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{{Infobox_gene}}
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'''Mediator of RNA polymerase II transcription subunit 14''' is an [[enzyme]] that in humans is encoded by the ''MED14'' [[gene]].<ref name="pmid9989412">{{cite journal |vauthors=Ryu S, Zhou S, Ladurner AG, Tjian R | title = The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1 | journal = Nature | volume = 397 | issue = 6718 | pages = 446–50 |date=Feb 1999 | pmid = 9989412 | pmc =  | doi = 10.1038/17141 }}</ref><ref name="pmid9598311">{{cite journal |vauthors=Yoshikawa H, Fujiyama A, Nakai K, Inazawa J, Matsubara K | title = Detection and isolation of a novel human gene located on Xp11.2-p11.4 that escapes X-inactivation using a two-dimensional DNA mapping method | journal = Genomics | volume = 49 | issue = 2 | pages = 237–46 |date=Aug 1998 | pmid = 9598311 | pmc =  | doi = 10.1006/geno.1998.5246 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CRSP2 cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9282| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa
| HGNCid = 2370
| Symbol = CRSP2
| AltSymbols =; CSRP; CRSP150; CXorf4; DRIP150; EXLM1; MED14; MGC104513; RGR1; TRAP170
| OMIM = 300182
| ECnumber = 
| Homologene = 22082
| MGIid = 1349442
| GeneAtlas_image1 = PBB_GE_CRSP2_202611_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CRSP2_202610_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_CRSP2_202612_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016455 |text = RNA polymerase II transcription mediator activity}} {{GNF_GO|id=GO:0030374 |text = ligand-dependent nuclear receptor transcription coactivator activity}} {{GNF_GO|id=GO:0042809 |text = vitamin D receptor binding}} {{GNF_GO|id=GO:0046966 |text = thyroid hormone receptor binding}}
| Component = {{GNF_GO|id=GO:0000119 |text = mediator complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
  | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006367 |text = transcription initiation from RNA polymerase II promoter}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9282
    | Hs_Ensembl = ENSG00000180182
    | Hs_RefseqProtein = XP_001126052
    | Hs_RefseqmRNA = XM_001126052
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 40392502
    | Hs_GenLoc_end = 40479727
    | Hs_Uniprot = O60244
    | Mm_EntrezGene = 26896
    | Mm_Ensembl = ENSMUSG00000064127
    | Mm_RefseqmRNA = NM_001048208
    | Mm_RefseqProtein = NP_001041673
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 11836708
    | Mm_GenLoc_end = 11919032
    | Mm_Uniprot = 
  }}
}}
'''Cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa''', also known as '''CRSP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CRSP2 cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9282| accessdate = }}</ref>


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{{PBB_Summary
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| section_title =  
| section_title =  
| summary_text = The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.<ref name="entrez">{{cite web | title = Entrez Gene: CRSP2 cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9282| accessdate = }}</ref>
| summary_text = The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.<ref name="entrez" />
}}
}}
==Interactions==
MED14 has been shown to [[Protein-protein interaction|interact]] with [[PPARGC1A]],<ref name=pmid14636573>{{cite journal |last=Wallberg |first=Annika E |authorlink= |author2=Yamamura Soichiro |author3=Malik Sohail |author4=Spiegelman Bruce M |author5=Roeder Robert G  |date=Nov 2003 |title=Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha |journal=Mol. Cell |volume=12 |issue=5 |pages=1137–49 |publisher= |location = United States| issn = 1097-2765| pmid = 14636573 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S1097-2765(03)00391-5 }}</ref> [[Estrogen receptor alpha]],<ref name=pmid11867769>{{cite journal |last=Kang |first=Yun Kyoung |authorlink= |author2=Guermah Mohamed |author3=Yuan Chao-Xing |author4=Roeder Robert G  |date=Mar 2002 |title=The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=99 |issue=5 |pages=2642–7 |publisher= |location = United States| issn = 0027-8424| pmid = 11867769 |doi = 10.1073/pnas.261715899 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=122401 }}</ref> [[STAT2]],<ref name=pmid12509459>{{cite journal |last=Lau |first=Joe F |authorlink= |author2=Nusinzon Inna |author3=Burakov Darya |author4=Freedman Leonard P |author5=Horvath Curt M  |date=Jan 2003 |title=Role of metazoan mediator proteins in interferon-responsive transcription |journal=Mol. Cell. Biol. |volume=23 |issue=2 |pages=620–8 |publisher= |location = United States| issn = 0270-7306| pmid = 12509459 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/MCB.23.2.620-628.2003 |pmc=151539 }}</ref> [[Cyclin-dependent kinase 8]],<ref name=pmid11416138>{{cite journal |last=Wang |first=G |authorlink= |author2=Cantin G T |author3=Stevens J L |author4=Berk A J  |date=Jul 2001 |title=Characterization of mediator complexes from HeLa cell nuclear extract |journal=Mol. Cell. Biol. |volume=21 |issue=14 |pages=4604–13 |publisher= |location = United States| issn = 0270-7306| pmid = 11416138 |doi = 10.1128/MCB.21.14.4604-4613.2001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=87123 }}</ref><ref name=pmid10198638>{{cite journal |last=Ito |first=M |authorlink= |author2=Yuan C X |author3=Malik S |author4=Gu W |author5=Fondell J D |author6=Yamamura S |author7=Fu Z Y |author8=Zhang X |author9=Qin J |author10=Roeder R G  |date=Mar 1999 |title=Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators |journal=Mol. Cell |volume=3 |issue=3 |pages=361–70 |publisher= |location = UNITED STATES| issn = 1097-2765| pmid = 10198638 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S1097-2765(00)80463-3 }}</ref> [[Glucocorticoid receptor]]<ref name=pmid10508170>{{cite journal |last=Hittelman |first=A B |authorlink= |author2=Burakov D |author3=Iñiguez-Lluhí J A |author4=Freedman L P |author5=Garabedian M J  |date=Oct 1999 |title=Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins |journal=EMBO J. |volume=18 |issue=19 |pages=5380–8 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 10508170 |doi = 10.1093/emboj/18.19.5380 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1171607 }}</ref> and [[Hepatocyte nuclear factor 4 alpha]].<ref name=pmid12089346>{{cite journal |last=Maeda |first=Yutaka |authorlink= |author2=Rachez Christophe |author3=Hawel Leo |author4=Byus Craig V |author5=Freedman Leonard P |author6=Sladek Frances M  |date=Jul 2002 |title=Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205 |journal=Mol. Endocrinol. |volume=16 |issue=7 |pages=1502–10 |publisher= |location = United States| issn = 0888-8809| pmid = 12089346 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1210/mend.16.7.0883 }}</ref><ref name=pmid12101254>{{cite journal |last=Malik |first=Sohail |authorlink= |author2=Wallberg Annika E |author3=Kang Yun Kyoung |author4=Roeder Robert G  |date=Aug 2002 |title=TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4 |journal=Mol. Cell. Biol. |volume=22 |issue=15 |pages=5626–37 |publisher= |location = United States| issn = 0270-7306| pmid = 12101254 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/MCB.22.15.5626-5637.2002 |pmc=133960 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
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| citations =  
| citations =  
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | author=Andersson B |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138  |name-list-format=vanc| author2=Wentland MA  | author3=Ricafrente JY  | display-authors=3  | last4=Liu  | first4=W  | last5=Gibbs  | first5=RA }}
*{{cite journal | author=Fondell JD, Ge H, Roeder RG |title=Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 16 |pages= 8329-33 |year= 1996 |pmid= 8710870 |doi=  }}
*{{cite journal  |vauthors=Fondell JD, Ge H, Roeder RG |title=Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 16 |pages= 8329–33 |year= 1996 |pmid= 8710870 |doi=10.1073/pnas.93.16.8329  | pmc=38670  }}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
*{{cite journal  | author=Yu W |title=Large-scale concatenation cDNA sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 |name-list-format=vanc| author2=Andersson B  | author3=Worley KC  | display-authors=3  | last4=Muzny  | first4=DM  | last5=Ding  | first5=Y  | last6=Liu  | first6=W  | last7=Ricafrente  | first7=JY  | last8=Wentland  | first8=MA  | last9=Lennon  | first9=G }}
*{{cite journal  | author=Yoshikawa H, Fujiyama A, Nakai K, ''et al.'' |title=Detection and isolation of a novel human gene located on Xp11.2-p11.4 that escapes X-inactivation using a two-dimensional DNA mapping method. |journal=Genomics |volume=49 |issue= 2 |pages= 237-46 |year= 1998 |pmid= 9598311 |doi= 10.1006/geno.1998.5246 }}
*{{cite journal  | author=Sun X |title=NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription |journal=Mol. Cell |volume=2 |issue= 2 |pages= 213–22 |year= 1998 |pmid= 9734358 |doi=10.1016/S1097-2765(00)80131-8 |name-list-format=vanc| author2=Zhang Y  | author3=Cho H  | display-authors=3  | last4=Rickert  | first4=Paula  | last5=Lees  | first5=Emma  | last6=Lane  | first6=William  | last7=Reinberg  | first7=Danny }}
*{{cite journal | author=Sun X, Zhang Y, Cho H, ''et al.'' |title=NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. |journal=Mol. Cell |volume=2 |issue= 2 |pages= 213-22 |year= 1998 |pmid= 9734358 |doi=  }}
*{{cite journal  | author=Gu W |title=A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation |journal=Mol. Cell |volume=3 |issue= 1 |pages= 97–108 |year= 1999 |pmid= 10024883 |doi=10.1016/S1097-2765(00)80178-1 |name-list-format=vanc| author2=Malik S  | author3=Ito M  | display-authors=3  | last4=Yuan  | first4=Chao-Xing  | last5=Fondell  | first5=Joseph D  | last6=Zhang  | first6=Xiaolong  | last7=Martinez  | first7=Ernest  | last8=Qin  | first8=Jun  | last9=Roeder  | first9=Robert G  }}
*{{cite journal  | author=Ryu S, Zhou S, Ladurner AG, Tjian R |title=The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. |journal=Nature |volume=397 |issue= 6718 |pages= 446-50 |year= 1999 |pmid= 9989412 |doi= 10.1038/17141 }}
*{{cite journal  | author=Ito M |title=Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators |journal=Mol. Cell |volume=3 |issue= 3 |pages= 361–70 |year= 1999 |pmid= 10198638 |doi=10.1016/S1097-2765(00)80463-3 |name-list-format=vanc| author2=Yuan CX  | author3=Malik S  | display-authors=3  | last4=Gu  | first4=Wei  | last5=Fondell  | first5=Joseph D  | last6=Yamamura  | first6=Soichiro  | last7=Fu  | first7=Zheng-Yuan  | last8=Zhang  | first8=Xiaolong  | last9=Qin  | first9=Jun  }}
*{{cite journal | author=Gu W, Malik S, Ito M, ''et al.'' |title=A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. |journal=Mol. Cell |volume=3 |issue= 1 |pages= 97-108 |year= 1999 |pmid= 10024883 |doi=  }}
*{{cite journal  | author=Rachez C |title=Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex |journal=Nature |volume=398 |issue= 6730 |pages= 824–8 |year= 1999 |pmid= 10235266 |doi= 10.1038/19783 |name-list-format=vanc| author2=Lemon BD  | author3=Suldan Z  | display-authors=3  | last4=Suldan  | first4=Zalman  | last5=Bromleigh  | first5=Virginia  | last6=Gamble  | first6=Matthew | last7=Näär  | first7=Anders M.  | last8=Erdjument-Bromage  | first8=Hediye  | last9=Tempst  | first9=Paul }}
*{{cite journal  | author=Ito M, Yuan CX, Malik S, ''et al.'' |title=Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. |journal=Mol. Cell |volume=3 |issue= 3 |pages= 361-70 |year= 1999 |pmid= 10198638 |doi=  }}
*{{cite journal  | author=Näär AM |title=Composite co-activator ARC mediates chromatin-directed transcriptional activation |journal=Nature |volume=398 |issue= 6730 |pages= 828–32 |year= 1999 |pmid= 10235267 |doi= 10.1038/19789 |name-list-format=vanc| author2=Beaurang PA  | author3=Zhou S  | display-authors=3  | last4=Zhou  | first4=Sharleen  | last5=Abraham  | first5=Shaji  | last6=Solomon  | first6=William }}
*{{cite journal  | author=Rachez C, Lemon BD, Suldan Z, ''et al.'' |title=Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. |journal=Nature |volume=398 |issue= 6730 |pages= 824-8 |year= 1999 |pmid= 10235266 |doi= 10.1038/19783 }}
*{{cite journal  | author=Hittelman AB |title=Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins |journal=EMBO J. |volume=18 |issue= 19 |pages= 5380–8 |year= 1999 |pmid= 10508170 |doi= 10.1093/emboj/18.19.5380 | pmc=1171607 |name-list-format=vanc| author2=Burakov D  | author3=Iñiguez-Lluhí JA  | display-authors=3  | last4=Freedman  | first4=LP  | last5=Garabedian  | first5=MJ }}
*{{cite journal  | author=Näär AM, Beaurang PA, Zhou S, ''et al.'' |title=Composite co-activator ARC mediates chromatin-directed transcriptional activation. |journal=Nature |volume=398 |issue= 6730 |pages= 828-32 |year= 1999 |pmid= 10235267 |doi= 10.1038/19789 }}
*{{cite journal  | author=Ge K |title=Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis |journal=Nature |volume=417 |issue= 6888 |pages= 563–7 |year= 2002 |pmid= 12037571 |doi= 10.1038/417563a |name-list-format=vanc| author2=Guermah M | author3=Yuan CX  | display-authors=3  | last4=Ito  | first4=Mitsuhiro  | last5=Wallberg  | first5=Annika E.  | last6=Spiegelman  | first6=Bruce M.  | last7=Roeder  | first7=Robert G. }}
*{{cite journal | author=Hittelman AB, Burakov D, Iñiguez-Lluhí JA, ''et al.'' |title=Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins. |journal=EMBO J. |volume=18 |issue= 19 |pages= 5380-8 |year= 1999 |pmid= 10508170 |doi= 10.1093/emboj/18.19.5380 }}
*{{cite journal  |vauthors=Malik S, Wallberg AE, Kang YK, Roeder RG |title=TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4 |journal=Mol. Cell. Biol. |volume=22 |issue= 15 |pages= 5626–37 |year= 2002 |pmid= 12101254 |doi=10.1128/MCB.22.15.5626-5637.2002  | pmc=133960  }}
*{{cite journal  | author=Ge K, Guermah M, Yuan CX, ''et al.'' |title=Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. |journal=Nature |volume=417 |issue= 6888 |pages= 563-7 |year= 2002 |pmid= 12037571 |doi= 10.1038/417563a }}
*{{cite journal  |vauthors=Wang Q, Sharma D, Ren Y, Fondell JD |title=A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42852–8 |year= 2003 |pmid= 12218053 |doi= 10.1074/jbc.M206061200 }}
*{{cite journal | author=Malik S, Wallberg AE, Kang YK, Roeder RG |title=TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4. |journal=Mol. Cell. Biol. |volume=22 |issue= 15 |pages= 5626-37 |year= 2002 |pmid= 12101254 |doi= }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal | author=Wang Q, Sharma D, Ren Y, Fondell JD |title=A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42852-8 |year= 2003 |pmid= 12218053 |doi= 10.1074/jbc.M206061200 }}
*{{cite journal  | author=Lau JF |title=Role of metazoan mediator proteins in interferon-responsive transcription |journal=Mol. Cell. Biol. |volume=23 |issue= 2 |pages= 620–8 |year= 2003 |pmid= 12509459 |doi=10.1128/MCB.23.2.620-628.2003  | pmc=151539  |name-list-format=vanc| author2=Nusinzon I  | author3=Burakov D  | display-authors=3  | last4=Freedman  | first4=L. P.  | last5=Horvath  | first5=C. M.  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Demirci FY |title=Refinement of the physical location and the genomic characterization of the CRSP2 (EXLM1) gene on Xp11.4 |journal=DNA Seq. |volume=14 |issue= 2 |pages= 123–7 |year= 2004 |pmid= 12825353 |doi=  10.1080/1042517021000056952|name-list-format=vanc| author2=Ramser J  | author3=White NJ  | display-authors=3  | last4=Rigatti  | first4=BW  | last5=Meindl  | first5=A  | last6=Lewis  | first6=KF  | last7=Wen  | first7=G  | last8=Gorin  | first8=MB  }}
*{{cite journal | author=Lau JF, Nusinzon I, Burakov D, ''et al.'' |title=Role of metazoan mediator proteins in interferon-responsive transcription. |journal=Mol. Cell. Biol. |volume=23 |issue= 2 |pages= 620-8 |year= 2003 |pmid= 12509459 |doi=  }}
*{{cite journal  | author=Sato S |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671–4 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200  |name-list-format=vanc| author2=Tomomori-Sato C  | author3=Banks CA  | display-authors=3  | last4=Parmely  | first4=TJ  | last5=Sorokina  | first5=I  | last6=Brower  | first6=CS  | last7=Conaway  | first7=RC  | last8=Conaway  | first8=JW }}
*{{cite journal  | author=Demirci FY, Ramser J, White NJ, ''et al.'' |title=Refinement of the physical location and the genomic characterization of the CRSP2 (EXLM1) gene on Xp11.4. |journal=DNA Seq. |volume=14 |issue= 2 |pages= 123-7 |year= 2004 |pmid= 12825353 |doi=  }}
*{{cite journal  | author=Wallberg AE |title=Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha |journal=Mol. Cell |volume=12 |issue= 5 |pages= 1137–49 |year= 2004 |pmid= 14636573 |doi=10.1016/S1097-2765(03)00391-5  |name-list-format=vanc| author2=Yamamura S  | author3=Malik S  | display-authors=3  | last4=Spiegelman  | first4=Bruce M  | last5=Roeder  | first5=Robert G  }}
*{{cite journal | author=Sato S, Tomomori-Sato C, Banks CA, ''et al.'' |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671-4 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200 }}
*{{cite journal  | author=Tomomori-Sato C |title=A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5846–51 |year= 2004 |pmid= 14638676 |doi= 10.1074/jbc.M312523200 |name-list-format=vanc| author2=Sato S  | author3=Parmely TJ  | display-authors=3  | last4=Banks  | first4=CA  | last5=Sorokina  | first5=I  | last6=Florens  | first6=L  | last7=Zybailov  | first7=B  | last8=Washburn  | first8=MP  | last9=Brower  | first9=CS }}
*{{cite journal  | author=Wallberg AE, Yamamura S, Malik S, ''et al.'' |title=Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. |journal=Mol. Cell |volume=12 |issue= 5 |pages= 1137-49 |year= 2004 |pmid= 14636573 |doi=  }}
*{{cite journal | author=Tomomori-Sato C, Sato S, Parmely TJ, ''et al.'' |title=A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5846-51 |year= 2004 |pmid= 14638676 |doi= 10.1074/jbc.M312523200 }}
}}
}}
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Revision as of 06:20, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Wikidata
View/Edit Human

Mediator of RNA polymerase II transcription subunit 14 is an enzyme that in humans is encoded by the MED14 gene.[1][2][3]

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.[3]

Interactions

MED14 has been shown to interact with PPARGC1A,[4] Estrogen receptor alpha,[5] STAT2,[6] Cyclin-dependent kinase 8,[7][8] Glucocorticoid receptor[9] and Hepatocyte nuclear factor 4 alpha.[10][11]

References

  1. ↑ Ryu S, Zhou S, Ladurner AG, Tjian R (Feb 1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature. 397 (6718): 446–50. doi:10.1038/17141. PMID 9989412.
  2. ↑ Yoshikawa H, Fujiyama A, Nakai K, Inazawa J, Matsubara K (Aug 1998). "Detection and isolation of a novel human gene located on Xp11.2-p11.4 that escapes X-inactivation using a two-dimensional DNA mapping method". Genomics. 49 (2): 237–46. doi:10.1006/geno.1998.5246. PMID 9598311.
  3. ↑ 3.0 3.1 "Entrez Gene: CRSP2 cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa".
  4. ↑ Wallberg, Annika E; Yamamura Soichiro; Malik Sohail; Spiegelman Bruce M; Roeder Robert G (Nov 2003). "Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha". Mol. Cell. United States. 12 (5): 1137–49. doi:10.1016/S1097-2765(03)00391-5. ISSN 1097-2765. PMID 14636573.
  5. ↑ Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. United States. 99 (5): 2642–7. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769.
  6. ↑ Lau, Joe F; Nusinzon Inna; Burakov Darya; Freedman Leonard P; Horvath Curt M (Jan 2003). "Role of metazoan mediator proteins in interferon-responsive transcription". Mol. Cell. Biol. United States. 23 (2): 620–8. doi:10.1128/MCB.23.2.620-628.2003. ISSN 0270-7306. PMC 151539. PMID 12509459.
  7. ↑ Wang, G; Cantin G T; Stevens J L; Berk A J (Jul 2001). "Characterization of mediator complexes from HeLa cell nuclear extract". Mol. Cell. Biol. United States. 21 (14): 4604–13. doi:10.1128/MCB.21.14.4604-4613.2001. ISSN 0270-7306. PMC 87123. PMID 11416138.
  8. ↑ Ito, M; Yuan C X; Malik S; Gu W; Fondell J D; Yamamura S; Fu Z Y; Zhang X; Qin J; Roeder R G (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell. UNITED STATES. 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. ISSN 1097-2765. PMID 10198638.
  9. ↑ Hittelman, A B; Burakov D; Iñiguez-Lluhí J A; Freedman L P; Garabedian M J (Oct 1999). "Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins". EMBO J. ENGLAND. 18 (19): 5380–8. doi:10.1093/emboj/18.19.5380. ISSN 0261-4189. PMC 1171607. PMID 10508170.
  10. ↑ Maeda, Yutaka; Rachez Christophe; Hawel Leo; Byus Craig V; Freedman Leonard P; Sladek Frances M (Jul 2002). "Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205". Mol. Endocrinol. United States. 16 (7): 1502–10. doi:10.1210/mend.16.7.0883. ISSN 0888-8809. PMID 12089346.
  11. ↑ Malik, Sohail; Wallberg Annika E; Kang Yun Kyoung; Roeder Robert G (Aug 2002). "TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4". Mol. Cell. Biol. United States. 22 (15): 5626–37. doi:10.1128/MCB.22.15.5626-5637.2002. ISSN 0270-7306. PMC 133960. PMID 12101254.

Further reading


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