Lung cancer classification: Difference between revisions
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====Squamous cell carcinoma==== | ====Squamous cell carcinoma==== | ||
* Papillary carcinoma | * Papillary carcinoma | ||
* Clear cell carcinoma | * [[Clear cell carcinoma of the lung|Clear cell carcinoma]] | ||
* Small cell carcinoma | * [[Small cell carcinoma]] | ||
* Basaloid carcinoma | * [[Basal cell carcinoma|Basaloid carcinoma]] | ||
====Small cell carcinoma==== | ====Small cell carcinoma==== | ||
| Line 43: | Line 43: | ||
====Adenocarcinoma==== | ====Adenocarcinoma==== | ||
* Adenocarcinoma, mixed subtype | * [[Adenocarcinoma of lung|Adenocarcinoma]], mixed subtype | ||
* Acinar adenocarcinoma | * [[Acinic cell carcinoma|Acinar]] adenocarcinoma | ||
* Papillary adenocarcinoma | * Papillary adenocarcinoma | ||
* Bronchioloalveolar carcinoma | * [[Bronchioloalveolar carcinoma]] | ||
:* Nonmucinous | :* Nonmucinous | ||
:* Mucinous | :* [[Mucinous carcinoma|Mucinous]] | ||
:* Mixed nonmucinous and mucinous or indeterminate | :* Mixed nonmucinous and mucinous or indeterminate | ||
* Solid adenocarcinoma with mucin production | * Solid adenocarcinoma with mucin production | ||
:* Fetal adenocarcinoma | :* Fetal adenocarcinoma | ||
:* Mucinous (“colloid”) carcinoma | :* Mucinous (“colloid”) carcinoma | ||
:* Mucinous cystadenocarcinoma | :* [[Mucinous cystadenocarcinoma]] | ||
:* Signet ring adenocarcinoma | :* [[Signet ring cell carcinoma|Signet ring adenocarcinoma]] | ||
:* Clear cell adenocarcinoma | :* [[Clear cell carcinoma of the lung|Clear cell]] adenocarcinoma | ||
====Large cell carcinoma==== | ====Large cell carcinoma==== | ||
* Large cell neuroendocrine carcinoma | * [[Large cell neuroendocrine carcinoma of the lung|Large cell neuroendocrine carcinoma]] | ||
:* Combined large cell neuroendocrine carcinoma | :* Combined large cell neuroendocrine carcinoma | ||
* Basaloid carcinoma | * Basaloid carcinoma | ||
* Lymphoepithelioma-like carcinoma | * [[Lymphoepithelioma-like carcinoma of the lung|Lymphoepithelioma-like carcinoma]] | ||
* Clear cell carcinoma | * Clear cell carcinoma | ||
* Large cell carcinoma with rhabdoid phenotype | * Large cell carcinoma with [[Malignant rhabdoid tumor|rhabdoid]] phenotype | ||
====Adenosquamous carcinoma==== | ====Adenosquamous carcinoma==== | ||
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* Giant cell carcinoma | * Giant cell carcinoma | ||
* Carcinosarcoma | * Carcinosarcoma | ||
* Pulmonary blastoma | * [[Pleuropulmonary blastoma|Pulmonary blastoma]] | ||
====Carcinoid tumor==== | ====Carcinoid tumor==== | ||
Revision as of 17:53, 8 February 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Kim-Son H. Nguyen, M.D., M.P.A., Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA; Cafer Zorkun, M.D., Ph.D. [2]; Rim Halaby, M.D. [3]
Overview
Primary lung cancers may be classified into two main categories: small cell lung cancer (~15%) and non small cell lung cancer (~85%). Non small cell lung cancer are a heterogenous group of lung cancers that are often grouped together because they share similar clinical features (e.g. prognosis and management). The 2004 WHO histological classification of tumors of the lung categorized lung tumors into malignant epithelial tumors, benign epithelial tumors, lymphoproliferative tumors, miscellaneous tumors, and metastatic tumors.
Classification
Primary lung cancers may be classified into two main categories:[1]
- Small cell lung cancer (~15%)
- Non small cell lung cancer (~85%).
| Lung Cancer | |||||||||||||||
Small cell lung cancer (~15%) | |||||||||||||||
Non small cell lung cancer (~85%)
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WHO Histological Classification of Tumors of the Lung
The World Health Organization (WHO) classifies tumors of the lungs as follows:[1]
Malignant Epithelial Tumors
Squamous cell carcinoma
- Papillary carcinoma
- Clear cell carcinoma
- Small cell carcinoma
- Basaloid carcinoma
Small cell carcinoma
- Combined small cell carcinoma
Adenocarcinoma
- Adenocarcinoma, mixed subtype
- Acinar adenocarcinoma
- Papillary adenocarcinoma
- Bronchioloalveolar carcinoma
- Nonmucinous
- Mucinous
- Mixed nonmucinous and mucinous or indeterminate
- Solid adenocarcinoma with mucin production
- Fetal adenocarcinoma
- Mucinous (“colloid”) carcinoma
- Mucinous cystadenocarcinoma
- Signet ring adenocarcinoma
- Clear cell adenocarcinoma
Large cell carcinoma
- Combined large cell neuroendocrine carcinoma
- Basaloid carcinoma
- Lymphoepithelioma-like carcinoma
- Clear cell carcinoma
- Large cell carcinoma with rhabdoid phenotype
Adenosquamous carcinoma
Sarcomatoid carcinoma
- Pleomorphic carcinoma
- Spindle cell carcinoma
- Giant cell carcinoma
- Carcinosarcoma
- Pulmonary blastoma
Carcinoid tumor
- Typical carcinoid
- Atypical carcinoid
Other tumors that may affect the lungs
Salivary gland tumors
- Mucoepidermoid carcinoma
- Adenoid cystic carcinoma
- Epithelial-myoepithelial carcinoma
- Preinvasive lesions
- Squamous carcinoma in situ
- Atypical adenomatous hyperplasia
- Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia
Mesenchymal tumors
- Epithelioid haemangioendothelioma
- Angiosarcoma
- Pleuropulmonary blastoma
- Chondroma
- Congenial peribronchial myofibroblastic tumor
- Diffuse pulmonary lymphangiomatosis
- Inflammatory myofibroblastic tumor
- Lymphangioleiomyomatosis
- Synovial sarcoma
- Pulmonary artery sarcoma
- Pulmonary vein sarcoma
Benign Epithelial Tumors
- Papillomas
- Squamous cell papilloma (either exophytic or inverted)
- Glandular papilloma
- Mixed squamous cell and glandular papilloma
- Adenomas
- Alveolar adenoma
- Papillary adenoma
- Adenomas of the salivary gland type
- Mucous gland adenoma
- Pleomorphic adenoma
- Others
- Mucinous cystadenoma
Lymphoproliferative Tumors
- Marginal zone B-cell lymphoma of the MALT type
- Diffuse large B-cell lymphoma
- Lymphomatoid granulomatosis
- Langerhans cell histiocytosis
Miscellaneous Tumors
- Hamartoma
- Sclerosing hemangioma
- Clear cell tumor
- Germ cell tumors
- Teratoma, mature
- Immature
- Other germ cell tumors
- Intrapulmonary thymoma
- Melanoma
References
- ↑ 1.0 1.1 Travis, William (2004). Pathology and genetics of tumours of the lung, pleura, thymus, and heart. Lyon: IARC Press. ISBN 9283224183.
- ↑ Raz, DJ (Mar 2006). "Bronchioloalveolar carcinoma: a review". Clinical Lung Cancer. Cancer Information Group. 7 (5): 313–322. PMID 16640802. Unknown parameter
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