Medullary thyroid cancer laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Laboratory findings consistent with the diagnosis of medullary thyroid cancer include decreased thyroid stimulating hormone, elevated calcitonin, and decreased calcium.

Laboratory Findings

  • Blood or imaging tests may be done prior to or in lieu of a biopsy. The following blood tests are conducted:
  • Tests for serum thyroid autoantibodies are done to rule out autoimmune thyroid disease.
  • Laboratory findings consistent with the diagnosis of multiple endocrine neoplasia type 2 are tabulated below.
Laboratory findings
Test Findings
Metabolic Decreased thyroid stimulating hormone
Antithyroid antibodies
Elevated calcitonin
Decreased calcium
Adapted from Arzu Tatlıpınar1 and İlkay Kartal [Updated 2015].The Evaluation of Thyroid Nodules. Journal of Thyroid Disorders & Therapy.2015.[1]
Laboratory tests Normal Range Abnormal value
Serum
Thyroid stimulating hormone 0.4 - 4.0 milli-international units per liter <0.4 or >4.0
Antithyroid antibodies <35 IU/mL >35 IU/mL
Serum calcitonin less than 10pg/mL >=100 pg/mL
Serum calcium 8.9-10.1 mg/dL > 10.1 mg/dL or < 8.9 mg/dL

References

  1. İlkay Kartal, Arzu Tatlıpınar (2014). "The Evaluation of Thyroid Nodules". Journal of Thyroid Disorders and Therapy. 04 (02). doi:10.4172/2167-7948.1000181. ISSN 2167-7948.

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