Leukocytosis

Jump to navigation Jump to search

Template:DiseaseDisorder infobox

WikiDoc Resources for Leukocytosis

Articles

Most recent articles on Leukocytosis

Most cited articles on Leukocytosis

Review articles on Leukocytosis

Articles on Leukocytosis in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Leukocytosis

Images of Leukocytosis

Photos of Leukocytosis

Podcasts & MP3s on Leukocytosis

Videos on Leukocytosis

Evidence Based Medicine

Cochrane Collaboration on Leukocytosis

Bandolier on Leukocytosis

TRIP on Leukocytosis

Clinical Trials

Ongoing Trials on Leukocytosis at Clinical Trials.gov

Trial results on Leukocytosis

Clinical Trials on Leukocytosis at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Leukocytosis

NICE Guidance on Leukocytosis

NHS PRODIGY Guidance

FDA on Leukocytosis

CDC on Leukocytosis

Books

Books on Leukocytosis

News

Leukocytosis in the news

Be alerted to news on Leukocytosis

News trends on Leukocytosis

Commentary

Blogs on Leukocytosis

Definitions

Definitions of Leukocytosis

Patient Resources / Community

Patient resources on Leukocytosis

Discussion groups on Leukocytosis

Patient Handouts on Leukocytosis

Directions to Hospitals Treating Leukocytosis

Risk calculators and risk factors for Leukocytosis

Healthcare Provider Resources

Symptoms of Leukocytosis

Causes & Risk Factors for Leukocytosis

Diagnostic studies for Leukocytosis

Treatment of Leukocytosis

Continuing Medical Education (CME)

CME Programs on Leukocytosis

International

Leukocytosis en Espanol

Leukocytosis en Francais

Business

Leukocytosis in the Marketplace

Patents on Leukocytosis

Experimental / Informatics

List of terms related to Leukocytosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Lakshmi Gopalakrishnan, M.B.B.S. [2]

Synonyms and keywords: Granulocytosis, neutrophilia

Overview

Leukocytosis is an elevation of the white blood cell count (the leukocyte count) above the normal range. The normal adult human leukocyte count in peripheral blood is 4.4-10.8 x 109/L. A white blood count of 11.0 x 109/L or more suggests leukocytosis. Often, the word refers to an increased neutrophil granulocyte count, as neutrophils are the main granulocytes. An increase in eosinophil granulocyte is known as eosinophilia. Granulocytosis can be a feature of a number of disease processes including infection, especially bacteria; malignancy, most notably leukemia (it is the main feature of chronic myelogenous leukemia, CML) and autoimmune disease. Although it may be a sign of illness, leukocytosis in-and-of itself is not a disorder, nor is it a disease. It is simply a laboratory finding.

Epidemiology and Demographics

Leukocytosis is very common in acutely ill patients. It occurs in response to a wide variety of conditions, including viral, bacterial, fungal, or parasitic infection, cancer, hemorrhage, and exposure to certain medications or chemicals including steroids. Leukocytosis can also be the first indication of neoplastic growth of leukocytes.

Pathophysiology

The mechanism that causes leukocytosis can be of several forms: an increased release of leukocytes from bone marrow storage pools, decreased margination of leukocytes onto vessel walls, decreased extravasation of leukocytes from the vessels into tissues, or an increase in number of precursor cells in the marrow.

Classification Scheme

Leukocytosis can be subcategorized by the type of white blood cell that is increased in number.

Granulocytosis / Neutrophilia

Granulocytosis or neutrophilia is a subcategory of leukocytosis in which neutrophil count is elevated.

For complete list of conditions that cause neutrophilia, click here

Eosinophilia

Eosinophilia is a subcategory of leukocytosis in which eosinophil count is elevated.

For complete list of conditions that cause eosinophilia, click here

Monocytosis

Monocytosis is a subcategory of leukocytosis in which monocyte count is elevated.

For complete list of conditions that cause monocytosis, click here

Basophilia

Basophilia is a subcategory of leukocytosis in which basophilia count is elevated.

For complete list of conditions that cause basophilia, click here

Lymphocytosis

Lymphocytosis is a subcategory of leukocytosis in which lymphocyte count is elevated.

For complete list of conditions that cause neutrophilia, click here

Leukemoid Reaction

A leukocyte count of above 25 to 30 x 109/L is termed as leukemoid reaction. This occurs as a reaction of healthy bone marrow to extreme stress, trauma, or infection.

Leukemoid reaction is different from leukemia and from leukoerythroblastosis, in which immature blood cells are present in peripheral blood.

Differential Diagnosis of Causes of Leukocytosis (specifically)

By Organ System

Cardiovascular [No underlying causes
Chemical / poisoning No underlying causes
Dermatologic No underlying causes
Drug Side Effect Plerixafor
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic Colonic diverticulitis
Genetic Interleukin 1 receptor antagonist deficiency
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal / Ortho No underlying causes
Neurologic No underlying causes
Nutritional / Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic Hepatosplenic T-cell lymphoma
Opthalmologic No underlying causes
Overdose / Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous Neuroleptic malignant syndrome

In alphabetical order[1] [2]

Related Chapters

References

  1. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X

Template:Hematology



Template:WikiDoc Sources