Marburg hemorrhagic fever laboratory findings: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Marburg hemorrhagic fever}} | {{Marburg hemorrhagic fever}} | ||
{{CMG}}{{AE}} | {{CMG}} {{AE}} {{ARK}} | ||
==Overview== | ==Overview== | ||
Marburg virus infection may be confirmed by the laboratory techniques such as antibody-capture [[enzyme-linked immunosorbent assay]], antigen-capture detection tests, serum neutralization test, [[reverse transcriptase]] [[polymerase chain reaction]] ([[RT-PCR]]), antigen detection tests and virus isolation by cell culture. | |||
==Laboratory Studies== | ==Laboratory Studies== | ||
*It may be a challenge to clinically distinguish marburg virus disease (MVD) from other infectious diseases such as [[malaria]], [[typhoid fever]], [[shigellosis]], [[meningitis]] and other [[Viral hemorrhagic fever|viral haemorrhagic fevers]]. Marburg virus infection may be confirmed using the following diagnostic methods: | |||
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! style="width: 500px;background: #4479BA" |{{fontcolor|#FFF| '''''Lab test for Marburg virus detection''''' <ref name="urlWHO | Marburg haemorrhagic fever">{{cite web |url=http://www.who.int/mediacentre/factsheets/fs_marburg/en/ |title=WHO | Marburg haemorrhagic fever |format= |work= |accessdate=}}</ref>}} | |||
{|style="border: 0px; font-size: 90%; margin: 3px; width: 500px;" align=center | |||
! style="width: 500px;background: #4479BA"|{{fontcolor|#FFF| '''''Lab test for Marburg virus detection''''' <ref name="urlWHO | Marburg haemorrhagic fever">{{cite web |url=http://www.who.int/mediacentre/factsheets/fs_marburg/en/ |title=WHO | Marburg haemorrhagic fever |format= |work= |accessdate=}}</ref>}} | |||
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| | | style="padding: 0 5px; width: 120px; background: #F5F5F5" |[[antibody-capture enzyme-linked immunosorbent assay]] (ELISA) | ||
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| | | style="padding: 0 5px; width: 120px;background: #DCDCDC" |[[antigen-capture detection tests]] | ||
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| | | style="padding: 0 5px; width: 120px;background: #F5F5F5" |[[Serum neutralization test]] | ||
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| | | style="padding: 0 5px; width: 120px;background: #DCDCDC" |[[Reverse-transcriptase]] [[polymerase chain reaction]] (RT-PCR) assay | ||
|- | |- | ||
| | | style="padding: 0 5px; width: 120px;background: #DCDCDC" |[[Antigen]] detection tests | ||
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| | | style="padding: 0 5px; width: 120px;background: #F5F5F5" |[[Virus]] isolation by [[cell culture]] | ||
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Tests on clinical samples present an extreme biohazard risk and are conducted only under maximum biological containment conditions. In deceased patients, [[immunohistochemistry]], virus isolation, or [[PCR]] of [[blood]] or [[tissue]] specimens may be used to diagnose Marburg HF retrospectively. | *Tests on clinical samples present an extreme biohazard risk and are conducted only under maximum biological containment conditions. In deceased patients, [[immunohistochemistry]], virus isolation, or [[PCR]] of [[blood]] or [[tissue]] specimens may be used to diagnose Marburg HF retrospectively. | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
Latest revision as of 11:27, 23 October 2017
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Marburg hemorrhagic fever Microchapters |
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Differentiating Marburg hemorrhagic fever from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Marburg hemorrhagic fever laboratory findings On the Web |
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American Roentgen Ray Society Images of Marburg hemorrhagic fever laboratory findings |
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Risk calculators and risk factors for Marburg hemorrhagic fever laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]
Overview
Marburg virus infection may be confirmed by the laboratory techniques such as antibody-capture enzyme-linked immunosorbent assay, antigen-capture detection tests, serum neutralization test, reverse transcriptase polymerase chain reaction (RT-PCR), antigen detection tests and virus isolation by cell culture.
Laboratory Studies
- It may be a challenge to clinically distinguish marburg virus disease (MVD) from other infectious diseases such as malaria, typhoid fever, shigellosis, meningitis and other viral haemorrhagic fevers. Marburg virus infection may be confirmed using the following diagnostic methods:
| Lab test for Marburg virus detection [1] |
|---|
| antibody-capture enzyme-linked immunosorbent assay (ELISA) |
| antigen-capture detection tests |
| Serum neutralization test |
| Reverse-transcriptase polymerase chain reaction (RT-PCR) assay |
| Antigen detection tests |
| Virus isolation by cell culture |
- Tests on clinical samples present an extreme biohazard risk and are conducted only under maximum biological containment conditions. In deceased patients, immunohistochemistry, virus isolation, or PCR of blood or tissue specimens may be used to diagnose Marburg HF retrospectively.