Kidney stone natural history, complications and prognosis: Difference between revisions

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{{Kidney stone}}
{{Kidney stone}}


{{CMG}}; {{AE}}  
{{CMG}}; {{AE}}{{ADS}}  


==Overview==
==Overview==
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
If left untreated, <30% of patients with nephrolithiasis may progress to develop renal colicky pain due to increase in rate of growth.Most of the stones pass spontaneously. about 10-20% of symptom-causing stones fail to pass. Lower poles stones were significantly less likely to cause symptoms or pass spontaneously. They can progress to hydronephrosis especially when combined or superimposed by u[[Urinary tract infection|rinary tract infection]]. Common complications of nephrolithiasis include [[hydronephrosis]], [[chronic renal failure]], [[hypertension]], [[cardiovascular disease]], and increased risk of fracture. Prognosis is generally excellent. Approximately 80-85% resolve spontaneously. Recurrence rates for calcium stones after the initial event is 40–50% at the end of 5 years and 50–60% at the end of 10 years.


OR
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
OR
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
==Natural History, Complications, and Prognosis==
==Natural History, Complications, and Prognosis==


===Natural History===
===Natural History===
*The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.
*If left untreated, <30% of patients with nephrolithiasis may progress to develop renal colicky pain due to increase in rate of growth.<ref name="pmid25463995">{{cite journal |vauthors=Dropkin BM, Moses RA, Sharma D, Pais VM |title=The natural history of nonobstructing asymptomatic renal stones managed with active surveillance |journal=J. Urol. |volume=193 |issue=4 |pages=1265–9 |date=April 2015 |pmid=25463995 |doi=10.1016/j.juro.2014.11.056 |url=}}</ref>  
*The symptoms of (disease name) typically develop ___ years after exposure to ___.
*If left untreated, <30% of patients with nephrolithiasis may progress to develop renal colicky pain due to increase in rate of growth.<ref name="pmid25463995">{{cite journal |vauthors=Dropkin BM, Moses RA, Sharma D, Pais VM |title=The natural history of nonobstructing asymptomatic renal stones managed with active surveillance |journal=J. Urol. |volume=193 |issue=4 |pages=1265–9 |date=April 2015 |pmid=25463995 |doi=10.1016/j.juro.2014.11.056 |url=}}</ref>
*Most of the stones pass spontaneously. about 10-20% of symptom causing stones fail to pass.<ref name="pmid18486720">{{cite journal |vauthors=Worcester EM, Coe FL |title=Nephrolithiasis |journal=Prim. Care |volume=35 |issue=2 |pages=369–91, vii |date=June 2008 |pmid=18486720 |pmc=2518455 |doi=10.1016/j.pop.2008.01.005 |url=}}</ref>
*Most of the stones pass spontaneously. about 10-20% of symptom causing stones fail to pass.<ref name="pmid18486720">{{cite journal |vauthors=Worcester EM, Coe FL |title=Nephrolithiasis |journal=Prim. Care |volume=35 |issue=2 |pages=369–91, vii |date=June 2008 |pmid=18486720 |pmc=2518455 |doi=10.1016/j.pop.2008.01.005 |url=}}</ref>
*Less than 30% caused renal colic, less than 20% were operated on for pain and 7% spontaneously passed. Lower poles stones were significantly less likely to cause symptoms or pass spontaneously. Despite 3 stones causing silent hydronephrosissuggestive of obstruction, regular followup imaging facilitated interventions t
*Lower poles stones were significantly less likely to cause symptoms or pass spontaneously.
*They can progress to hydronephrosis especially when combined or superimposed by u[[Urinary tract infection|rinary tract infection]].


===Complications===
===Complications===
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**[[Hypertension]]<ref name="pmid9820450">{{cite journal |vauthors=Madore F, Stampfer MJ, Willett WC, Speizer FE, Curhan GC |title=Nephrolithiasis and risk of hypertension in women |journal=Am. J. Kidney Dis. |volume=32 |issue=5 |pages=802–7 |date=November 1998 |pmid=9820450 |doi= |url=}}</ref>
**[[Hypertension]]<ref name="pmid9820450">{{cite journal |vauthors=Madore F, Stampfer MJ, Willett WC, Speizer FE, Curhan GC |title=Nephrolithiasis and risk of hypertension in women |journal=Am. J. Kidney Dis. |volume=32 |issue=5 |pages=802–7 |date=November 1998 |pmid=9820450 |doi= |url=}}</ref>
**[[Cardiovascular Disease]]<ref name="pmid23917291">{{cite journal |vauthors=Ferraro PM, Taylor EN, Eisner BH, Gambaro G, Rimm EB, Mukamal KJ, Curhan GC |title=History of kidney stones and the risk of coronary heart disease |journal=JAMA |volume=310 |issue=4 |pages=408–15 |date=July 2013 |pmid=23917291 |pmc=4019927 |doi=10.1001/jama.2013.8780 |url=}}</ref>
**[[Cardiovascular Disease]]<ref name="pmid23917291">{{cite journal |vauthors=Ferraro PM, Taylor EN, Eisner BH, Gambaro G, Rimm EB, Mukamal KJ, Curhan GC |title=History of kidney stones and the risk of coronary heart disease |journal=JAMA |volume=310 |issue=4 |pages=408–15 |date=July 2013 |pmid=23917291 |pmc=4019927 |doi=10.1001/jama.2013.8780 |url=}}</ref>
**Increased risk of fracture<ref name="pmid25341724">{{cite journal |vauthors=Denburg MR, Leonard MB, Haynes K, Tuchman S, Tasian G, Shults J, Copelovitch L |title=Risk of fracture in urolithiasis: a population-based cohort study using the health improvement network |journal=Clin J Am Soc Nephrol |volume=9 |issue=12 |pages=2133–40 |date=December 2014 |pmid=25341724 |pmc=4255404 |doi=10.2215/CJN.04340514 |url=}}</ref>


===Prognosis===
===Prognosis===
*Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
*Prognosis is generally excellent.
*Depending on the extent of the [tumor/disease progression/etc.] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
*Approximately 80-85% resolve spontaneously
*The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
*Recurrence rates for calcium stones after the initial event is 40–50% at the end of 5 years and 50–60% at the end of 10 years.<ref name="pmid184867202">{{cite journal |vauthors=Worcester EM, Coe FL |title=Nephrolithiasis |journal=Prim. Care |volume=35 |issue=2 |pages=369–91, vii |date=June 2008 |pmid=18486720 |pmc=2518455 |doi=10.1016/j.pop.2008.01.005 |url=}}</ref>
*[Subtype of disease/malignancy] is associated with the most favorable prognosis.
*The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.


==References==
==References==

Latest revision as of 06:05, 22 June 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]

Overview

If left untreated, <30% of patients with nephrolithiasis may progress to develop renal colicky pain due to increase in rate of growth.Most of the stones pass spontaneously. about 10-20% of symptom-causing stones fail to pass. Lower poles stones were significantly less likely to cause symptoms or pass spontaneously. They can progress to hydronephrosis especially when combined or superimposed by urinary tract infection. Common complications of nephrolithiasis include hydronephrosis, chronic renal failure, hypertension, cardiovascular disease, and increased risk of fracture. Prognosis is generally excellent. Approximately 80-85% resolve spontaneously. Recurrence rates for calcium stones after the initial event is 40–50% at the end of 5 years and 50–60% at the end of 10 years.

Natural History, Complications, and Prognosis

Natural History

  • If left untreated, <30% of patients with nephrolithiasis may progress to develop renal colicky pain due to increase in rate of growth.[1]
  • Most of the stones pass spontaneously. about 10-20% of symptom causing stones fail to pass.[2]
  • Lower poles stones were significantly less likely to cause symptoms or pass spontaneously.
  • They can progress to hydronephrosis especially when combined or superimposed by urinary tract infection.

Complications

Prognosis

  • Prognosis is generally excellent.
  • Approximately 80-85% resolve spontaneously
  • Recurrence rates for calcium stones after the initial event is 40–50% at the end of 5 years and 50–60% at the end of 10 years.[6]

References

  1. Dropkin BM, Moses RA, Sharma D, Pais VM (April 2015). "The natural history of nonobstructing asymptomatic renal stones managed with active surveillance". J. Urol. 193 (4): 1265–9. doi:10.1016/j.juro.2014.11.056. PMID 25463995.
  2. Worcester EM, Coe FL (June 2008). "Nephrolithiasis". Prim. Care. 35 (2): 369–91, vii. doi:10.1016/j.pop.2008.01.005. PMC 2518455. PMID 18486720.
  3. Madore F, Stampfer MJ, Willett WC, Speizer FE, Curhan GC (November 1998). "Nephrolithiasis and risk of hypertension in women". Am. J. Kidney Dis. 32 (5): 802–7. PMID 9820450.
  4. Ferraro PM, Taylor EN, Eisner BH, Gambaro G, Rimm EB, Mukamal KJ, Curhan GC (July 2013). "History of kidney stones and the risk of coronary heart disease". JAMA. 310 (4): 408–15. doi:10.1001/jama.2013.8780. PMC 4019927. PMID 23917291.
  5. Denburg MR, Leonard MB, Haynes K, Tuchman S, Tasian G, Shults J, Copelovitch L (December 2014). "Risk of fracture in urolithiasis: a population-based cohort study using the health improvement network". Clin J Am Soc Nephrol. 9 (12): 2133–40. doi:10.2215/CJN.04340514. PMC 4255404. PMID 25341724.
  6. Worcester EM, Coe FL (June 2008). "Nephrolithiasis". Prim. Care. 35 (2): 369–91, vii. doi:10.1016/j.pop.2008.01.005. PMC 2518455. PMID 18486720.

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