymph node regions, and metastasis.
Staging
Stage | Description |
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TX | Primary tumor cannot be assessed |
T0 | No evidence of primary tumor |
T1 | Tumor ≤2 cm in greatest dimension limited to the thyroid |
T1a | Tumor ≤1 cm, limited to the thyroid |
T1b | Tumor >1 cm but ≤2 cm in greatest dimension, limited to the thyroid |
T2 | Tumor >2 cm but ≤4 cm in greatest dimension, limited to the thyroid |
T3 | Tumor >4 cm in greatest dimension limited to the thyroid or any tumor with minimal extrathyroid extension (e.g., extension to sternothyroid muscle or perithyroid soft tissues) |
T4a | Moderately advanced disease |
Tumor of any size extending beyond the thyroid capsule to invade subcutaneous soft tissues, larynx, trachea, esophagus, or recurrent laryngeal nerve | |
T4b | Very advanced disease |
Tumor invades prevertebral fascia or encases carotid artery or mediastinal vessel |
Stage | Description |
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NX | Regional lymph node cannot be assessed |
N0 | No regional lymph node metastasis |
N1 | Regional lymph node metastasis |
N1a | Metastases to Level VI (pretracheal, paratracheal, and prelaryngeal/Delphian lymph nodes) |
N1b | Metastases to unilateral, bilateral, or contralateral cervical (Levels I, II, III, IV, or V) or retropharyngeal or superior mediastinal lymph nodes (Level VII) |
Stage | Description |
---|---|
M0 | No distant metastasis |
M1 | Distant metastasis |
Stage | T | N | M |
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Medullary carcinoma (all age groups) | |||
I | T1 | N0 | M0 |
II | T2 | N0 | M0 |
T3 | N0 | M0 | |
III | T1 | N1a | M0 |
T2 | N1a | M0 | |
T3 | N1a | M0 | |
IVa | T4a | N0 | M0 |
T4a | N1a | M0 | |
T1 | N1b | M0 | |
T2 | N1b | M0 | |
T3 | N1b | M0 | |
T4a | N1b | M0 | |
Stage IVb | T4b | Any N | |
IVB | T4b | Any N | M0 |
IVC | Any T | Any N | M1 |
Medullary Thyroid Cancer
- Several staging systems have been employed to correlate extent of disease with long-term survival in medullary thyroid cancer. The clinical staging system of the AJCC correlates survival to size of the primary tumor, presence or absence of lymph node metastases, and presence or absence of distance metastasis. Patients with the best prognosis are those who are diagnosed by provocative screening, prior to the appearance of palpable disease.
Stage 0 Medullary Thyroid Cancer
- Clinically occult disease detected by provocative biochemical screening
Stage I Medullary Thyroid Cancer
- Tumor smaller than 2 cm
Stage II Medullary Thyroid Cancer
- Tumor larger than 2 cm but 4 cm or smaller with no metastases or larger than 4 cm with minimal extrathyroid extension
Stage III Medullary Thyroid Cancer
- Tumor of any size with metastases limited to the pretracheal, paratracheal, or prelaryngeal/Delphian lymph nodes.
Stage IV Medullary Thyroid Cancer
- Stage IV medullary thyroid cancer is divided into the following categories:
- Stage IVA (moderately advanced with or without lymph node metastases [for T4a] but without distant metastases).
- Stage IVB (very advanced with or without lymph node metastases but no distant metastases).
- Stage IVC (distant metastases)
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Stage M1 thyroid cancer
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Stage N1a thyroid cancer
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Stage N1b thyroid cancer
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Stage T1a thyroid cancer
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Stage T1b thyroid cancer
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Stage T3 thyroid cancer
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Stage T4a thyroid cancer
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Stage T4b thyroid cancer
Reference
- ↑ Stage Information for Thyroid Cancer Cancer.gov (2015). http://www.cancer.gov/types/thyroid/hp/thyroid-treatment-pdq#link/stoc_h2_2- Accessed on October, 29 2015