Mast cell tumor natural history, complications and prognosis: Difference between revisions
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Localized mastocytosis | |||
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*Mastocytoma: benign tumor with good prognosis | |||
*Mast cell sarcoma: Poor prognosis | |||
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Revision as of 19:17, 7 March 2016
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Overview
Common complications of mast cell tumor include episodes of anaphylaxis, osteoporosis, and progression to malignant mastocytosis or mast cell leukemia.
Natural History
- Mast cell tumor usually occurs as a sporadic disease that is often transient and limited in children and progressive in adults.
- Systemic mastocytosis may develop in childhood cases of urticaria pigmentosa that persist beyond puberty, and in approximately 40% of adults with urticaria pigmentosa, usually of long standing.
- Patients with mast cell tumor often initially have symptom-free intervals interspersed among symptomatic periods.
- Over time, symptom-free intervals shorten, and finally symptoms become chronic with intensity which fluctuates but with an overall trend toward steadily increasing intensity.
Complications
Common complications of mast cell tumor include:
- Anaphylaxis
- Osteoporosis
- Systemic mastocytosis may progress to malignant mastocytosis and/ or mast cell leukemia
Prognosis
The prognosis varies with the location of tumor:
Subtype | Prognosis |
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Cutaneous mastocytosis |
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Systemic mastocytosis |
Prognosis varies with degree of hematological and organ involvement
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Localized mastocytosis |
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