MED14: Difference between revisions

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{{Infobox_gene}}
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'''Mediator of RNA polymerase II transcription subunit 14''' is an [[enzyme]] that in humans is encoded by the ''MED14'' [[gene]].<ref name="pmid9989412">{{cite journal |vauthors=Ryu S, Zhou S, Ladurner AG, Tjian R | title = The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1 | journal = Nature | volume = 397 | issue = 6718 | pages = 446–50 |date=Feb 1999 | pmid = 9989412 | pmc =  | doi = 10.1038/17141 | bibcode =1999Natur.397..446R }}</ref><ref name="pmid9598311">{{cite journal |vauthors=Yoshikawa H, Fujiyama A, Nakai K, Inazawa J, Matsubara K | title = Detection and isolation of a novel human gene located on Xp11.2-p11.4 that escapes X-inactivation using a two-dimensional DNA mapping method | journal = Genomics | volume = 49 | issue = 2 | pages = 237–46 |date=Aug 1998 | pmid = 9598311 | pmc =  | doi = 10.1006/geno.1998.5246 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CRSP2 cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9282| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa
| HGNCid = 2370
| Symbol = CRSP2
| AltSymbols =; CSRP; CRSP150; CXorf4; DRIP150; EXLM1; MED14; MGC104513; RGR1; TRAP170
| OMIM = 300182
| ECnumber =
| Homologene = 22082
| MGIid = 1349442
  | GeneAtlas_image1 = PBB_GE_CRSP2_202611_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CRSP2_202610_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_CRSP2_202612_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016455 |text = RNA polymerase II transcription mediator activity}} {{GNF_GO|id=GO:0030374 |text = ligand-dependent nuclear receptor transcription coactivator activity}} {{GNF_GO|id=GO:0042809 |text = vitamin D receptor binding}} {{GNF_GO|id=GO:0046966 |text = thyroid hormone receptor binding}}
| Component = {{GNF_GO|id=GO:0000119 |text = mediator complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006367 |text = transcription initiation from RNA polymerase II promoter}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9282
    | Hs_Ensembl = ENSG00000180182
    | Hs_RefseqProtein = XP_001126052
    | Hs_RefseqmRNA = XM_001126052
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 40392502
    | Hs_GenLoc_end = 40479727
    | Hs_Uniprot = O60244
    | Mm_EntrezGene = 26896
    | Mm_Ensembl = ENSMUSG00000064127
    | Mm_RefseqmRNA = NM_001048208
    | Mm_RefseqProtein = NP_001041673
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 11836708
    | Mm_GenLoc_end = 11919032
    | Mm_Uniprot = 
  }}
}}
'''Cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa''', also known as '''CRSP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CRSP2 cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9282| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.<ref name="entrez">{{cite web | title = Entrez Gene: CRSP2 cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9282| accessdate = }}</ref>
| summary_text = The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.<ref name="entrez" />
}}
}}
==Interactions==
MED14 has been shown to [[Protein-protein interaction|interact]] with [[PPARGC1A]],<ref name=pmid14636573>{{cite journal |last=Wallberg |first=Annika E |authorlink= |author2=Yamamura Soichiro |author3=Malik Sohail |author4=Spiegelman Bruce M |author5=Roeder Robert G  |date=Nov 2003 |title=Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha |journal=Mol. Cell |volume=12 |issue=5 |pages=1137–49 | issn = 1097-2765| pmid = 14636573 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S1097-2765(03)00391-5 }}</ref> [[Estrogen receptor alpha]],<ref name=pmid11867769>{{cite journal |last=Kang |first=Yun Kyoung |authorlink= |author2=Guermah Mohamed |author3=Yuan Chao-Xing |author4=Roeder Robert G  |date=Mar 2002 |title=The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=99 |issue=5 |pages=2642–7 | issn = 0027-8424| pmid = 11867769 |doi = 10.1073/pnas.261715899 | bibcode =2002PNAS...99.2642K | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=122401 }}</ref> [[STAT2]],<ref name=pmid12509459>{{cite journal |last=Lau |first=Joe F |authorlink= |author2=Nusinzon Inna |author3=Burakov Darya |author4=Freedman Leonard P |author5=Horvath Curt M  |date=Jan 2003 |title=Role of metazoan mediator proteins in interferon-responsive transcription |journal=Mol. Cell. Biol. |volume=23 |issue=2 |pages=620–8 | issn = 0270-7306| pmid = 12509459 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/MCB.23.2.620-628.2003 |pmc=151539 }}</ref> [[Cyclin-dependent kinase 8]],<ref name=pmid11416138>{{cite journal |last=Wang |first=G |authorlink= |author2=Cantin G T |author3=Stevens J L |author4=Berk A J  |date=Jul 2001 |title=Characterization of mediator complexes from HeLa cell nuclear extract |journal=Mol. Cell. Biol. |volume=21 |issue=14 |pages=4604–13 | issn = 0270-7306| pmid = 11416138 |doi = 10.1128/MCB.21.14.4604-4613.2001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=87123 }}</ref><ref name=pmid10198638>{{cite journal |last=Ito |first=M |authorlink= |author2=Yuan C X |author3=Malik S |author4=Gu W |author5=Fondell J D |author6=Yamamura S |author7=Fu Z Y |author8=Zhang X |author9=Qin J |author10=Roeder R G  |date=Mar 1999 |title=Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators |journal=Mol. Cell |volume=3 |issue=3 |pages=361–70 | issn = 1097-2765| pmid = 10198638 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S1097-2765(00)80463-3 }}</ref> [[Glucocorticoid receptor]]<ref name=pmid10508170>{{cite journal |last=Hittelman |first=A B |authorlink= |author2=Burakov D |author3=Iñiguez-Lluhí J A |author4=Freedman L P |author5=Garabedian M J  |date=Oct 1999 |title=Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins |journal=EMBO J. |volume=18 |issue=19 |pages=5380–8 | issn = 0261-4189| pmid = 10508170 |doi = 10.1093/emboj/18.19.5380 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1171607 }}</ref> and [[Hepatocyte nuclear factor 4 alpha]].<ref name=pmid12089346>{{cite journal |last=Maeda |first=Yutaka |authorlink= |author2=Rachez Christophe |author3=Hawel Leo |author4=Byus Craig V |author5=Freedman Leonard P |author6=Sladek Frances M  |date=Jul 2002 |title=Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205 |journal=Mol. Endocrinol. |volume=16 |issue=7 |pages=1502–10 | issn = 0888-8809| pmid = 12089346 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1210/mend.16.7.0883 }}</ref><ref name=pmid12101254>{{cite journal |last=Malik |first=Sohail |authorlink= |author2=Wallberg Annika E |author3=Kang Yun Kyoung |author4=Roeder Robert G  |date=Aug 2002 |title=TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4 |journal=Mol. Cell. Biol. |volume=22 |issue=15 |pages=5626–37 | issn = 0270-7306| pmid = 12101254 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/MCB.22.15.5626-5637.2002 |pmc=133960 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | author=Andersson B |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138  |name-list-format=vanc| author2=Wentland MA  | author3=Ricafrente JY  | display-authors=3  | last4=Liu  | first4=W  | last5=Gibbs  | first5=RA }}
*{{cite journal | author=Fondell JD, Ge H, Roeder RG |title=Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 16 |pages= 8329-33 |year= 1996 |pmid= 8710870 |doi=  }}
*{{cite journal  |vauthors=Fondell JD, Ge H, Roeder RG |title=Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 16 |pages= 8329–33 |year= 1996 |pmid= 8710870 |doi=10.1073/pnas.93.16.8329  | pmc=38670  |bibcode=1996PNAS...93.8329F }}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
*{{cite journal  | author=Yu W |title=Large-scale concatenation cDNA sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 |name-list-format=vanc| author2=Andersson B  | author3=Worley KC  | display-authors=3  | last4=Muzny  | first4=DM  | last5=Ding  | first5=Y  | last6=Liu  | first6=W | last7=Ricafrente  | first7=JY  | last8=Wentland  | first8=MA  | last9=Lennon  | first9=G  }}
*{{cite journal  | author=Yoshikawa H, Fujiyama A, Nakai K, ''et al.'' |title=Detection and isolation of a novel human gene located on Xp11.2-p11.4 that escapes X-inactivation using a two-dimensional DNA mapping method. |journal=Genomics |volume=49 |issue= 2 |pages= 237-46 |year= 1998 |pmid= 9598311 |doi= 10.1006/geno.1998.5246 }}
*{{cite journal  | author=Sun X |title=NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription |journal=Mol. Cell |volume=2 |issue= 2 |pages= 213–22 |year= 1998 |pmid= 9734358 |doi=10.1016/S1097-2765(00)80131-8 |name-list-format=vanc| author2=Zhang Y  | author3=Cho H  | display-authors=3  | last4=Rickert  | first4=Paula  | last5=Lees  | first5=Emma  | last6=Lane  | first6=William  | last7=Reinberg  | first7=Danny }}
*{{cite journal | author=Sun X, Zhang Y, Cho H, ''et al.'' |title=NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. |journal=Mol. Cell |volume=2 |issue= 2 |pages= 213-22 |year= 1998 |pmid= 9734358 |doi=  }}
*{{cite journal  | author=Gu W |title=A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation |journal=Mol. Cell |volume=3 |issue= 1 |pages= 97–108 |year= 1999 |pmid= 10024883 |doi=10.1016/S1097-2765(00)80178-1 |name-list-format=vanc| author2=Malik S | author3=Ito M  | display-authors=3  | last4=Yuan  | first4=Chao-Xing  | last5=Fondell  | first5=Joseph D  | last6=Zhang  | first6=Xiaolong  | last7=Martinez  | first7=Ernest  | last8=Qin  | first8=Jun  | last9=Roeder  | first9=Robert G  }}
*{{cite journal  | author=Ryu S, Zhou S, Ladurner AG, Tjian R |title=The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. |journal=Nature |volume=397 |issue= 6718 |pages= 446-50 |year= 1999 |pmid= 9989412 |doi= 10.1038/17141 }}
*{{cite journal  | author=Ito M |title=Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators |journal=Mol. Cell |volume=3 |issue= 3 |pages= 361–70 |year= 1999 |pmid= 10198638 |doi=10.1016/S1097-2765(00)80463-3 |name-list-format=vanc| author2=Yuan CX  | author3=Malik S  | display-authors=3  | last4=Gu  | first4=Wei  | last5=Fondell  | first5=Joseph D  | last6=Yamamura  | first6=Soichiro  | last7=Fu  | first7=Zheng-Yuan  | last8=Zhang  | first8=Xiaolong  | last9=Qin  | first9=Jun  }}
*{{cite journal | author=Gu W, Malik S, Ito M, ''et al.'' |title=A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. |journal=Mol. Cell |volume=3 |issue= 1 |pages= 97-108 |year= 1999 |pmid= 10024883 |doi=  }}
*{{cite journal  | author=Rachez C |title=Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex |journal=Nature |volume=398 |issue= 6730 |pages= 824–8 |year= 1999 |pmid= 10235266 |doi= 10.1038/19783 |name-list-format=vanc| author2=Lemon BD  | author3=Suldan Z  | display-authors=3  | last4=Suldan  | first4=Zalman  | last5=Bromleigh  | first5=Virginia  | last6=Gamble  | first6=Matthew  | last7=Näär | first7=Anders M.  | last8=Erdjument-Bromage  | first8=Hediye  | last9=Tempst  | first9=Paul |bibcode=1999Natur.398..824R}}
*{{cite journal  | author=Ito M, Yuan CX, Malik S, ''et al.'' |title=Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. |journal=Mol. Cell |volume=3 |issue= 3 |pages= 361-70 |year= 1999 |pmid= 10198638 |doi=  }}
*{{cite journal  | author=Näär AM |title=Composite co-activator ARC mediates chromatin-directed transcriptional activation |journal=Nature |volume=398 |issue= 6730 |pages= 828–32 |year= 1999 |pmid= 10235267 |doi= 10.1038/19789 |name-list-format=vanc| author2=Beaurang PA  | author3=Zhou S  | display-authors=3  | last4=Zhou  | first4=Sharleen  | last5=Abraham  | first5=Shaji  | last6=Solomon  | first6=William |bibcode=1999Natur.398..828N}}
*{{cite journal | author=Rachez C, Lemon BD, Suldan Z, ''et al.'' |title=Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. |journal=Nature |volume=398 |issue= 6730 |pages= 824-8 |year= 1999 |pmid= 10235266 |doi= 10.1038/19783 }}
*{{cite journal  | author=Hittelman AB |title=Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins |journal=EMBO J. |volume=18 |issue= 19 |pages= 5380–8 |year= 1999 |pmid= 10508170 |doi= 10.1093/emboj/18.19.5380 | pmc=1171607 |name-list-format=vanc| author2=Burakov D  | author3=Iñiguez-Lluhí JA  | display-authors=3  | last4=Freedman  | first4=LP  | last5=Garabedian  | first5=MJ }}
*{{cite journal  | author=Näär AM, Beaurang PA, Zhou S, ''et al.'' |title=Composite co-activator ARC mediates chromatin-directed transcriptional activation. |journal=Nature |volume=398 |issue= 6730 |pages= 828-32 |year= 1999 |pmid= 10235267 |doi= 10.1038/19789 }}
*{{cite journal  | author=Ge K |title=Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis |journal=Nature |volume=417 |issue= 6888 |pages= 563–7 |year= 2002 |pmid= 12037571 |doi= 10.1038/417563a  |name-list-format=vanc| author2=Guermah M | author3=Yuan CX  | display-authors=3  | last4=Ito  | first4=Mitsuhiro  | last5=Wallberg  | first5=Annika E.  | last6=Spiegelman  | first6=Bruce M.  | last7=Roeder | first7=Robert G. |bibcode=2002Natur.417..563G}}
*{{cite journal | author=Hittelman AB, Burakov D, Iñiguez-Lluhí JA, ''et al.'' |title=Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins. |journal=EMBO J. |volume=18 |issue= 19 |pages= 5380-8 |year= 1999 |pmid= 10508170 |doi= 10.1093/emboj/18.19.5380 }}
*{{cite journal  |vauthors=Malik S, Wallberg AE, Kang YK, Roeder RG |title=TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4 |journal=Mol. Cell. Biol. |volume=22 |issue= 15 |pages= 5626–37 |year= 2002 |pmid= 12101254 |doi=10.1128/MCB.22.15.5626-5637.2002  | pmc=133960  }}
*{{cite journal  | author=Ge K, Guermah M, Yuan CX, ''et al.'' |title=Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. |journal=Nature |volume=417 |issue= 6888 |pages= 563-7 |year= 2002 |pmid= 12037571 |doi= 10.1038/417563a }}
*{{cite journal  |vauthors=Wang Q, Sharma D, Ren Y, Fondell JD |title=A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42852–8 |year= 2003 |pmid= 12218053 |doi= 10.1074/jbc.M206061200 }}
*{{cite journal | author=Malik S, Wallberg AE, Kang YK, Roeder RG |title=TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4. |journal=Mol. Cell. Biol. |volume=22 |issue= 15 |pages= 5626-37 |year= 2002 |pmid= 12101254 |doi= }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M}}
*{{cite journal | author=Wang Q, Sharma D, Ren Y, Fondell JD |title=A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42852-8 |year= 2003 |pmid= 12218053 |doi= 10.1074/jbc.M206061200 }}
*{{cite journal  | author=Lau JF |title=Role of metazoan mediator proteins in interferon-responsive transcription |journal=Mol. Cell. Biol. |volume=23 |issue= 2 |pages= 620–8 |year= 2003 |pmid= 12509459 |doi=10.1128/MCB.23.2.620-628.2003  | pmc=151539  |name-list-format=vanc| author2=Nusinzon I  | author3=Burakov D  | display-authors=3  | last4=Freedman  | first4=L. P.  | last5=Horvath  | first5=C. M.  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Demirci FY |title=Refinement of the physical location and the genomic characterization of the CRSP2 (EXLM1) gene on Xp11.4 |journal=DNA Seq. |volume=14 |issue= 2 |pages= 123–7 |year= 2004 |pmid= 12825353 |doi=  10.1080/1042517021000056952|name-list-format=vanc| author2=Ramser J  | author3=White NJ  | display-authors=3  | last4=Rigatti  | first4=BW  | last5=Meindl  | first5=A  | last6=Lewis  | first6=KF  | last7=Wen  | first7=G  | last8=Gorin  | first8=MB  |url=http://www.escholarship.org/uc/item/2t83v1rr |format=Submitted manuscript }}
*{{cite journal  | author=Lau JF, Nusinzon I, Burakov D, ''et al.'' |title=Role of metazoan mediator proteins in interferon-responsive transcription. |journal=Mol. Cell. Biol. |volume=23 |issue= 2 |pages= 620-8 |year= 2003 |pmid= 12509459 |doi=  }}
*{{cite journal  | author=Sato S |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671–4 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200  |name-list-format=vanc| author2=Tomomori-Sato C  | author3=Banks CA  | display-authors=3  | last4=Parmely  | first4=TJ  | last5=Sorokina  | first5=I  | last6=Brower  | first6=CS  | last7=Conaway  | first7=RC  | last8=Conaway  | first8=JW }}
*{{cite journal | author=Demirci FY, Ramser J, White NJ, ''et al.'' |title=Refinement of the physical location and the genomic characterization of the CRSP2 (EXLM1) gene on Xp11.4. |journal=DNA Seq. |volume=14 |issue= 2 |pages= 123-7 |year= 2004 |pmid= 12825353 |doi=  }}
*{{cite journal  | author=Wallberg AE |title=Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha |journal=Mol. Cell |volume=12 |issue= 5 |pages= 1137–49 |year= 2004 |pmid= 14636573 |doi=10.1016/S1097-2765(03)00391-5  |name-list-format=vanc| author2=Yamamura S  | author3=Malik S  | display-authors=3  | last4=Spiegelman  | first4=Bruce M  | last5=Roeder  | first5=Robert G  }}
*{{cite journal  | author=Sato S, Tomomori-Sato C, Banks CA, ''et al.'' |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671-4 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200 }}
*{{cite journal  | author=Tomomori-Sato C |title=A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5846–51 |year= 2004 |pmid= 14638676 |doi= 10.1074/jbc.M312523200 |name-list-format=vanc| author2=Sato S  | author3=Parmely TJ  | display-authors=3  | last4=Banks  | first4=CA  | last5=Sorokina  | first5=I  | last6=Florens  | first6=L  | last7=Zybailov  | first7=B  | last8=Washburn  | first8=MP  | last9=Brower  | first9=CS }}
*{{cite journal | author=Wallberg AE, Yamamura S, Malik S, ''et al.'' |title=Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. |journal=Mol. Cell |volume=12 |issue= 5 |pages= 1137-49 |year= 2004 |pmid= 14636573 |doi=  }}
*{{cite journal  | author=Tomomori-Sato C, Sato S, Parmely TJ, ''et al.'' |title=A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5846-51 |year= 2004 |pmid= 14638676 |doi= 10.1074/jbc.M312523200 }}
}}
}}
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Latest revision as of 00:07, 6 September 2018

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Wikidata
View/Edit Human

Mediator of RNA polymerase II transcription subunit 14 is an enzyme that in humans is encoded by the MED14 gene.[1][2][3]

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.[3]

Interactions

MED14 has been shown to interact with PPARGC1A,[4] Estrogen receptor alpha,[5] STAT2,[6] Cyclin-dependent kinase 8,[7][8] Glucocorticoid receptor[9] and Hepatocyte nuclear factor 4 alpha.[10][11]

References

  1. ↑ Ryu S, Zhou S, Ladurner AG, Tjian R (Feb 1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature. 397 (6718): 446–50. Bibcode:1999Natur.397..446R. doi:10.1038/17141. PMID 9989412.
  2. ↑ Yoshikawa H, Fujiyama A, Nakai K, Inazawa J, Matsubara K (Aug 1998). "Detection and isolation of a novel human gene located on Xp11.2-p11.4 that escapes X-inactivation using a two-dimensional DNA mapping method". Genomics. 49 (2): 237–46. doi:10.1006/geno.1998.5246. PMID 9598311.
  3. ↑ 3.0 3.1 "Entrez Gene: CRSP2 cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa".
  4. ↑ Wallberg, Annika E; Yamamura Soichiro; Malik Sohail; Spiegelman Bruce M; Roeder Robert G (Nov 2003). "Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha". Mol. Cell. 12 (5): 1137–49. doi:10.1016/S1097-2765(03)00391-5. ISSN 1097-2765. PMID 14636573.
  5. ↑ Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2642–7. Bibcode:2002PNAS...99.2642K. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769.
  6. ↑ Lau, Joe F; Nusinzon Inna; Burakov Darya; Freedman Leonard P; Horvath Curt M (Jan 2003). "Role of metazoan mediator proteins in interferon-responsive transcription". Mol. Cell. Biol. 23 (2): 620–8. doi:10.1128/MCB.23.2.620-628.2003. ISSN 0270-7306. PMC 151539. PMID 12509459.
  7. ↑ Wang, G; Cantin G T; Stevens J L; Berk A J (Jul 2001). "Characterization of mediator complexes from HeLa cell nuclear extract". Mol. Cell. Biol. 21 (14): 4604–13. doi:10.1128/MCB.21.14.4604-4613.2001. ISSN 0270-7306. PMC 87123. PMID 11416138.
  8. ↑ Ito, M; Yuan C X; Malik S; Gu W; Fondell J D; Yamamura S; Fu Z Y; Zhang X; Qin J; Roeder R G (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell. 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. ISSN 1097-2765. PMID 10198638.
  9. ↑ Hittelman, A B; Burakov D; Iñiguez-Lluhí J A; Freedman L P; Garabedian M J (Oct 1999). "Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins". EMBO J. 18 (19): 5380–8. doi:10.1093/emboj/18.19.5380. ISSN 0261-4189. PMC 1171607. PMID 10508170.
  10. ↑ Maeda, Yutaka; Rachez Christophe; Hawel Leo; Byus Craig V; Freedman Leonard P; Sladek Frances M (Jul 2002). "Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205". Mol. Endocrinol. 16 (7): 1502–10. doi:10.1210/mend.16.7.0883. ISSN 0888-8809. PMID 12089346.
  11. ↑ Malik, Sohail; Wallberg Annika E; Kang Yun Kyoung; Roeder Robert G (Aug 2002). "TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4". Mol. Cell. Biol. 22 (15): 5626–37. doi:10.1128/MCB.22.15.5626-5637.2002. ISSN 0270-7306. PMC 133960. PMID 12101254.

Further reading


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