Large cell carcinoma of the lung epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Overview

Large cell carcinoma of the lung accounts for 5% and 10% of all lung cancers. Other subtypes of large cell carcinoma of the lung, such as large cell neureoendocrine carcinoma and lymphoepithelioma-like carcinoma are rare, and represent only 1-3% of lung cancers. Large cell carcinoma of the lung accounts for less than 2% of all cancer deaths. The incidence of large cell carcinoma of the lung increases with age; the median age at diagnosis is approximately 60 years.[1] Large cell carcinoma of the lung is most frequently diagnosed among patients between 55 to 65 years old. Males are more commonly affected with large cell carcinoma of the lung than females. Asian race has a higher incidence of lymphoepithelioma-like large lung cell carcinoma compared to the white race.[2]

Epidemiology and Demographics

Prevalence

  • Large cell carcinoma of the lung accounts for 5% and 10% of all lung cancers
  • Other subtypes of large cell carcinoma of the lung, such as large cell neureoendocrine carcinoma and lymphoepithelioma-like carcinoma are rare, and represent only 1-3% of lung cancers
  • Large cell carcinoma of the lung accounts for less than 2% of all cancer deaths

Incidence

  • The incidence rate of large cell carcinoma of the lung has been decreasing over the past 10 years[1]
  • Shown below is a pie chart showing incidence of large-cell lung cancer (shown in green at upper left) as compared to other lung cancer types, with fractions of smokers versus non-smokers shown for each type
Pie chart showing incidence of large-cell lung cancer (shown in green at upper left) as compared to other lung cancer types
Adapted from Wikipedia

Age

  • The incidence of large cell carcinoma of the lung increases with age; the median age at diagnosis is approximately 60 years[1]
  • Large cell carcinoma of the lung is most frequently diagnosed among patients between 55 to 65 years old

Gender

  • Males are more commonly affected with large cell carcinoma of the lung than females[2]

Race

  • Asian race has a higher incidence of lymphoepithelioma-like large cell carcinoma of the lung compared to the white race



References

  1. 1.0 1.1 1.2 Meza R, Meernik C, Jeon J, Cote ML (2015). "Lung cancer incidence trends by gender, race and histology in the United States, 1973-2010". PLoS ONE. 10 (3): e0121323. doi:10.1371/journal.pone.0121323. PMC 4379166. PMID 25822850.
  2. 2.0 2.1 Downey RS, Sewell CW, Mansour KA (1989). "Large cell carcinoma of the lung: a highly aggressive tumor with dismal prognosis". Ann. Thorac. Surg. 47 (6): 806–8. PMID 2547348.


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