MED6: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
{{Infobox protein family
| update_page = yes
| Symbol = Med6
| require_manual_inspection = no
| Name = Med6
| update_protein_box = yes
| image =
| update_summary = yes
| width =
| update_citations = yes
| caption =
| Pfam = PF04934
| Pfam_clan = 
| InterPro = IPR007018
| SMART =
| PROSITE =
| MEROPS =
| SCOP =
| TCDB =  
| OPM family =  
| OPM protein =  
| CAZy =  
| CDD =  
}}
}}
'''Mediator of RNA polymerase II transcription subunit 6''' is one of the subunits of the [[Mediator complex]]. It is an [[enzyme]] that in humans is encoded by the ''MED6'' [[gene]].<ref name="pmid9234719" /><ref name="pmid9671713">{{cite journal | vauthors = Jiang YW, Veschambre P, Erdjument-Bromage H, Tempst P, Conaway JW, Conaway RC, Kornberg RD | title = Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 15 | pages = 8538–8543 | date = Aug 1998 | pmid = 9671713 | pmc = 21111 | doi = 10.1073/pnas.95.15.8538 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MED6 mediator of RNA polymerase II transcription, subunit 6 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10001| accessdate = }}</ref>


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Protein family ==
{{GNF_Protein_box
 
| image =
This [[protein family|family of proteins]] represent the transcriptional mediator protein subunit 6 that is required for [[gene activation|activation]] of many RNA polymerase II [[Promoter (biology)|promoter]]s and which are [[conserved sequence|conserved]] from [[yeast]] to [[human]]s.<ref name="pmid9234719">{{cite journal | vauthors = Lee YC, Min S, Gim BS, Kim YJ | title = A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans | journal = Mol. Cell. Biol. | volume = 17 | issue = 8 | pages = 4622–32 | date = August 1997 | pmid = 9234719 | pmc = 232315 | doi =  }}</ref>
| image_source =
 
| PDB =
== Interactions ==
| Name = Mediator of RNA polymerase II transcription, subunit 6 homolog (S. cerevisiae)
 
| HGNCid = 19970
MED6 has been shown to [[Protein-protein interaction|interact]] with:
| Symbol = MED6
* [[Cyclin-dependent kinase 8]],<ref name = pmid14983011>{{cite journal | vauthors = Yang F, DeBeaumont R, Zhou S, Näär AM | title = The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 8 | pages = 2339–44 | date = Feb 2004 | pmid = 14983011 | pmc = 356952 | doi = 10.1073/pnas.0308676100}}</ref><ref name = pmid11416138>{{cite journal | vauthors = Wang G, Cantin GT, Stevens JL, Berk AJ | title = Characterization of mediator complexes from HeLa cell nuclear extract | journal = Mol. Cell. Biol. | volume = 21 | issue = 14 | pages = 4604–13 | date = Jul 2001 | pmid = 11416138 | pmc = 87123 | doi = 10.1128/MCB.21.14.4604-4613.2001 }}</ref><ref name = pmid10198638/><ref name = pmid11867769/>
| AltSymbols =; NY-REN-28
* [[Estrogen receptor alpha]],<ref name = pmid11867769>{{cite journal | vauthors = Kang YK, Guermah M, Yuan CX, Roeder RG | title = The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 5 | pages = 2642–7 | date = Mar 2002 | pmid = 11867769 | pmc = 122401 | doi = 10.1073/pnas.261715899 }}</ref>
| OMIM = 602984
* [[MED21]],<ref name = pmid9734358>{{cite journal | vauthors = Sun X, Zhang Y, Cho H, Rickert P, Lees E, Lane W, Reinberg D | title = NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription | journal = Mol. Cell | volume = 2 | issue = 2 | pages = 213–22 | date = Aug 1998 | pmid = 9734358 | doi =  10.1016/s1097-2765(00)80131-8}}</ref>  and
| ECnumber =   
* [[Thyroid hormone receptor alpha]].<ref name = pmid10198638>{{cite journal | vauthors = Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG | title = Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators | journal = Mol. Cell | volume = 3 | issue = 3 | pages = 361–70 | date = Mar 1999 | pmid = 10198638 | doi = 10.1016/s1097-2765(00)80463-3}}</ref>
| Homologene = 3990
| MGIid = 1917042
| GeneAtlas_image1 = PBB_GE_MED6_207079_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MED6_210104_at_tn.png
| Function = {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000119 |text = mediator complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10001
    | Hs_Ensembl = ENSG00000133997
    | Hs_RefseqProtein = NP_005457
    | Hs_RefseqmRNA = NM_005466
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 70120059
    | Hs_GenLoc_end = 70137136
    | Hs_Uniprot = O75586
    | Mm_EntrezGene = 69792
    | Mm_Ensembl = ENSMUSG00000002679
    | Mm_RefseqmRNA = NM_027213
    | Mm_RefseqProtein = NP_081489
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 82492412
    | Mm_GenLoc_end = 82513850
    | Mm_Uniprot =   
  }}
}}
'''Mediator of RNA polymerase II transcription, subunit 6 homolog (S. cerevisiae)''', also known as '''MED6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MED6 mediator of RNA polymerase II transcription, subunit 6 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10001| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{PBB_Summary
{{reflist}}
| section_title =
| summary_text =
}}


==References==
== Further reading ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–174 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–156 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Sun X, Zhang Y, Cho H, Rickert P, Lees E, Lane W, Reinberg D | title = NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription | journal = Mol. Cell | volume = 2 | issue = 2 | pages = 213–222 | year = 1998 | pmid = 9734358 | doi = 10.1016/S1097-2765(00)80131-8 }}
*{{cite journal | author=Lee YC, Min S, Gim BS, Kim YJ |title=A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans. |journal=Mol. Cell. Biol. |volume=17 |issue= 8 |pages= 4622-32 |year= 1997 |pmid= 9234719 |doi= }}
* {{cite journal | vauthors = Gu W, Malik S, Ito M, Yuan CX, Fondell JD, Zhang X, Martinez E, Qin J, Roeder RG | title = A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation | journal = Mol. Cell | volume = 3 | issue = 1 | pages = 97–108 | year = 1999 | pmid = 10024883 | doi = 10.1016/S1097-2765(00)80178-1 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG | title = Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators | journal = Mol. Cell | volume = 3 | issue = 3 | pages = 361–370 | year = 1999 | pmid = 10198638 | doi = 10.1016/S1097-2765(00)80463-3 }}
*{{cite journal | author=Jiang YW, Veschambre P, Erdjument-Bromage H, ''et al.'' |title=Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 15 |pages= 8538-43 |year= 1998 |pmid= 9671713 |doi= }}
* {{cite journal | vauthors = Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, Erdjument-Bromage H, Tempst P, Freedman LP | title = Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex | journal = Nature | volume = 398 | issue = 6730 | pages = 824–828 | year = 1999 | pmid = 10235266 | doi = 10.1038/19783 }}
*{{cite journal | author=Sun X, Zhang Y, Cho H, ''et al.'' |title=NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. |journal=Mol. Cell |volume=2 |issue= 2 |pages= 213-22 |year= 1998 |pmid= 9734358 |doi= }}
* {{cite journal | vauthors = Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R | title = Composite co-activator ARC mediates chromatin-directed transcriptional activation | journal = Nature | volume = 398 | issue = 6730 | pages = 828–832 | year = 1999 | pmid = 10235267 | doi = 10.1038/19789 }}
*{{cite journal | author=Gu W, Malik S, Ito M, ''et al.'' |title=A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. |journal=Mol. Cell |volume=3 |issue= 1 |pages= 97-108 |year= 1999 |pmid= 10024883 |doi= }}
* {{cite journal | vauthors = Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ | title = Antigens recognized by autologous antibody in patients with renal-cell carcinoma | journal = Int. J. Cancer | volume = 83 | issue = 4 | pages = 456–464 | year = 1999 | pmid = 10508479 | doi = 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 }}
*{{cite journal | author=Ito M, Yuan CX, Malik S, ''et al.'' |title=Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. |journal=Mol. Cell |volume=3 |issue= 3 |pages= 361-70 |year= 1999 |pmid= 10198638 |doi= }}
* {{cite journal | vauthors = Ge K, Guermah M, Yuan CX, Ito M, Wallberg AE, Spiegelman BM, Roeder RG | title = Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis | journal = Nature | volume = 417 | issue = 6888 | pages = 563–567 | year = 2002 | pmid = 12037571 | doi = 10.1038/417563a }}
*{{cite journal | author=Rachez C, Lemon BD, Suldan Z, ''et al.'' |title=Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. |journal=Nature |volume=398 |issue= 6730 |pages= 824-8 |year= 1999 |pmid= 10235266 |doi= 10.1038/19783 }}
* {{cite journal | vauthors = Kato Y, Habas R, Katsuyama Y, Näär AM, He X | title = A component of the ARC/Mediator complex required for TGF beta/Nodal signalling | journal = Nature | volume = 418 | issue = 6898 | pages = 641–646 | year = 2002 | pmid = 12167862 | doi = 10.1038/nature00969 }}
*{{cite journal | author=Näär AM, Beaurang PA, Zhou S, ''et al.'' |title=Composite co-activator ARC mediates chromatin-directed transcriptional activation. |journal=Nature |volume=398 |issue= 6730 |pages= 828-32 |year= 1999 |pmid= 10235267 |doi= 10.1038/19789 }}
* {{cite journal | vauthors = Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW | title = Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3 | journal = J. Biol. Chem. | volume = 278 | issue = 17 | pages = 15123–15127 | year = 2003 | pmid = 12584197 | doi = 10.1074/jbc.C300054200 }}
*{{cite journal | author=Scanlan MJ, Gordan JD, Williamson B, ''et al.'' |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456-64 |year= 1999 |pmid= 10508479 |doi= }}
* {{cite journal | vauthors = Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW | title = A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex | journal = J. Biol. Chem. | volume = 278 | issue = 50 | pages = 49671–49674 | year = 2004 | pmid = 14576168 | doi = 10.1074/jbc.C300444200 }}
*{{cite journal | author=Ge K, Guermah M, Yuan CX, ''et al.'' |title=Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. |journal=Nature |volume=417 |issue= 6888 |pages= 563-7 |year= 2002 |pmid= 12037571 |doi= 10.1038/417563a }}
* {{cite journal | vauthors = Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW | title = A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 | journal = J. Biol. Chem. | volume = 279 | issue = 7 | pages = 5846–5851 | year = 2004 | pmid = 14638676 | doi = 10.1074/jbc.M312523200 }}
*{{cite journal | author=Kato Y, Habas R, Katsuyama Y, ''et al.'' |title=A component of the ARC/Mediator complex required for TGF beta/Nodal signalling. |journal=Nature |volume=418 |issue= 6898 |pages= 641-6 |year= 2002 |pmid= 12167862 |doi= 10.1038/nature00969 }}
* {{cite journal | vauthors = Yang F, DeBeaumont R, Zhou S, Näär AM | title = The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 8 | pages = 2339–2344 | year = 2004 | pmid = 14983011 | pmc = 356952 | doi = 10.1073/pnas.0308676100 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC | title = A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology | journal = Mol. Cell | volume = 14 | issue = 5 | pages = 685–691 | year = 2004 | pmid = 15175163 | doi = 10.1016/j.molcel.2004.05.006 }}
*{{cite journal | author=Sato S, Tomomori-Sato C, Banks CA, ''et al.'' |title=Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15123-7 |year= 2003 |pmid= 12584197 |doi= 10.1074/jbc.C300054200 }}
* {{cite journal | vauthors = Pavri R, Lewis B, Kim TK, Dilworth FJ, Erdjument-Bromage H, Tempst P, de Murcia G, Evans R, Chambon P, Reinberg D | title = PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator | journal = Mol. Cell | volume = 18 | issue = 1 | pages = 83–96 | year = 2005 | pmid = 15808511 | doi = 10.1016/j.molcel.2005.02.034 }}
*{{cite journal | author=Sato S, Tomomori-Sato C, Banks CA, ''et al.'' |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671-4 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200 }}
*{{cite journal | author=Tomomori-Sato C, Sato S, Parmely TJ, ''et al.'' |title=A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5846-51 |year= 2004 |pmid= 14638676 |doi= 10.1074/jbc.M312523200 }}
*{{cite journal  | author=Yang F, DeBeaumont R, Zhou S, Näär AM |title=The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2339-44 |year= 2004 |pmid= 14983011 |doi=  }}
*{{cite journal  | author=Sato S, Tomomori-Sato C, Parmely TJ, ''et al.'' |title=A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. |journal=Mol. Cell |volume=14 |issue= 5 |pages= 685-91 |year= 2004 |pmid= 15175163 |doi= 10.1016/j.molcel.2004.05.006 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Pavri R, Lewis B, Kim TK, ''et al.'' |title=PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. |journal=Mol. Cell |volume=18 |issue= 1 |pages= 83-96 |year= 2005 |pmid= 15808511 |doi= 10.1016/j.molcel.2005.02.034 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{UCSC genome browser|MED6}}
* {{UCSC gene details|MED6}}
 
{{InterPro content|IPR007018}}
 
[[Category:Protein families]]
 
 
{{gene-14-stub}}

Latest revision as of 06:21, 4 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human
Med6
Identifiers
SymbolMed6
PfamPF04934
InterProIPR007018

Mediator of RNA polymerase II transcription subunit 6 is one of the subunits of the Mediator complex. It is an enzyme that in humans is encoded by the MED6 gene.[1][2][3]

Protein family

This family of proteins represent the transcriptional mediator protein subunit 6 that is required for activation of many RNA polymerase II promoters and which are conserved from yeast to humans.[1]

Interactions

MED6 has been shown to interact with:

References

  1. ↑ 1.0 1.1 Lee YC, Min S, Gim BS, Kim YJ (August 1997). "A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans". Mol. Cell. Biol. 17 (8): 4622–32. PMC 232315. PMID 9234719.
  2. ↑ Jiang YW, Veschambre P, Erdjument-Bromage H, Tempst P, Conaway JW, Conaway RC, Kornberg RD (Aug 1998). "Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways". Proc Natl Acad Sci U S A. 95 (15): 8538–8543. doi:10.1073/pnas.95.15.8538. PMC 21111. PMID 9671713.
  3. ↑ "Entrez Gene: MED6 mediator of RNA polymerase II transcription, subunit 6 homolog (S. cerevisiae)".
  4. ↑ Yang F, DeBeaumont R, Zhou S, Näär AM (Feb 2004). "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2339–44. doi:10.1073/pnas.0308676100. PMC 356952. PMID 14983011.
  5. ↑ Wang G, Cantin GT, Stevens JL, Berk AJ (Jul 2001). "Characterization of mediator complexes from HeLa cell nuclear extract". Mol. Cell. Biol. 21 (14): 4604–13. doi:10.1128/MCB.21.14.4604-4613.2001. PMC 87123. PMID 11416138.
  6. ↑ 6.0 6.1 Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell. 3 (3): 361–70. doi:10.1016/s1097-2765(00)80463-3. PMID 10198638.
  7. ↑ 7.0 7.1 Kang YK, Guermah M, Yuan CX, Roeder RG (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2642–7. doi:10.1073/pnas.261715899. PMC 122401. PMID 11867769.
  8. ↑ Sun X, Zhang Y, Cho H, Rickert P, Lees E, Lane W, Reinberg D (Aug 1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell. 2 (2): 213–22. doi:10.1016/s1097-2765(00)80131-8. PMID 9734358.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Sun X, Zhang Y, Cho H, Rickert P, Lees E, Lane W, Reinberg D (1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell. 2 (2): 213–222. doi:10.1016/S1097-2765(00)80131-8. PMID 9734358.
  • Gu W, Malik S, Ito M, Yuan CX, Fondell JD, Zhang X, Martinez E, Qin J, Roeder RG (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation". Mol. Cell. 3 (1): 97–108. doi:10.1016/S1097-2765(00)80178-1. PMID 10024883.
  • Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell. 3 (3): 361–370. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
  • Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, Erdjument-Bromage H, Tempst P, Freedman LP (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–828. doi:10.1038/19783. PMID 10235266.
  • Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–832. doi:10.1038/19789. PMID 10235267.
  • Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–464. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
  • Ge K, Guermah M, Yuan CX, Ito M, Wallberg AE, Spiegelman BM, Roeder RG (2002). "Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis". Nature. 417 (6888): 563–567. doi:10.1038/417563a. PMID 12037571.
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External links

This article incorporates text from the public domain Pfam and InterPro: IPR007018


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