Large cell carcinoma of the lung classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Overview

According to the World Health Organization (WHO), large cell carcinoma of the lung can be classified into 6 sub-types based on histo-pathology which include giant-cell carcinoma of the lung, basaloid large cell carcinoma of the lung, clear cell carcinoma of the lung, lymphoepithelioma-like carcinoma of the lung, large-cell lung carcinoma with rhabdoid phenotype, and large cell neuroendocrine carcinoma of the lung.

Classification

The table below summarizes the WHO histological classification system for large cell carcinoma of the lung.[1][2]

WHO histological classification system
Adapted from WHO/IARC (2006) [3]
Main type Subtypes
Large cell carcinoma of the lung
  • Giant-cell carcinoma of the lung
  • Basaloid large cell carcinoma of the lung
  • Clear cell carcinoma of the lung
  • Lymphoepithelioma-like carcinoma of the lung
  • Large-cell lung carcinoma with rhabdoid phenotype
  • Large cell neuroendocrine carcinoma of the lung

References

  1. Travis, William (2004). Pathology and genetics of tumours of the lung, pleura, thymus, and heart. Lyon: IARC Press. ISBN 9283224183.
  2. Raz DJ, He B, Rosell R, Jablons DM (2006). "Bronchioloalveolar carcinoma: a review". Clin Lung Cancer. 7 (5): 313–22. doi:10.3816/CLC.2006.n.012. PMID 16640802.
  3. Tumors of the Lung. IARC/WHO https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/bb10-chap1.pdf Accessed on February 22, 2016